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Evaluation of the Effectiveness of Venous Thromboembolism Prophylaxis in Patients Undergoing Major Urological Surgery

Yıl 2024, Cilt: 13 Sayı: 3, 490 - 496, 25.12.2024
https://doi.org/10.53424/balikesirsbd.1468790

Öz

Objective: To evaluate the effectiveness of venous thromboembolism prophylaxis in patients undergoing majör urologic surgery. Materials and Methods: Data of patients who underwent major urological surgery between January 2018 and October 2023 were analyzed. Intraoperative age, body mass index, and comorbidities were recorded. All patients received prophylaxis with low molecular weight heparin and graduated compression stockings starting in the preoperative period until mobilization in the postoperative period. The patients' historical data were reviewed, and the development of venous thromboembolism in the one-month postoperative period was investigated. Results: Nephrectomy was performed in 156 patients (45.2%), radical prostatectomy in 142 patients (41.2%), partial nephrectomy in 28 patients (8.1%), and radical cystectomy in 19 patients (5.5%). The mean age at the time of operation was 66.06±9.43 years, and the body mass index was 27.06±4.22. Hypertension was found in 51.6%, diabetes mellitus in 26.1%, coronary artery disease in 13.9%, chronic obstructive pulmonary disease in 8.1%, atrial fibrillation in 2.1%, and valvular heart disease in 1.2%. In the postoperative period, two patients developed pulmonary embolism, and one patient developed deep vein thrombosis. One of the patients with pulmonary embolism had undergone radical prostatectomy, and the other patients had undergone radical cystectomy. There was no mortality after treatment. Conclusion: Venous thromboembolism is highly preventable when appropriate precautions and prophylaxis are taken. In our study, the incidence of pulmonary embolism and deep vein thrombosis was similar to the literature.

Kaynakça

  • Al-Mugheed, K. A., & Bayraktar, N. (2018). Knowledge and practices of nurses on deep vein thrombosis risks and prophylaxis: a descriptive cross sectional study. Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing, 36(2), 71–80. https://doi.org/10.1016/J.JVN.2018.02.001
  • Amin, A. N., Lenhart, G., Princic, N., Lin, J., Thompson, S., & Johnston, S. (2011). Retrospective administrative database study of the time period of venous thromboembolism risk during and following hospitalization for major orthopedic or abdominal surgery in real-world US patients. Hospital Practice (1995), 39(2), 7–16. https://doi.org/10.3810/HP.2011.04.390
  • Bochner, B. H., Dalbagni, G., Sjoberg, D. D., Silberstein, J., Keren Paz, G. E., Donat, S. M. H., Coleman, J. A., Mathew, S., Vickers, A., Schnorr, G. C., Feuerstein, M. A., Rapkin, B., Parra, R. O., Herr, H. W., & Laudone, V. P. (2015). Comparing open radical cystectomy and robot-assisted laparoscopic radical cystectomy: a randomized clinical trial. European Urology, 67(6), 1042–1050. https://doi.org/10.1016/J.EURURO.2014.11.043
  • Cano Garcia, C., Tappero, S., Piccinelli, M. L., Barletta, F., Incesu, R. B., Morra, S., Scheipner, L., Baudo, A., Tian, Z., Hoeh, B., Chierigo, F., Sorce, G., Saad, F., Shariat, S. F., Carmignani, L., Ahyai, S., Longo, N., Tilki, D., Briganti, A., … Karakiewicz, P. I. (2023). In-hospital venous thromboembolism and pulmonary embolism after major urologic cancer surgery. Annals of Surgical Oncology, 30(13), 8770–8779. https://doi.org/10.1245/S10434-023-14246-0/TABLES/5
  • Chen, E. C., Papa, N., Lawrentschuk, N., Bolton, D., & Sengupta, S. (2016). Incidence and risk factors of venous thromboembolism after pelvic uro-oncologic surgery–a single center experience. BJU International, 117, 50–53. https://doi.org/10.1111/BJU.13238
  • Cindolo, L., Salzano, L., Mirone, V., Imbimbo, C., Longo, N., Kakkos, S. K., & Reddy, D. J. (2009). Thromboprophylaxis in radical retropubic prostatectomy: efficacy and patient compliance of a dual modality. Urologia Internationalis, 83(1), 12–18. https://doi.org/10.1159/000224861
  • Dai, J. C., Morgan, T. N., Kusin, S., Kommidi, V., Garbens, A., Cadeddu, J. A., & Gahan, J. C. (2021). Use of pre-operative pharmacologic venous thromboembolism prophylaxis for robotic partial nephrectomy. Urology, 154, 177–183. https://doi.org/10.1016/J.UROLOGY.2021.03.043
  • Devereaux, P. J., Mrkobrada, M., Sessler, D. I., Leslie, K., Alonso-Coello, P., Kurz, A., Villar, J. C., Sigamani, A., Biccard, B. M., Meyhoff, C. S., Parlow, J. L., Guyatt, G., Robinson, A., Garg, A. X., Rodseth, R. N., Botto, F., Lurati Buse, G., Xavier, D., Chan, M. T. V., … Yusuf, S. (2014). Aspirin in patients undergoing noncardiac surgery. The New England Journal of Medicine, 370(16), 1494–1503. https://doi.org/10.1056/NEJMOA1401105
  • Forrest, J. B., Clemens, J. Q., Finamore, P., Leveillee, R., Lippert, M., Pisters, L., Touijer, K., & Whitmore, K. (2009). AUA best practice statement for the prevention of deep vein thrombosis in patients undergoing urologic surgery. The Journal of Urology, 181(3), 1170–1177. https://doi.org/10.1016/J.JURO.2008.12.027
  • Golemi, I., Salazar Adum, J. P., Tafur, A., & Caprini, J. (2019). Venous thromboembolism prophylaxis using the caprini score. Disease-a-Month : DM, 65(8), 249–298. https://doi.org/10.1016/J.DISAMONTH.2018.12.005
  • Irmak, B., Karadag, M., & Yildiz Emre, N. (2022). The risk factors for preoperative and postoperative deep vein thrombosis in surgical patients. Clinical and Experimental Health Sciences, 12, 120–127. https://doi.org/10.33808/clinexphealthsci.839430
  • Kakkos, S., Kirkilesis, G., Caprini, J. A., Geroulakos, G., Nicolaides, A., Stansby, G., & Reddy, D. J. (2022). Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism. The Cochrane Database of Systematic Reviews, 1(1). https://doi.org/10.1002/14651858.CD005258.PUB4
  • Mossanen, M., Krasnow, R. E., Zlatev, D. V., Tan, W. S., Preston, M. A., Trinh, Q. D., Kibel, A. S., Sonpavde, G., Schrag, D., Chung, B. I., & Chang, S. L. (2019). Examining the relationship between complications and perioperative mortality following radical cystectomy: a population-based analysis. BJU International, 124(1), 40–46. https://doi.org/10.1111/BJU.14636
  • Naik, R., Mandal, I., Hampson, A., Lane, T., Adshead, J., Rai, B. P., & Vasdev, N. (2019). The role of extended venous thromboembolism prophylaxis for major urological cancer operations. BJU International, 124(6), 935–944. https://doi.org/10.1111/BJU.14906
  • Nam, J. H., Kim, D. H., Yoo, J. H., Hwang, J. H., & Chang, J. D. (2017). Does preoperative mechanical prophylaxis have additional effectiveness in preventing postoperative venous thromboembolism in elderly patients with hip fracture?-Retrospective case-control study. PloS One, 12(11). https://doi.org/10.1371/JOURNAL.PONE.0187337
  • Oh, H., Boo, S., & Lee, J. A. (2017). Clinical nurses’ knowledge and practice of venous thromboembolism risk assessment and prevention in South Korea: a cross-sectional survey. Journal of Clinical Nursing, 26(3–4), 427–435. https://doi.org/10.1111/JOCN.13424
  • Pastori, D., Cormaci, V. M., Marucci, S., Franchino, G., Del Sole, F., Capozza, A., Fallarino, A., Corso, C., Valeriani, E., Menichelli, D., & Pignatelli, P. (2023). A Comprehensive Review of Risk Factors for Venous Thromboembolism: From Epidemiology to Pathophysiology. International Journal of Molecular Sciences, 24(4). https://doi.org/10.3390/IJMS24043169
  • Rausa, E., Kelly, M. E., Asti, E., Aiolfi, A., Bonitta, G., Winter, D. C., & Bonavina, L. (2018). Extended versus conventional thromboprophylaxis after major abdominal and pelvic surgery: systematic review and meta-analysis of randomized clinical trials. Surgery, 164(6), 1234–1240. https://doi.org/10.1016/J.SURG.2018.05.028
  • Reinke, C. E., Drebin, J. A., Kreider, S., Kean, C., Resnick, A., Raper, S., & Kelz, R. R. (2012). Timing of preoperative pharmacoprophylaxis for pancreatic surgery patients: a venous thromboembolism reduction initiative. Annals of Surgical Oncology, 19(1), 19–25. https://doi.org/10.1245/S10434-011-1858-1/TABLES/4
  • Rice, K. R., Brassell, S. A., & McLeod, D. G. (2010). Venous thromboembolism in urologic surgery: prophylaxis, diagnosis, and treatment. Reviews in Urology, 12(2–3), e111. https://doi.org/10.3909/riu0472
  • Sertkaya, Z. & Öztürk, M. (2014). Ürolojik Cerrahilerde Venöz Tromboembolizm. Endouroloji Bulteni, 135-138. https://doi.org/10.530/endo2014070307
  • Shakiba, B., Faegh, A., Emami, S., Heidari, K., & Maghsoudi, R. (2024). Procedure-Specific Thromboprophylaxis in urological surgeries: a narrative review. Urology Journal. https://doi.org/10.22037/UJ.V20I.8068
  • Speth, J. (2023). Guidelines in practice: prevention of venous thromboembolism. AORN Journal, 118(5), 321–328. https://doi.org/10.1002/AORN.14019
  • Sweetland, S., Green, J., Liu, B., De González, A. B., Canonico, M., Reeves, G., & Beral, V. (2009). Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. British Medical Journal (Clinical Research Ed.), 339(7736), 32. https://doi.org/10.1136/BMJ.B4583
  • Tikkinen, K. A. O., Agarwal, A., Craigie, S., Cartwright, R., Gould, M. K., Haukka, J., Naspro, R., Novara, G., Sandset, P. M., Siemieniuk, R. A., Violette, P. D., & Guyatt, G. H. (2014). Systematic reviews of observational studies of risk of thrombosis and bleeding in urological surgery (ROTBUS): introduction and methodology. Systematic Reviews, 3(1). https://doi.org/10.1186/2046-4053-3-150
  • Tikkinen, K. A. O., Cartwright, R., Gould, M. K., Naspro, R., Novara, G., Sandset, P. M., Violette, P. D., & Guyatt, G. H. (2022). EAU guidelines on thromboprophylaxis in urological surgery. https://uroweb.org/eau-guidelines/discontinued-topics/thromboprophylaxis
  • Tikkinen, K. A. O., Craigie, S., Agarwal, A., Siemieniuk, R. A. C., Cartwright, R., Violette, P. D., Novara, G., Naspro, R., Agbassi, C., Ali, B., Imam, M., Ismaila, N., Kam, D., Gould, M. K., Sandset, P. M., & Guyatt, G. H. (2018). Procedure-specific risks of thrombosis and bleeding in urological non-cancer surgery: systematic review and meta-analysis. European Urology, 73(2), 236–241. https://doi.org/10.1016/J.EURURO.2017.02.025
  • Tikkinen, K. A. O., Craigie, S., Agarwal, A., Violette, P. D., Novara, G., Cartwright, R., Naspro, R., Siemieniuk, R. A. C., Ali, B., Eryuzlu, L., Geraci, J., Winkup, J., Yoo, D., Gould, M. K., Sandset, P. M., & Guyatt, G. H. (2018). Procedure-specific risks of thrombosis and bleeding in urological cancer surgery: systematic review and meta-analysis. European Urology, 73(2), 242–251. https://doi.org/10.1016/J.EURURO.2017.03.008
  • Violette, P. D., Cartwright, R., Briel, M., Tikkinen, K. A. O., & Guyatt, G. H. (2016). Guideline of guidelines: thromboprophylaxis for urological surgery. BJU International, 118(3), 351–358. https://doi.org/10.1111/BJU.13496

Majör Ürolojik Cerrahi Geçiren Hastalara Uygulanan Venöz Tromboemboli Profilaksisinin Etkinliğinin Değerlendirilmesi

Yıl 2024, Cilt: 13 Sayı: 3, 490 - 496, 25.12.2024
https://doi.org/10.53424/balikesirsbd.1468790

Öz

Amaç: Araştırmada majör ürolojik cerrahi geçiren hastalara uygulanan venöz tromboemboli profilaksisinin etkinliğinin değerlendirilmesi amaçlandı. Gereç Yöntem: Ocak 2018 ve Ekim 2023 tarihleri arasında majör ürolojik cerrahi geçiren hastaların verileri incelendi. Hastaların operasyon sırasındaki yaşları, vücut kitle indeksleri, ek hastalıklarına dair veriler kaydedildi. Tüm hastalara postoperatif dönemde mobilize olana kadar preoperatif dönemde başlanarak düşük molekül ağırlıklı heparin ve dizüstü varis çorabı ile profilaksi uygulandı. Hastaların geçmiş verileri taranarak operasyon sonrası bir aylık periyodda venöz tromboemboli gelişip gelişmediği araştırıldı. Bulgular: Hastaların 156’sına (%45,2) nefrektomi, 142’sine (%41,2) radikal prostatektomi, 28 hastaya (%8,1) parsiyel nefrektomi ve 19 hastaya (%5,5) radikal sistektomi yapıldığı saptandı. Hastaların operasyon sırasındaki yaş ortalaması 66,06 ±9,43, vücut kitle indeksleri 27,06±4,22 olarak saptandı. Ameliyat edilen hastalarda %51,6 hipertansiyon, %26,1 Diyabetes Mellitus, %13,9 Koroner arter hastalığı, %8,1 Kronik obstrüktif akciğer hastalığı, %2,1 atriyal fibrilasyon, %1,2 kalp kapak hastalığı saptandı. Postoperatif dönemde 2 hastada pulmoner emboli ve 1 hastada derin ven trombozu geliştiği saptandı, pulmoner emboli gelişen hastalardan biri radikal prostatektomi, diğer hastalar ise radikal sistektomi operasyonu geçirmişti. Tedavi sonrası hastalarda mortalite gelişmedi. Sonuç: Venöz tromboembolizm uygun önlemler alınıp profilaksi uygulandığı zaman yüksek oranda önlenebilir bir durumdur. Çalışmamızda da pulmoner emboli ve derin ven trombozu görülme sıklığı literatür ile benzer olarak saptanmıştır.

Kaynakça

  • Al-Mugheed, K. A., & Bayraktar, N. (2018). Knowledge and practices of nurses on deep vein thrombosis risks and prophylaxis: a descriptive cross sectional study. Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing, 36(2), 71–80. https://doi.org/10.1016/J.JVN.2018.02.001
  • Amin, A. N., Lenhart, G., Princic, N., Lin, J., Thompson, S., & Johnston, S. (2011). Retrospective administrative database study of the time period of venous thromboembolism risk during and following hospitalization for major orthopedic or abdominal surgery in real-world US patients. Hospital Practice (1995), 39(2), 7–16. https://doi.org/10.3810/HP.2011.04.390
  • Bochner, B. H., Dalbagni, G., Sjoberg, D. D., Silberstein, J., Keren Paz, G. E., Donat, S. M. H., Coleman, J. A., Mathew, S., Vickers, A., Schnorr, G. C., Feuerstein, M. A., Rapkin, B., Parra, R. O., Herr, H. W., & Laudone, V. P. (2015). Comparing open radical cystectomy and robot-assisted laparoscopic radical cystectomy: a randomized clinical trial. European Urology, 67(6), 1042–1050. https://doi.org/10.1016/J.EURURO.2014.11.043
  • Cano Garcia, C., Tappero, S., Piccinelli, M. L., Barletta, F., Incesu, R. B., Morra, S., Scheipner, L., Baudo, A., Tian, Z., Hoeh, B., Chierigo, F., Sorce, G., Saad, F., Shariat, S. F., Carmignani, L., Ahyai, S., Longo, N., Tilki, D., Briganti, A., … Karakiewicz, P. I. (2023). In-hospital venous thromboembolism and pulmonary embolism after major urologic cancer surgery. Annals of Surgical Oncology, 30(13), 8770–8779. https://doi.org/10.1245/S10434-023-14246-0/TABLES/5
  • Chen, E. C., Papa, N., Lawrentschuk, N., Bolton, D., & Sengupta, S. (2016). Incidence and risk factors of venous thromboembolism after pelvic uro-oncologic surgery–a single center experience. BJU International, 117, 50–53. https://doi.org/10.1111/BJU.13238
  • Cindolo, L., Salzano, L., Mirone, V., Imbimbo, C., Longo, N., Kakkos, S. K., & Reddy, D. J. (2009). Thromboprophylaxis in radical retropubic prostatectomy: efficacy and patient compliance of a dual modality. Urologia Internationalis, 83(1), 12–18. https://doi.org/10.1159/000224861
  • Dai, J. C., Morgan, T. N., Kusin, S., Kommidi, V., Garbens, A., Cadeddu, J. A., & Gahan, J. C. (2021). Use of pre-operative pharmacologic venous thromboembolism prophylaxis for robotic partial nephrectomy. Urology, 154, 177–183. https://doi.org/10.1016/J.UROLOGY.2021.03.043
  • Devereaux, P. J., Mrkobrada, M., Sessler, D. I., Leslie, K., Alonso-Coello, P., Kurz, A., Villar, J. C., Sigamani, A., Biccard, B. M., Meyhoff, C. S., Parlow, J. L., Guyatt, G., Robinson, A., Garg, A. X., Rodseth, R. N., Botto, F., Lurati Buse, G., Xavier, D., Chan, M. T. V., … Yusuf, S. (2014). Aspirin in patients undergoing noncardiac surgery. The New England Journal of Medicine, 370(16), 1494–1503. https://doi.org/10.1056/NEJMOA1401105
  • Forrest, J. B., Clemens, J. Q., Finamore, P., Leveillee, R., Lippert, M., Pisters, L., Touijer, K., & Whitmore, K. (2009). AUA best practice statement for the prevention of deep vein thrombosis in patients undergoing urologic surgery. The Journal of Urology, 181(3), 1170–1177. https://doi.org/10.1016/J.JURO.2008.12.027
  • Golemi, I., Salazar Adum, J. P., Tafur, A., & Caprini, J. (2019). Venous thromboembolism prophylaxis using the caprini score. Disease-a-Month : DM, 65(8), 249–298. https://doi.org/10.1016/J.DISAMONTH.2018.12.005
  • Irmak, B., Karadag, M., & Yildiz Emre, N. (2022). The risk factors for preoperative and postoperative deep vein thrombosis in surgical patients. Clinical and Experimental Health Sciences, 12, 120–127. https://doi.org/10.33808/clinexphealthsci.839430
  • Kakkos, S., Kirkilesis, G., Caprini, J. A., Geroulakos, G., Nicolaides, A., Stansby, G., & Reddy, D. J. (2022). Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism. The Cochrane Database of Systematic Reviews, 1(1). https://doi.org/10.1002/14651858.CD005258.PUB4
  • Mossanen, M., Krasnow, R. E., Zlatev, D. V., Tan, W. S., Preston, M. A., Trinh, Q. D., Kibel, A. S., Sonpavde, G., Schrag, D., Chung, B. I., & Chang, S. L. (2019). Examining the relationship between complications and perioperative mortality following radical cystectomy: a population-based analysis. BJU International, 124(1), 40–46. https://doi.org/10.1111/BJU.14636
  • Naik, R., Mandal, I., Hampson, A., Lane, T., Adshead, J., Rai, B. P., & Vasdev, N. (2019). The role of extended venous thromboembolism prophylaxis for major urological cancer operations. BJU International, 124(6), 935–944. https://doi.org/10.1111/BJU.14906
  • Nam, J. H., Kim, D. H., Yoo, J. H., Hwang, J. H., & Chang, J. D. (2017). Does preoperative mechanical prophylaxis have additional effectiveness in preventing postoperative venous thromboembolism in elderly patients with hip fracture?-Retrospective case-control study. PloS One, 12(11). https://doi.org/10.1371/JOURNAL.PONE.0187337
  • Oh, H., Boo, S., & Lee, J. A. (2017). Clinical nurses’ knowledge and practice of venous thromboembolism risk assessment and prevention in South Korea: a cross-sectional survey. Journal of Clinical Nursing, 26(3–4), 427–435. https://doi.org/10.1111/JOCN.13424
  • Pastori, D., Cormaci, V. M., Marucci, S., Franchino, G., Del Sole, F., Capozza, A., Fallarino, A., Corso, C., Valeriani, E., Menichelli, D., & Pignatelli, P. (2023). A Comprehensive Review of Risk Factors for Venous Thromboembolism: From Epidemiology to Pathophysiology. International Journal of Molecular Sciences, 24(4). https://doi.org/10.3390/IJMS24043169
  • Rausa, E., Kelly, M. E., Asti, E., Aiolfi, A., Bonitta, G., Winter, D. C., & Bonavina, L. (2018). Extended versus conventional thromboprophylaxis after major abdominal and pelvic surgery: systematic review and meta-analysis of randomized clinical trials. Surgery, 164(6), 1234–1240. https://doi.org/10.1016/J.SURG.2018.05.028
  • Reinke, C. E., Drebin, J. A., Kreider, S., Kean, C., Resnick, A., Raper, S., & Kelz, R. R. (2012). Timing of preoperative pharmacoprophylaxis for pancreatic surgery patients: a venous thromboembolism reduction initiative. Annals of Surgical Oncology, 19(1), 19–25. https://doi.org/10.1245/S10434-011-1858-1/TABLES/4
  • Rice, K. R., Brassell, S. A., & McLeod, D. G. (2010). Venous thromboembolism in urologic surgery: prophylaxis, diagnosis, and treatment. Reviews in Urology, 12(2–3), e111. https://doi.org/10.3909/riu0472
  • Sertkaya, Z. & Öztürk, M. (2014). Ürolojik Cerrahilerde Venöz Tromboembolizm. Endouroloji Bulteni, 135-138. https://doi.org/10.530/endo2014070307
  • Shakiba, B., Faegh, A., Emami, S., Heidari, K., & Maghsoudi, R. (2024). Procedure-Specific Thromboprophylaxis in urological surgeries: a narrative review. Urology Journal. https://doi.org/10.22037/UJ.V20I.8068
  • Speth, J. (2023). Guidelines in practice: prevention of venous thromboembolism. AORN Journal, 118(5), 321–328. https://doi.org/10.1002/AORN.14019
  • Sweetland, S., Green, J., Liu, B., De González, A. B., Canonico, M., Reeves, G., & Beral, V. (2009). Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. British Medical Journal (Clinical Research Ed.), 339(7736), 32. https://doi.org/10.1136/BMJ.B4583
  • Tikkinen, K. A. O., Agarwal, A., Craigie, S., Cartwright, R., Gould, M. K., Haukka, J., Naspro, R., Novara, G., Sandset, P. M., Siemieniuk, R. A., Violette, P. D., & Guyatt, G. H. (2014). Systematic reviews of observational studies of risk of thrombosis and bleeding in urological surgery (ROTBUS): introduction and methodology. Systematic Reviews, 3(1). https://doi.org/10.1186/2046-4053-3-150
  • Tikkinen, K. A. O., Cartwright, R., Gould, M. K., Naspro, R., Novara, G., Sandset, P. M., Violette, P. D., & Guyatt, G. H. (2022). EAU guidelines on thromboprophylaxis in urological surgery. https://uroweb.org/eau-guidelines/discontinued-topics/thromboprophylaxis
  • Tikkinen, K. A. O., Craigie, S., Agarwal, A., Siemieniuk, R. A. C., Cartwright, R., Violette, P. D., Novara, G., Naspro, R., Agbassi, C., Ali, B., Imam, M., Ismaila, N., Kam, D., Gould, M. K., Sandset, P. M., & Guyatt, G. H. (2018). Procedure-specific risks of thrombosis and bleeding in urological non-cancer surgery: systematic review and meta-analysis. European Urology, 73(2), 236–241. https://doi.org/10.1016/J.EURURO.2017.02.025
  • Tikkinen, K. A. O., Craigie, S., Agarwal, A., Violette, P. D., Novara, G., Cartwright, R., Naspro, R., Siemieniuk, R. A. C., Ali, B., Eryuzlu, L., Geraci, J., Winkup, J., Yoo, D., Gould, M. K., Sandset, P. M., & Guyatt, G. H. (2018). Procedure-specific risks of thrombosis and bleeding in urological cancer surgery: systematic review and meta-analysis. European Urology, 73(2), 242–251. https://doi.org/10.1016/J.EURURO.2017.03.008
  • Violette, P. D., Cartwright, R., Briel, M., Tikkinen, K. A. O., & Guyatt, G. H. (2016). Guideline of guidelines: thromboprophylaxis for urological surgery. BJU International, 118(3), 351–358. https://doi.org/10.1111/BJU.13496
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi (Diğer)
Bölüm Makaleler
Yazarlar

Pınar Ongün 0000-0003-2935-7583

Sakir Ongun 0000-0002-8253-4086

Yayımlanma Tarihi 25 Aralık 2024
Gönderilme Tarihi 15 Nisan 2024
Kabul Tarihi 11 Haziran 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 13 Sayı: 3

Kaynak Göster

APA Ongün, P., & Ongun, S. (2024). Evaluation of the Effectiveness of Venous Thromboembolism Prophylaxis in Patients Undergoing Major Urological Surgery. Balıkesir Sağlık Bilimleri Dergisi, 13(3), 490-496. https://doi.org/10.53424/balikesirsbd.1468790

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