Flavonoidler, bitkileri zararlı etkenlere karşı koruyan biyoaktif bileşenlerdir. Sebze, meyve ve tahıllarda bol miktarda bulunan flavonoidlerin; antiinflamatuar, antioksidan, antidiyabetik, antihipertansif, antimikrobiyal olmak üzere birçok önemli özelliklere sahip oldukları saptanmıştır. Bu özellikleri nedeniyle flavonoidler, kanser başta olmak üzere kardiyovasküler hastalıklar, diyabet, obezite gibi bulaşıcı olmayan kronik hastalıkların önlenmesinde ve tedavisinde önem taşımaktadır. Son yıllarda doğal bitkisel tedavilere artan talep ve kansere bağlı ölümlerin artması ile birlikte flavonoidlerin kanser üzerindeki etkileri çalışmalarda sıklıkla araştırılan bir konu haline gelmiştir. Bu derlemede, flavonoidlerin kanser gelişimi ve seyri üzerindeki etkilerini ele alan çalışmalar incelenmiştir.
Arul, D., & Subramanian, P. (2013). Naringenin (Citrus Flavonone) İnduces Growth İnhibition, Cell Cycle Arrest And Apoptosis İn Human Hepatocellular Carcinoma Cells. Pathology Oncology Research : Por, 19(4), 763–770. Https://Doi.Org/10.1007/S12253-013-9641-1
Baião, D., de Freitas, C. S., Gomes, L. P., da Silva, D., Correa, A., Pereira, P. R., Aguila, E., & Paschoalin, V. (2017). Polyphenols from Root, Tubercles and Grains Cropped in Brazil: Chemical and Nutritional Characterization and Their Effects on Human Health and Diseases. Nutrients, 9(9), 1044. https://doi.org/10.3390/nu9091044
Barreca, D., Gattuso, G., Bellocco, E., Calderaro, A., Trombetta, D., Smeriglio, A., Laganà, G., Daglia, M., Meneghini, S., & Nabavi, S. M. (2017). Flavanones: Citrus Phytochemical With Health-Promoting Properties. Biofactors (Oxford, England), 43(4), 495–506. Https://Doi.Org/10.1002/Biof.1363
Çimen F., Polat H., Ekici L. (2020). Polifenollerin Bağırsak Mikrobiyota Kompozisyonunu Düzenleyici ve Nöroprotektif Etkileri. Akademik Gıda, 18 (2), 190-208. DOI: 10.24323/akademik-gida.758838
Demir T, Akpınar Ö. (2022). Bitkilerde Bulunan Fitokimyasalların Biyolojik Aktiviteleri. Türk-Tarım, Gıda, Bilim ve Teknoloji Dergisi, 8(8), 1734-1746. Doi: 1024925/turjaf.v8i8. 1734-1746.3484
Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., & Restani, P. (2021). Polyphenols and Human Health: The Role of Bioavailability. Nutrients, 13(1), 273. https://doi.org/10.3390/nu13010273
Forni, C., Rossi, M., Borromeo, I., Feriotto, G., Platamone, G., Tabolacci, C., Mischiati, C., & Beninati, S. (2021). Flavonoids: A Myth or a Reality for Cancer Therapy?.Molecules (Basel, Switzerland), 26(12), 3583. https://doi.org/10.3390/molecules26123583
Ganesan, K., & Xu, B. (2017). A Critical Review on Polyphenols and Health Benefits of Black Soybeans. Nutrients, 9(5), 455. https://doi.org/10.3390/nu9050455
Greten, F.R., Grivennikov, S.I. (2019). Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Immunity, 51(1), 27-41. https://doi.org/10.1016/j.immuni.2019.06.025.
Gold-Smith, F., Fernandez, A., & Bishop, K. (2016). Mangiferin and Cancer: Mechanisms of Action. Nutrients, 8(7), 396. https://doi.org/10.3390/nu8070396
Hostetler, G. L., Ralston, R. A., & Schwartz, S. J. (2017). Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity. Advances in nutrition (Bethesda, Md.), 8(3), 423–435. https://doi.org/10.3945/an.116.012948
Islam, J., Shree, A., Vafa, A., Afzal, S. M., & Sultana, S. (2021). Taxifolin ameliorates Benzo[a]pyrene-induced lung injury possibly via stimulating the Nrf2 signalling pathway. International immunopharmacology, 96, 107566. https://doi.org/10.1016/j.intimp.2021.107566
Kuhnle G. (2018). Nutrition epidemiology of flavan-3-ols: The known unknowns. Molecular aspects of medicine, 61, 2–11. https://doi.org/10.1016/j.mam.2017.10.003
Kumar, S., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids: an overview. TheScientificWorldJournal, 2013, 162750. https://doi.org/10.1155/2013/162750
Lei, L., Yang, Y., He, H., Chen, E., Du, L., Dong, J., & Yang, J. (2016). Flavan-3-ols consumption and cancer risk: A meta-analysis of epidemiologic studies. Oncotarget, 7(45), 73573–73592. https://doi.org/10.18632/oncotarget.12017
Liu R. H. (2013). Health-promoting components of fruits and vegetables in the diet. Advances in nutrition (Bethesda, Md.), 4(3), 384S–92S. https://doi.org/10.3945/an.112.003517
Liu, H., Dong, Y., Gao, Y., Du, Z., Wang, Y., Cheng, P., Chen, A., & Huang, H. (2016). The Fascinating Effects Of Baicalein On Cancer: A Review. International Journal Of Molecular Sciences, 17(10), 1681. Https://Doi.Org/10.3390/İjms17101681
Mohammed, F. S., Günal, S., Pehlivan, M., Doğan, M., Sevindik, M. & Akgül, H. (2020). Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science, 33 (4), 670-677. DOI: 10.35378/gujs.707555
Pan, H., Hu, Q., Wang, J., Liu, Z., Wu, D., Lu, W., & Huang, J. (2016). Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity. Biochemical and biophysical research communications, 477(4), 915–922. https://doi.org/10.1016/j.bbrc.2016.06.158
Pichler, C., Ferk, F., Al-Serori, H., Huber, W., Jäger, W., Waldherr, M., Mišík, M., Kundi, M., Nersesyan, A., Herbacek, I., & Knasmueller, S. (2017). Xanthohumol Prevents DNA Damage by Dietary Carcinogens: Results of a Human Intervention Trial. Cancer prevention research (Philadelphia, Pa.), 10(2), 153–160. https://doi.org/10.1158/1940-6207.CAPR-15-0378
Rock, C. L., Thomson, C., Gansler, T., Gapstur, S. M., McCullough, M. L., Patel, A. V., Andrews, K. S., Bandera, E. V., Spees, C. K., Robien, K., Hartman, S., Sullivan, K., Grant, B. L.,
Hamilton, K. K., Kushi, L. H., Caan, B. J., Kibbe, D., Black, J. D., Wiedt, T. L., McMahon, C., … Doyle, C. (2020). American Cancer Society guideline for diet and physical activity for cancer prevention. CA: a cancer journal for clinicians, 70(4), 245–271. https://doi.org/10.3322/caac.21591
Samavat, H., Ursin, G., Emory, T. H., Lee, E., Wang, R., Torkelson, C. J., Dostal, A. M., Swenson, K., Le, C. T., Yang, C. S., Yu, M. C., Yee, D., Wu, A. H., Yuan, J. M., & Kurzer, M. S. (2017). A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer. Cancer prevention research (Philadelphia, Pa.), 10(12), 710–718. https://doi.org/10.1158/1940-6207.CAPR-17-0187
Suna, G., & Ayaz, A. (2019). Turunçgil Flavonoidlerinin Kardiyovasküler Sağlık Üzerine Etkileri. Beslenme ve Diyet Dergisi, 47(2), 99-107. Https://Doi.Org/10.33076/2019.Bdd.511
Tahir, M. S., Almezgagi, M., Zhang, Y., Bashir, A., Abdullah, H. M., Gamah, M., Wang, X., Zhu, Q., Shen, X., Ma, Q., Ali, M., Solangi, Z. A., Malik, W. S., & Zhang, W. (2021). Mechanistic new insights of flavonols on neurodegenerative diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 137, 111253. https://doi.org/10.1016/j.biopha.2021.111253
Torricelli, P., Elia, A. C., Magara, G., Feriotto, G., Forni, C., Borromeo, I., De Martino, A., Tabolacci, C., Mischiati, C., & Beninati, S. (2021). Reduction Of Oxidative Stress And Ornithine Decarboxylase Expression İn A Human Prostate Cancer Cell Line Pc-3 By A Combined Treatment With Α-Tocopherol And Naringenin. Amino Acids, 53(1), 63–72. Https://Doi.Org/10.1007/S00726-020-02925-1
Wallace, T. C., & Giusti, M. M. (2015). Anthocyanins. Advances in nutrition (Bethesda, Md.), 6(5), 620–622. https://doi.org/10.3945/an.115.009233
World Health Organization (WHO). Factsheed: Cancer. (2022). Erişim: 01.06.2022 https://www.who.int/health-topics/cancer#tab=tab_1
Yu, J., Bi, X., Yu, B., & Chen, D. (2016). Isoflavones: Anti-Inflammatory Benefit And Possible Caveats. Nutrients, 8(6), 361. Https://Doi.Org/10.3390/Nu8060361
Yuvaraj, S., Ramprasath, T., Saravanan, B., Vasudevan, V., Sasikumar, S., & Selvam, G. S. (2021). Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats. Molecular and cellular biochemistry, 476(7), 2719–2727. https://doi.org/10.1007/s11010-021-04105-5
Zakaryan, H., Arabyan, E., Oo, A., & Zandi, K. (2017). Flavonoids: promising natural compounds against viral infections. Archives of virology, 162(9), 2539–2551. https://doi.org/10.1007/s00705-017-3417-y
Zhang, F. F., Haslam, D. E., Terry, M. B., Knight, J. A., Andrulis, I. L., Daly, M. B., Buys, S. . S., & John, E. M. (2017). Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry. Cancer, 123(11), 2070–2079.
Zhao, H., Wu, L., Yan, G. et al. (2021). Inflammation and tumor progression: signaling pathways and targeted intervention. Sig Transduct Target Ther 6, 263 https://doi.org/10.1038/s41392-021-00658-5
Şengün, F. Ş., & Özenoğlu, A. (2022). Flavonoidlerin Kanser Gelişimi ve Seyri Üzerine Etkileri. Avrasya Sağlık Bilimleri Dergisi, 6(1), 57-65. https://doi.org/10.53493/avrasyasbd.1164133
AMA
Şengün FŞ, Özenoğlu A. Flavonoidlerin Kanser Gelişimi ve Seyri Üzerine Etkileri. AvrasyaSBD. Aralık 2022;6(1):57-65. doi:10.53493/avrasyasbd.1164133
Chicago
Şengün, Fatmanur Şirin, ve Aliye Özenoğlu. “Flavonoidlerin Kanser Gelişimi Ve Seyri Üzerine Etkileri”. Avrasya Sağlık Bilimleri Dergisi 6, sy. 1 (Aralık 2022): 57-65. https://doi.org/10.53493/avrasyasbd.1164133.
EndNote
Şengün FŞ, Özenoğlu A (01 Aralık 2022) Flavonoidlerin Kanser Gelişimi ve Seyri Üzerine Etkileri. Avrasya Sağlık Bilimleri Dergisi 6 1 57–65.
IEEE
F. Ş. Şengün ve A. Özenoğlu, “Flavonoidlerin Kanser Gelişimi ve Seyri Üzerine Etkileri”, AvrasyaSBD, c. 6, sy. 1, ss. 57–65, 2022, doi: 10.53493/avrasyasbd.1164133.
ISNAD
Şengün, Fatmanur Şirin - Özenoğlu, Aliye. “Flavonoidlerin Kanser Gelişimi Ve Seyri Üzerine Etkileri”. Avrasya Sağlık Bilimleri Dergisi 6/1 (Aralık 2022), 57-65. https://doi.org/10.53493/avrasyasbd.1164133.
JAMA
Şengün FŞ, Özenoğlu A. Flavonoidlerin Kanser Gelişimi ve Seyri Üzerine Etkileri. AvrasyaSBD. 2022;6:57–65.
MLA
Şengün, Fatmanur Şirin ve Aliye Özenoğlu. “Flavonoidlerin Kanser Gelişimi Ve Seyri Üzerine Etkileri”. Avrasya Sağlık Bilimleri Dergisi, c. 6, sy. 1, 2022, ss. 57-65, doi:10.53493/avrasyasbd.1164133.
Vancouver
Şengün FŞ, Özenoğlu A. Flavonoidlerin Kanser Gelişimi ve Seyri Üzerine Etkileri. AvrasyaSBD. 2022;6(1):57-65.