AN ALTERNATIVE ORGANISM IN TOXICOLOGICAL RESEARCHES: Caenorhabditis elegans (C. elegans)

Yıl 2018, Cilt: 2 Sayı: 2, 99 - 106, 02.05.2018

Nazmi Savaş , Serdal Öğüt , Abdullah Olgun

Öz

In
recent years, toxic and potentially toxic substances have increased. These
toxic substances affect the human health and environment in a negative way. It
has been used many model organisms to show the negative effects. Caenorhabditis elegans (C. elegans) is
one of the most important model organisms used for the toxicity studies. This
organism has lots of intended purposes. When compared to the other organisms,
it has some advantages and disadvantages on the use of toxicology studies. One
of the most important advantages is that thanks to the automatic high-scale
scans, it can be performed to scan for toxicity of hundreds or even thousands
of substances at the same time. In this compilation, informations have been
provided about C. elegans and its use
in toxicity studies.

 

Anahtar Kelimeler

Caenorhabditis elegans, model organism, toxicology, toxicity

TOKSİKOLOJİK ARAŞTIRMALARDA ALTERNATİF BİR ORGANİZMA: Caenorhabditis elegans (C. elegans)

Öz

Son
yıllarda toksik ve toksik olma potansiyeli olan maddeler artış göstermektedir. Bu
toksik maddeler çevre ve halk sağlığını olumsuz etkilemektedir. Bu olumsuz
etkileri göstermek amacı ile birçok model organizma kullanılmaktadır. Caenorhabditis elegans (C. elegans) toksisite çalışmaları için
kullanılan önemli model organizmalardan biridir. Bu organizmanın birçok
kullanım amacı mevcuttur. Diğer model organizmalar ile karşılaştırıldığında
toksikoloji çalışmalarında kullanılmasının bazı avantajları ve dezavantajları
vardır. En önemli avantajlarından birisi de otomatik yüksek ölçekli taramaların
yapılabilmesi sayesinde aynı anda yüzlerce hatta binlerce maddenin toksisite
taramasının yapılabilmesidir. Bu derlemede C.
elegans hakkında ve toksisite araştırmalarındaki kullanımı hakkında
bilgiler verilmiştir.

Anahtar Kelimeler

Caenorhabditis elegans, model organizma, toksikoloji

Kaynakça

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