Glutamin Eneması İshalli Buzağılarda Bağırsak Mukozal Hasarının Tersine Çevrilmesine Yardımcı Olmuş Olabilir: 'Mikrobiyota-Bağırsak-Beyin Ekseni' İçin Trofik Aminoasit

Yıl 2025, Cilt: 8 Sayı: 3, 171 - 176, 30.09.2025

Deniz Alıç Ural

https://doi.org/10.53493/avrasyasbd.1711822

Öz

Giriş: Glutamin (Gln), hayvanların gastrointestinal bariyer fonksiyonunu iyileştirmek için etkili bir besin takviyesi olarak gösterilmiştir. Amaç: Bu çalışmada, ishalli buzağılarda gastrointestinal toksisite ve intestinal mukozal hasarı tespit etmek için değerli bir belirteç olan Diamin oksidaz (dAo) ile tespit edilen intestinal morfoloji üzerindeki Gln'nin etkinliği değerlendirilmiştir. Materyal ve Metot: Etiyolojisi bilinmeyen toplam 20 buzağı bu çalışmaya dahil edildi. Teknik müdahale dışında herhangi bir müdahalede bulunmayan kurul onaylı veteriner cerrahlar tarafından yapılan fiziksel muayenenin ardından, herhangi bir sorumlu etiyolojik ajan tespit edilmeden hızlı tanı test kitleri uygulandı ve her buzağıdan toplam 0,9 ml kan alındı. Ticari olarak temin edilebilen sığır dAo test kitleri kullanılarak sandviç ELISA'nın mevcut olduğu kabul edildi. Bulgular: Glutamin (Gut-cumin I Liquid Sol.) 7 ardışık gün boyunca rektal yoldan 15 mg/kg olarak verildi. Ortalama± SE dAo (ng/mL) analizi 0. günde (denemenin başlangıcı) ve birincil son noktada (7. gün) mevcut kabul edildi, sırasıyla 9,12±2,46'ya karşı 28,19±3,18 (p<0,01) sunuldu. Sonuç: dAo seviyeleriyle tespit edildiği gibi, ishalli buzağılarda bağırsak mukozal hasarının tersine çevrilmesine yardımcı olabilecek bir trofik aminoasit olan glutaminin önerilmesi akıllıca olmamalıdır. Öne Çıkanlar: Glutamin bağırsak hasarında tamir edici bir molekül ve yem katkı maddesi olabilir.

Anahtar Kelimeler

bağırsak , diamin oksidaz , glutamin , hasar , ishal

Glutamin Enema Might Have Helped Reversing İntestinal Mucosal İnjury Among Diarrheic Calves: Trophic Aminoacid For ‘Microbiota-Gut-Brain Axis’

Öz

Introduction: Glutamine (Gln) has been denoted as an effectual nutritional supplementation for improving the gastrointestinal barrier function of animals. Aim: In the present study evaluating the efficacy of Gln on intestinal morphology, as detected by Diamine oxidase (dAo), a valuable marker for detecting gastrointestinal toxicity and intestinal mucosal injury, among diarrheic calves. Materials and Methods: In a total of 20 calves with diarrhea, with unknown etiology, were enrolled at this study. Following physical examination performed by board certified veterinary surgeons (who were not involved other than technical intervention), rapid diagnostic test kits were applied without any responsible etiological agent detected, a total of 0.9 ml blood was withdrawn from each calf. Sandwich ELISA by use of commercially available bovine dAo test kits were deemed available. Glutamine (Gut-cumin I Liquid Sol.) was given via rectal route as 15 mg/kg for 7 consequtive days. Results: Mean± SE dAo (ng/mL) analysis were deemed available at days 0 (start of trial) and primary end point (day 7), presented 9.12±2.46 vs. 28.19±3.18 (p<0,01), respectively. Conclusion: It should not be unwise to draw suggestion that a trophic aminoacid, glutamine, might have helped reversing intestinal mucosal injury among diarrheic calves as detected by dAo levels. Highlights: Glutamine may be a repair molecule and feed additive in intestinal damage.

Anahtar Kelimeler

damage , intestine , glutamine , diamine oxidase , diarrhea

Kaynakça

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