Antioxidative capacities of some GABAA receptor modulating food plants

Yıl 2019, Cilt: 8 Sayı: 2, 237 - 242, 20.12.2019

Sümeyye Şahin

https://doi.org/10.29278/azd.602839

Öz

Reactive oxygen species cause oxidative stress associated with some
health issues such as neurodegenerative diseases. Some antioxidants show
neuroprotective activity and regulate neuronal activity through positive
modulation of GABA_A receptors. In this study, the antioxidative capacity of some novel GABA_A
receptor modulating food plants, including lavender, clove and four Sideritis species (S. arguta, S. sipylea, S. condensata, and S.
stricta) was investigated using ABTS assay. The aqueous clove extract
showed the most potent antioxidant effect and its IC₅₀ value was
found to be 3.76 μg/mL. The antioxidant capacity of Trolox was lower (IC₅₀:
4.63 μg/mL) than that of the clove extract, but higher than those of the other
food extracts. The aqueous lavender extract exhibited less antioxidant activity
compared to Sideritis species, except
S. sipylea that had the least
antioxidant capacity (IC₅₀: 20.75 μg/mL). In conclusion, these
results confirm that GABA_Areceptor modulating food plants possess strong antioxidative activity.

Anahtar Kelimeler

Sideritis, Lavanta, Karanfil

Kaynakça

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