EVALUATION OF INFLAMMATORY CYTOKINE AND PLASMA TITANIUM LEVELS IN DENTAL IMPLANT TREATED PATIENTS

Öz

Aim: This study aims to evaluate the corrosion properties of Titanium (Ti) dental implants in blood and also, measure the inflamatory cytocine secretion to affect of physiological corrosion on Ti implants. Method: Forty patients were divided to two groups. Group 1 was treated with the Zimmer Tapered ScrewVent implant system which has a Microtextured Ti surface. Group 2 was treated with the Implant Direct ScrewPlant implant system which has a Hydroxy Apatite surface. All implants were inserted in posterior mandibular region. Prior to implantation and 4 months after the surgery, peripheral blood samples were taken and analyzed. Results: The Ti levels of every member in the study group was increased, but not to a statistically significant degree (p>0.05). A comparison of pre- and post-dental implant applications in all study groups showed no differences for levels of serum Ti, IL-6, IL10, or TNF-alpha (p>0.05) except for IL-1 beta (p<0.05). Conclusion: No association was found between serum Ti level and implant application

Anahtar Kelimeler

• Cytokines, corrosion, dental, implant, titanium

DENTAL İMPLANTLARLA TEDAVİ EDİLEN HASTALARIN INFLAMATUAR SİTOKİN VE PLAZMA TİTANYUM SEVİYELERİNİN DEĞERLENDİRMESİ

Öz

Amaç: Bu çalışmada kanda Titanyum (Ti) dental implantların korozyon ürünlerinin ve de fizyolojik korozyonu etkileyen inflamatuar sitokin sekresyonunun Ti implantlar üzerine etkisinin değerlendirilmesi amaçlanmıştır. 

Metod: Kırk hasta iki gruba ayrıldı. Group 1 Microtextured Ti yüzeye sahip Zimmer Tapered Screw-Vent implantlar ile tedavi edildi. Group 2 Hidroksi Apatit yüzeye sahip Implant Direct ScrewPlant implant sistemi ile tedavi edildi. Bütün implantlar mandibular posterior bölgeye yerleştirildi. İmplantasyon öncesi ve cerrahiden 4 ay sonar periferal kan örnekleri alındı ve analiz edildi.

Bulgular: Çalışma gruplarının hepsinde istatiksel olarak anlamlı olmasa da artmıştır (p>0.05). Bütün gruplar implant uygulaması öncesi ve sonrası serum Ti seviyeleri karşılaştırıldığında serum IL-1 beta (p<0.05) düzeyi dışında Ti, IL-6, IL-10, ya da TNF-alfa (p>0.05) seviyelerinde artma saptanmamıştır.

Sonuç: Serum Ti seviyesi ile implant uygulanması arasında bir ilişki saptanmamıştır.

Anahtar Kelimeler

• Stokin, korozyon, dental, implant, titanyum

Kaynakça

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