The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues

Duygu Şahin; Nilgün Altan; Aylin Sepici-dinçel; Atilla Engin

The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues

Öz

Objective: We aimed to investigate the effcts of insulin and various doses of thyroid hormones with combine treatment on glucokinase (GK) enzyme activity, which is the one of the key enzyme in carbohydrate metabolism, diabetes and hypothyroidism.

Material and methods: Rats were assigned to eight groups: Group 1: control, Group 2: diabetes (DM), Group 3: DM + insulin, Group 4: thyroidectomized control, Group 5: thyroidectomized + DM, Group 6: thyroidectomized + DM + insulin, Group 7: thyroidectomized + DM + insulin + thyroid hormone (TH) (2.5μg/kg), Group 8: thyroidectomized + DM + insulin + TH (5 μg/kg). Glucose concentration, HbA1c and thyroid hormone levels were measured in blood samples and GK enzyme activities were determined in liver tissue samples.

Results: Our results showed that the glucokinase enzyme activities were significantly decreased in diabetic rat liver tissues compared to control group. Moreover it was observed that the enzyme activities were slightly regulated by insulin. It is demonstrated that decreased GK enzyme activity in thyroidectomized diabetic rat liver was regulated by insulin and various doses of thyroid hormones.

Conclusion: As a result the possible contribution of thyroid hormones to insulin effct to normalize diabetic induced changes in liver tissue has been shown.

Anahtar Kelimeler

Glucokinase,Thyroid hormone,Diabetes Mellitus,Rat liver

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Duygu Şahin ^*

Nilgün Altan Bu kişi benim

Aylin Sepici-dinçel Bu kişi benim

Atilla Engin Bu kişi benim

Yayımlanma Tarihi

9 Ağustos 2019

Gönderilme Tarihi

12 Mayıs 2019

Kabul Tarihi

3 Temmuz 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 2 Sayı: 3

IZ

https://izlik.org/JA32YE37KH

Kaynak Göster

RIS / Bibtex

APA

Şahin, D., Altan, N., Sepici-dinçel, A., & Engin, A. (2019). The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues. Tıp Fakültesi Klinikleri Dergisi, 2(3), 105-112. https://izlik.org/JA32YE37KH

AMA

1.Şahin D, Altan N, Sepici-dinçel A, Engin A. The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues. TFK. 2019;2(3):105-112. https://izlik.org/JA32YE37KH

Chicago

Şahin, Duygu, Nilgün Altan, Aylin Sepici-dinçel, ve Atilla Engin. 2019. “The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues”. Tıp Fakültesi Klinikleri Dergisi 2 (3): 105-12. https://izlik.org/JA32YE37KH.

EndNote

Şahin D, Altan N, Sepici-dinçel A, Engin A (01 Ağustos 2019) The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues. Tıp Fakültesi Klinikleri Dergisi 2 3 105–112.

IEEE

[1]D. Şahin, N. Altan, A. Sepici-dinçel, ve A. Engin, “The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues”, TFK, c. 2, sy 3, ss. 105–112, Ağu. 2019, [çevrimiçi]. Erişim adresi: https://izlik.org/JA32YE37KH

ISNAD

Şahin, Duygu - Altan, Nilgün - Sepici-dinçel, Aylin - Engin, Atilla. “The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues”. Tıp Fakültesi Klinikleri Dergisi 2/3 (01 Ağustos 2019): 105-112. https://izlik.org/JA32YE37KH.

JAMA

1.Şahin D, Altan N, Sepici-dinçel A, Engin A. The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues. TFK. 2019;2:105–112.

MLA

Şahin, Duygu, vd. “The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues”. Tıp Fakültesi Klinikleri Dergisi, c. 2, sy 3, Ağustos 2019, ss. 105-12, https://izlik.org/JA32YE37KH.

Vancouver

1.Duygu Şahin, Nilgün Altan, Aylin Sepici-dinçel, Atilla Engin. The Effects of Thyroid Hormones on Glucokinase Enzyme Activity in diabetic Rat Liver Tissues. TFK [Internet]. 01 Ağustos 2019;2(3):105-12. Erişim adresi: https://izlik.org/JA32YE37KH