Prognostic Importance of Albumin Globulin Ratio in Small Cell Lung Cancer

Abstract

Objectives: Inflammation has an important role for tumor development and also associated with poor prognosis in various cancer types. Albumin and globulin are two biomarkers that can reflect inflammation. However, albumin level can be affected in many conditions. Thus, albumin-globulin ratio (AGR) was found as a more successful biomarker for reflection of inflammation compared with albumin alone. In this article, we aim that investigated to the prognostic effect of AGR in small cell lung cancer (SCLC). Materials and Methods: We analyzed the patients who were diagnosed with SCLC between 2014-2018, retrospectively. AGR was calculated by divided albumin to globulin level at the diagnosis. Cut off level for AGR was accepted as 1.2. Results: totally, 81 patients were enrolled to study. Percent of patients with AGR < 1.2 were 40.30% and AGR ≥ 1.2 were 50.30%. Patients characteristics were similar between the groups. We found that negative correlation between AGR and neutrophil-lymphocyte ratio and platelet-lymphocyte ratio, significantly. Progression free survival and overall survival were longer in AGR ≥ 1.2 group. Conclusion: AGR is a cheap and easy biomarker. Thus, it can be used for prognostic biomarker for SCLC.

Keywords

• Albumin,globulin,inflammation,survival

Albümin Globulin Oranının Küçük Hücreli Akciğer Kanserinde Prognostik Önemi

Öz

Giriş: İnflamasyon kanser gelişimini kolaylaştırmanın yanı sıra birçok kanser tipinde kötü prognozla da ilişkilidir. Albümin ve globülin inflamasyonu yansıtan belirteçlerden ikisidir. Albüminin özellikle inflamasyon dışı birçok nedenden etkilenebileceği için albümin globülin oranının inflamasyonu yansıtmada daha başarılı olacağı gösterilmiştir. Biz bu çalışmada albümin globülin oranın (AGO) küçük hücreli akciğer kanserinde (KHAK) prognostik öneminin belirlenmesi ve diğer inflamatuar parametrelerle ilişkisinin saptanmasını amaçladık. Materyal ve Metot: Retrospektif olarak 2014-2018 yılları arasından tanı almış KHAK hastaları çalışmaya dâhil edildi. Tanı anındaki albümin globüline bölünerek AGO bulundu. Medyan değer olan 1,2 AGO için eşik değer olarak kabul edildi. Bulgular: Toplam 81 hasta çalışmaya dâhil edildi. Hastaların %40,30’ü AGO < 1,2 olarak saptanırken, % 59,30’ünün ise AGO ≥ 1,2 olarak bulundu. Her iki grup hasta özellikleri açısından benzerdi. AGO ile nötrofil lenfosit oranı ve platelet lenfosit oranı arasında istatistiksel anlamlı ters korelasyon saptandı. AGO ≥ 1,2 olan grupta hem progresyonsuz sağkalım hem de genel sağkalım istatistiksel olarak daha uzundu. Sonuç: AGO hem kolay uygulanabilir hem de ucuz bir belirteç olması nedeniyle KHAK’de prognostik belirteç olarak kullanılabilir.

Anahtar Kelimeler

• Albümin,globulin,inflamasyon,sağ kalım

Kaynakça

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