İki Alman Holştayn Buzağıda Atresia Ani, Hypospadia ve Gelişmemiş Dış Genital Organlar Olgusu

Öz

Bu raporda, klinik, patolojik ve sitogenetik muayenelerinin yapıldığı Atreziya ani, hypospadia ve gelişmemiş dış genital organlar ile karakterize bir günlük erkek Alman Holştayn buzağı (HYP-AA) ile Hypospadia ve rudumenter dış genital organlar ile karakterize altı aylık erkek bir Alman Holştayn buzağı (HYP) sunulmuştur. İlk olguda (HYP-AA) anüs oluşmamıştı. İdrar yolu perineuma açılmıştı; bunun sonucu olarak, kasık bölgesinden idrar süzülüyordu. İkinci bulgu olarak, yaklaşık 10 cm'lik bir çapa sahip olan anal bölgede bir vezikül oluşumu vardı. HYP-AA-nın anal bölgesinde yapılan histopatolojik incelemede multifokal akut kanama ve yaygın ödemli nekrotizan dermatit odaklar görüldü. Klinik olarak, interstisyel pnömoni ve üretritis tespit edilmiştir. İkinci olguda ise (HYP), bir penil ve prepusyal aplazi, ventral tarafı deri tarafından kaplanmamış bifid skrotum olgusu görüldü. HYP-nin histopatolojik incelemesinde üretra epitelinde hiperplazi ve lenf nodularında foliküler hiperplazi ve üretritis gözlemlendi. HYP-nin testisi normal gelişmiş, ancak aktif spermatogenez görülmedi. HYP-AA için akrabalık katsayısı % 0.684 ve HYP-için % 5.273 ve her iki buzağının babaları ortakdı. Sonuç olarak iki olguda da meydana gelen konjenital anomaliler ortak boğa tarafından iletilen mutasyonlara bağlı olabilir.

Anahtar Kelimeler

• Atreziya ani,Hypospadia,Kalıtsal,Konjenital anomaly,Rudumenter dış genital organlar

Atresia Ani, Hypospadia and Rudimentary External Genitalia in Two German Holstein Calves

Abstract

In the present report, clinical, pathological, and cytogenetic examinations of a one-day-old male German Holstein calf with atresia ani, hypospadia and rudimentary external genitalia (HYP-AA) and a six-months-old male German Holstein calf with hypospadia and rudimentary external genitalia (HYP) are presented. In the first case (HYP-AA), an anal orifice was missing. The urethra opened in the perineum. Consequently, the inguinal region was infiltrated with urine. A secondary finding was a vesicle at the anal area with a diameter of approximately 10 cm. Histopathological examination of the anal area of the HYP-AA-calf showed a necrotizing dermatitis with multifocal acute bleedings and diffuse oedema. In addition, an interstitial pneumonia and urethritis were identified. In the clinical examination of the second case (HYP), a penile and preputial aplasia, an incomplete ventral covering by skin and a bifid scrotum were found. Histopathological examination of the HYP-calf revealed a urethritis with epithelial hyperplasia in the urethra and a follicular hyperplasia of the lymph nodes. The HYP-calf had normally developed testicles. However, there was no active spermatogenesis. The inbreeding coefficient for the HYP-AA-calf was 0.684% and for the HYP-calf 5.273% and both affected calves had one ancestor in common, a Holstein bull used in artificial insemination. In conclusion the congenital anomalies of the two cases might be due to mutations transmitted by the common ancestor.

Keywords

• Atresia ani,Congenital anomaly,Hereditary,Hypospadia,Rudimentary external genitalia

Kaynakça

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