AN ALTERNATIVE ORGANISM IN TOXICOLOGICAL RESEARCHES: Caenorhabditis elegans (C. elegans)

Öz

In recent years, toxic and potentially toxic substances have increased. These toxic substances affect the human health and environment in a negative way. It has been used many model organisms to show the negative effects. Caenorhabditis elegans (C. elegans) is one of the most important model organisms used for the toxicity studies. This organism has lots of intended purposes. When compared to the other organisms, it has some advantages and disadvantages on the use of toxicology studies. One of the most important advantages is that thanks to the automatic high-scale scans, it can be performed to scan for toxicity of hundreds or even thousands of substances at the same time. In this compilation, informations have been provided about C. elegans and its use in toxicity studies.

 

Anahtar Kelimeler

• Caenorhabditis elegans,model organism,toxicology,toxicity

TOKSİKOLOJİK ARAŞTIRMALARDA ALTERNATİF BİR ORGANİZMA: Caenorhabditis elegans (C. elegans)

Öz

Son yıllarda toksik ve toksik olma potansiyeli olan maddeler artış göstermektedir. Bu toksik maddeler çevre ve halk sağlığını olumsuz etkilemektedir. Bu olumsuz etkileri göstermek amacı ile birçok model organizma kullanılmaktadır. Caenorhabditis elegans (C. elegans) toksisite çalışmaları için kullanılan önemli model organizmalardan biridir. Bu organizmanın birçok kullanım amacı mevcuttur. Diğer model organizmalar ile karşılaştırıldığında toksikoloji çalışmalarında kullanılmasının bazı avantajları ve dezavantajları vardır. En önemli avantajlarından birisi de otomatik yüksek ölçekli taramaların yapılabilmesi sayesinde aynı anda yüzlerce hatta binlerce maddenin toksisite taramasının yapılabilmesidir. Bu derlemede C. elegans hakkında ve toksisite araştırmalarındaki kullanımı hakkında bilgiler verilmiştir.

Anahtar Kelimeler

• Caenorhabditis elegans,model organizma,toksikoloji

Kaynakça

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