An Analysis of the Pharmacological Components of Herbal Teas Used for Galactagogue Effects by Gas Chromatography/Mass Spectrometry.

Yıl 2019, , 101 - 114, 13.06.2019

Kemal Gökhan Ulusoy , Fidan Pesen Özdoğan Seyfullah Oktay Arslan , Enis Macit Saliha Ayşenur Çam Fatma Uysal Muhammed Fatih Doğan

https://doi.org/10.21673/anadoluklin.494566

Öz

Aims: The
present study was designed to detect the phytochemical components of herbs and
herbal teas that are used to improve maternal milk production by gas
chromatography/mass spectrometry (GC/MS).

Methods: The
methanolic extracts were extracted by maceration method using rotary
evaporator. The essential oils of herbs were obtained by Clevenger method.

Results: The
GC/MS analysis of the essential oils or the methanol extracts of the mix of herbal
teas or herbs including Foeniculum
vulgare, Pimpinella anisum, Trigonella foenum graceum, Urtica dioica, Nigella sativa were listed as several compounds in this article.
Furthermore, the possible pharmacological effects of these components have been
discussed according to the literature.

Conclusions: The
findings of this study will guide researchers about the pharmacological active
ingredients of these herbs and herbal teas that may be used in the future for
milk enhancing or other medical purposes.

Anahtar Kelimeler

Milk-increasing herbal teas, Foeniculum vulgare, Pimpenella anisum, Trigonella foenum graceum, Urtica diotica, Nigella Sativa

Galaktagog Etki İçin Kullanılan Bitkisel Çayların Farmakolojik Bileşenlerinin Gaz Kromatografisi/ Kütle Spektrometrisi ile Analizi

Öz

Amaç:
Bu çalışmada, anne süt üretimini arttırmak için kullanılan bitki ve bitkisel
çayların bileşenlerinin gaz kromatografisi/kütle spektrometresi (GC/MS) ile
saptanması amaçlanmıştır.

Gereç ve Yöntemler:
Metanolikekstraksiyonlar, maserasyon metodu ve rotary buharlaştırıcı
kullanılarak hazırlanmıştır. Uçucu yağların elde edilmesinde ise Clavenger
yöntemi kullanılmıştır.

Bulgular:
Foeniculum vulgare, Pimpenella anisum,
Trigonella foenum graceum, Urtica dioica, Nigella Sativa tıbbi bitkilerinin
ve bunların karışım çaylarının uçucu yağları ve methanol ekstraksiyonlarının
GC/MS analizleri yüksek hassasiyetle gerçekleştirilmiştir. Analizlerde tespit
edilen kimyasal bileşenler ayrıntılı olarak tablolarda belirtilmiştir. Ayrıca
bu bileşenlerin olası farmakolojik etkileri literatür ışığında yorumlanmıştır.

Sonuç:
Bu araştırmanın bulguları, gelecekte süt arttırıcı veya diğer tıbbi amaçlarla
kullanılabilecek bu bitki ve bitkisel çayların farmakolojik aktif bileşenleri
üzerine yapılacak araştırmalarda yol gösterici olacaktır.

Anahtar Kelimeler

Süt arttırıcı çaylar, Rezene, Anason, Çemen otu, Isırgan tohumu, Çörek otu

Kaynakça

• 1. Tabares FP, Jaramillo JVB, Ruiz-Cortés ZT. Pharmacological overview of galactogogues. Vet Med Int. 2014;2014:602894. Doi: 10.1155/2014/6028942.Turkyılmaz C, Onal E, Hirfanoglu IM, Turan O, Koç E, Ergenekon E, Atalay Y. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med. 2011 Feb;17(2):139-42. Doi: 10.1089/acm.2010.00903. Rather MA, Dar BA, Sofi SN, Bhat BA, Qurishi MA. Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arab J Chem. 2012; 9(Supplement 2):1574–1583. Doi:10.1016/j.arabjc.2012.04.0114. Badgujar SB, Patel VV, Bandivdekar AH. Foeniculum vulgare Mill: A review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. Biomed Res Int. 2014;2014:842674. Doi: 10.1155/2014/842674.5. Koriem KMM. Approach to pharmacological and clinical applications of Anisi aetheroleum.Asian Pac J Trop Biomed.2015; 5(1):60–67.Doi: 10.1016/S2221-1691(15)30172-66. Moniruzzaman, Shahinuzzaman, Haque A, Khatun R, Yaakob Z. Gas chromatography mass spectrometry analysis and in vitro antibacterial activity of essential oil from Trigonella foenum-graecum. Asian Pac J Trop Biomed. 2015; 5(12): 1033-1036. Doi:10.1016/j.apjtb.2015.09.0107. Kıralan M, Yorulmaz A, Çalıkoğlu E, Bayrak A. Çemen otu (Trigonellafoenum-graecum L.) tohumunun yağ asitleri ve sterol bileşimi. Derim, 2017; 34(2):138-14. Doi: 10.16882/derim.2017.2849828. Wani SA, Kumar P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci. 2017; 17(2): 97–106. Doi: 10.1016/j.jssas.2016.01.0079. Bahmani M, Shirzad H, Mirhosseini M, Mesripour A, Rafieian-Kopaei M. A Review on Ethnobotanical and Therapeutic Uses of Fenugreek (Trigonellafoenum-graceum L). J Evid Based Complementary Altern Med. 2016;21(1):53-62. Doi: 10.1177/2156587215583405. 10. Al-Asadi JN. Therapeuticuses of Fenugreek (Trigonellafoencum-graecum L.).Am J Soc Issues Humanit. 2004;3(1):21–36.11. Hosseinzadeh H, Tafaghodi M, Mosavi MJ, Taghiabadi E. Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats. J Acupunct Meridian Stud. 2013;6(1):18-23. Doi: 10.1016/j.jams.2012.07.019.12. Gaya BI, Maje MI, Emmanuel SN, Muhammad UA. Lactogenic Study of The Crude Extract of Nigella Sativa Seed on Serum Prolactin Level of Lactating Albino Rats. Niger J Sci Res. 2015:14(2):85–89.13. Jalili C, Salahshoor MR, Yousefi D, Khazaei M, Shabanizadeh Darehdori A, Mokhtari T. Morphometric and Hormonal study of the effect of Utrica diocia Extract on Mammary Glands in Rats. Int J Morphol. 2015;33(3):983-987.14. Westfall RE. Galactagogue Herbs: A Qualitative study and Review. Can J Midwifery Res Pract. 2000; 2(2):22–27.15. Abascal K, Yarnell E. Botanical Galactagogues. Altern Complement Ther. 2008;14(6):288–294.16. Özcan MM, Chalchat JC. Chemical composition and antifungal effect of anise (Pimpinella anisum L.) fruit oil at ripening stage. Ann Microbiol. 2006;56(4):353–358.17. Hadi MY, Mohammed GJ, Hameed IH. Analysis of bioactive chemical compounds of Nigella sativa using gas chromatography-mass spectrometry. J Pharmacognosy Phytother. 2016,8(2):8–24. Doi:10.5897/JPP2015.036418. Rathore SS, Saxena SN, Kakani RK, Sharma LK, Agrawal D, Singh B.Genetic variation in fatty acid composition of fenugreek (Trigonella foenum-graecum L .) seed oil. Legume Research. 2017;40(4):609-617. 19. Singh O, Khanam Z, Misra N, Srivastava MK. Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn Rev. 2011;5(9):82-95. Doi: 10.4103/0973-7847.79103.20. Fitsiou E, Mitropoulou G, Spyridopoulou K, Tiptiri-Kourpeti A, Vamvakias M, Bardouki H, Panayiotidis MΙ, Galanis A, Kourkoutas Y, Chlichlia K, Pappa A. Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita. Molecules. 2016; 21(8: E1069. Doi: 10.3390/molecules2108106921. Skalicka-Woźniak K, Walasek M, Ludwiczuk A, Głowniak K. Isolation of terpenoids from Pimpinella anisum essential oil by high-performance counter-current chromatography. J Sep Sci. 2013;36(16):2611-2614. Doi: 10.1002/jssc.201300407.22. Arslan N, Gürbüz B, Sarihan EO. Variation in essential oil content and composition in Turkish anise (Pimpinella anisum l .) populations. Turk J Agric For. 2004;28(3):173–177. 23. Bano, Tabassum H, Ahmad A, Mabood A, Ahmad IZ. The medicinal significance of the bioactive compounds of Trigonella Foenum-Graecum: a review. Int J Res Ayurveda Pharm. 2016;7(4):84–91.24. Joshi BC, Mukhija M, Kalia AN. Pharmacognostical review of Urtica dioica L. J Green Pharm. 2014;8(4):201–209. 25. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Pytotherapy Res. 2000;14(5):323–328. 26. Joshi M, Nair S. HPLC analysıs of Trigonella Foenum-Graecum seeds to assess phytoestrogens. Int J Food Nutr Sci. 2014;3(1):61–64. 27. Dhouibi R, Moalla D, Ksouda K, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Affes H. Screening of analgesic activity of Tunisian Urtica dioica and analysis of its major bioactive compounds by GC/MS. Arch Physiol Biochem. 2017;20:1-9. Doi: 10.1080/13813455.2017.1402352.28. Tabanca N, Demirci B, Ozek T, Kirimer N, Baser KH, Bedir E, Khan IA, Wedge DE. Gas chromatographic-mass spectrometric analysis of essential oils from Pimpinella species gathered from central and northern Turkey. J Chromatogr A. 2006;1117(2):194-205. 29. Calapai G, Delbò M, SilanoV. Assessment report on Pimpinella anisum L.,fructus and Pimpinella anisum L., aetheroleum. Eur Med Agency. 2013;44:1–25.