Bor Elementi ve Biyolojik Sistemlere Etkisi

Öz

Obezite çağımızın en büyük halk sağlığı problemlerinden birisidir. Morbidite, erken ölüm, bozulmuş yaşam kalitesi ve beraberinde eşlik eden hastalıklar sağlık sistemi üzerinde büyük baskı ve sağlık bakım maliyetindeki artışlarla yük oluşturmaktadır. Günümüzde sadece estetik bir problem olarak kabul edilmeyen obezite için uygun tedavilerin geliştirilmesine yönelik çalışmalar artarak devam etmektedir. Obeziteyi tedavi etmek için etkili bir farmakolojik müdahale, sürekli kilo kaybı sağlamalı ve organlarda olumsuz yan etki oluşturmamalıdır. Bor (B) biyolojik bir eser elementtir. Bor’un biyolojik aktiviteye sahip olduğunun bilinmesi, bor içeren bileşiklerin geliştirilmesine ilgiyi arttırmıştır. Bor bazlı ilaçların birçok biyomedikal uygulamaya sahip olduğu gösterilmiştir. Bor’un biyolojik rolü henüz tam olarak açıklığa kavuşmamış olsa da, Bor’un trigliserid, glikoz, üre, kreatinin, steroid hormon seviyelerini ve çeşitli metabolik enzimlerin aktivitesini değiştirebileceği gözlenmiştir. Bor’un kilo verme üzerindeki olası etkisini ortaya koymak üzere hayvan ve insan çalışmaları yürütülmektedir. Bu derlemede bor elementinin biyolojik sistemlerdeki etkisi ve obezite tedavisinde kullanımı ile ilgili bilgilerin derlenmesi amaçlanmıştır.

Anahtar Kelimeler

• Bor
• Bor elementi
• Borik asit
• Obezite

Boron Element and Its Effect on Biological Systems

Öz

Obesity is one of the biggest public health problems of our age. Morbidity, premature death, impaired quality of life and accompanying diseases are burdened by enormous pressure on the health system and increases in health care costs. Nowadays, studies to develop appropriate treatments for obesity, which is not only considered an aesthetic problem, are increasingly continuing. An effective pharmacological intervention to treat obesity should provide sustained weight loss and not have negative side effects on organs. Boron (B) is a biological trace element. Knowing that boron has biological activity has increased interest in the development of boron-containing compounds. Boron-based drugs have been shown to have many biomedical applications. Although the biological role of boron has not been fully clarified yet, it has been observed that boron can alter triglyceride, glucose, urea, creatinine, steroid hormone levels and the activity of various metabolic enzymes. Animal and human studies are being conducted to reveal the possible effect of boron on weight loss. In this review, it is aimed to compile information about the effect of boron in biological systems and its use in the treatment of obesity.

Anahtar Kelimeler

• Boron
• Boron element
• Boric acid
• Obesity

Kaynakça

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