Dental Amalgam-Civa Toksisitesi

Öz

Dental amalgam diş hekimliğinde sıklıkla kullanılan bir restorasyon materyalidir. Son yıllarda içeriğindeki civa sebebiyle sıklıkla çeşitli nörolojik hastalıklar ile ilişkilendirilmektedir. Bu tartışmanın amacı konuyla ilgisi olabileceği düşünülen hastalıkların değerlendirilmesidir.

Anahtar Kelimeler

• Amalgam,Civa,Parkinson hastalığı

Dental Amalgam-Mercury Toxicity

Abstract

Dental amalgam is commonly used as a restorative material in dentistry. In recent years, it has been often associated with various neurological diseases due to the content of mercury. In this paper, we aimed to discuss diseases which may be related to the toxic effects of amalgam.

Keywords

• Amalgam,Mercury,Parkinson’s Disease

Kaynakça

1. Shenoy A. Is it the end of the road for dental amalgam? A critical review. J Conserv Dent 2008;11(3):99–107.
2. DeRouen TA, Martin MD, Leroux BG et al. Neurobehavioral effects of dental amalgam in children. A randomized clinical trial. JAMA 2006;295(15):1784-92.
3. Bates MN, Fawcett J, Garrett N, Cutress T, Kjellstrom T. Health effects of dental amalgam exposure: a retrospective cohort study. Int J Epidemiol 2004;33(4):894–902.
4. Stejskal VDM, Danersund A,Lindvall A, Hudecek R, Nordman V, Yaqob A, Mayer W, Bieger W, Lindh U. Metal-specific lymphocytes: biomarkers of sensitivity in man. Neuroendocrinology Letters 1999;20(5):89-98.
5. Huggins HA, Levy TE. Cerebrospinal fluid protein changes in Multiple Sclerosis after dental amalgam removal. Altern Med Rev 1998;3(4):295-300.
6. Svare CW, Peterson LC, Reinhardt JW et al. The effect of dental amalgams on mercury levels in expired air. J Dent Res 1981;60(9):68-71.
7. Clarkson TW, Magos, L, Myers GJ. The toxicology of mercury-Current exposures and clinical manifestations. NEJM 2003;349(18):31-7.
8. Satoh H. Occupational and environmental toxicology of mercury and its compounds. Ind Health 2000;38(2):53-64.

9. Mortazavi Gh, Haghani M, Rastegarian N, Zarei S, Mortazavi SMJ. Increased release of mercury from dental amalgam fillings due to maternal exposure to electromagnetic fields as a possible mechanism for the high rates of autism in the offspring: ıntroducing a hypothesis. J Biomed Phys Eng 2016;6(1):41-6.
10. Pierzchala B, Labuz-Roszak B, Pierzchala E, Tyrpien K. Oral health in multiple sclerosis patients. Wiad Lek 2014;67(2):93-6.
11. Bangsi D, Ghadirian P, Ducic S, Morisset R, Ciccocioppo S, McMullen E, Krewski D. Dental amalgam and multiple sclerosis: a case-control study in Montreal, Canada. Int J Epidemiol 1998;27(4):67-71.
12. Ingalls TH. Epidemiology, etiology, and prevention of multiple sclerosis. Hypothesis and fact. Am J Forensic Med Pathol 1983;4(1):55-61.
13. Aminzadeh KK, Etminan M. Dental amalgam and multiple sclerosis: a systematic review and meta-analysis. J Public Health Dent 2007;67(1):64-6.
14. Saxe SR, Wekstein MW, Kryscio RJ, Henry RG, Cornett CR, Snowdon DA, Grant FT, Schmitt FA, Donegan SJ, Wekstein DR, Ehmann WD, Markesbery WR. Alzheimer's disease, dental amalgam and mercury. J Am Dent Assoc 1999;130(2):1-9.
15. Hock C, Drasch G, Golombowski S, Müller-Spahn F, Willershausen-Zönnchen B, Schwarz P, Hock U, Growdon JH, Nitsch RM. Increased blood mercury levels in patients with Alzheimer’s disease. J Neural Transm 1998;105(1):59-68.
16. Sun Y, Nfor OD, Huang, Lia Y. Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan. Alzheimer's Research & Therapy 2015;7(1):65.
17. Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Front Cell Neurosci 2015;9:124.
18. Uversky VN, Li J, Fink AL. Metal-triggered structural transformations, aggregation, and fibrillation of human-synuclein. J Biol Chem 2001;276(47):84-96.
19. Ohlson CG, Hogstedt C. Parkinson’s disease and occupational exposure to organic solvents, agricultural chemicals and mercury-a case referent study. Scand J Work Health 1981;7(4):2-6.
20. Fabrizio E, Vanacore N, Valente M, Rubino A, Meco G. High prevalence of extrapyramidal signs and symptoms in a group of Italian dental technicians. BMC Neurology 2007;7:24.
21. Dantzig PI. Parkinson's disease, macular degeneration and cutaneous signs of mercury toxicity. J Occup Environ Med 2006;48(7):656.
22. Björkblom B, Adilbayeva A, Maple-Grødem J, Piston D, Ökvist M, Xu XM, Cato Brede, Larsen JP, Moller SG. Parkinson disease protein dj-1 binds metals and protects against metal-induced cytotoxicity. J Biol Chem 2013;288(31):9-20.
23. Ngim CH, Devathasan G. Epidemiologic study on the asso- ciation between body burden mercury level and idiopathic Parkinson’s disease. Neuroepidemiology 1989;8(3):128-41.
24. Ohlson CG, Hogstedt C. Parkinson's disease and occupational exposure to organic solvents, agricultural chemicals and mercury - A case-referent study. Scand J Work Environ Health 1981;7(4):2-6.
25. Axéll T. Hypersensitivity of the oral mucosa: clinics and pathology. Acta Odontol Scand 2001;59(5):5-9.
26. Sye M, Chopra R, Sachdev V. Allergic reactions to dental materials- A systematic review. J Clin Diagn Res 2015;9(10):4-9.
27. Fuks AB. The use of amalgam in pediatric dentistry. Pediatr Dent 2002;24(5):48-55.
28. Eyeson J, House I, Yang YH, K, Warnakulasuriya KAAS. Relationship between mercury levels in blood and urine and complaints of chronic mercury toxicity from amalgam restorations. BDJ 2010;208(4):2-3.
29. Osborne JW, Albino JE. Psychological and medical effects of mercury intake from dental amalgam. A status report for the American Journal of Dentistry. Am J Dent 1999;12(3):1-6.