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Chemical components, antidiabetic and anticancer effects of Origanum species

Cilt: 6 Sayı: 1 30 Nisan 2025
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Chemical components, antidiabetic and anticancer effects of Origanum species

Öz

Cancer and diabetes are two of the most common chronic diseases in people worldwide. Developing countries in particular, still rely on herbs as supportive or complementary therapies in the treatment of these diseases. The aim of this study is to review the phytochemical content and studies on the antidiabetic and anticancer effects of Origanum genus, which is safely used as spice and tea and is one of the important genera for Türkiye, and to reveal the importance of this species in terms of health. For this purpose, important databases such as ScienceDirect, Springer, Web of Science, Wiley Online Library, Taylor & Francis, Google Scholar were searched. As a result of these researches, it was seen that intensive researches were carried out especially on the essential oils of Origanum species and when the essential oil was evaluated phytochemically, it was seen that it contains especially carvacrol and thymol compounds as the main components. In addition, it was revealed that both the essential oil and extracts of this species have significant antidiabetic and anticancer effects when used both directly and in nanoparticles. Origanum species, which people are quite familiar with due to its safe use as a spice and tea by the public for many years, has shown that it can be promisingly effective on human health, including diabetes and cancer, with recent studies on it.

Anahtar Kelimeler

Origanum species, phytochemicals, antidiabetic activity, anticancer activity

Kaynakça

  1. Abdelmagid, A. D., & Said, A. M. (2024). Evaluation of the antidiabetic and hepatoprotective effect of Origanum majorana leaf extract and its nanoparticles in streptozotocin-induced diabetes in rats. Benha Veterinary Medical Journal, 46(2), 23-27.
  2. Aghajanyan, A., & Tadevosyan, A. (2022). Hypoglycemic activity of Origanum vulgare L. aqueous extract in hyperglycemia induced by immobilization stress in rabbits. Chemistry and Biology, 56(2), 141-150.
  3. Al Kamaly, O., Drioiche, A., Remok, F., Saidi, S., El Imache, A., El Makhoukhi, F., ... & Zair, T. (2024). Identification of compounds from Origanum compactum and Origanum elongatum using HPLC/UV-ESI-MS and comparative analysis of their antioxidant, antimicrobial, anticoagulant, and antidiabetic properties. Saudi Pharmaceutical Journal, 32(11), 102184.
  4. American Diabetes Association Professional Practice Committee. (2024). 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024. Diabetes care, 47(Supplement_1), S20-S42.
  5. Assaggaf, H., El Hachlafi, N., El fadili, M., Elbouzidi, A., Ouassou, H., Jeddi, M., ... & Mrabti, H. N. (2023). GC/MS profiling, in vitro antidiabetic efficacy of Origanum compactum Benth. essential oil and in silico molecular docking of its major bioactive compounds. Catalysts, 13(11), 1429.
  6. Aydemir, O., Polat, E. B., Aljesri, K., Taskin, T., Bitis, L., & Elcioglu, H. K. (2022). The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats. Journal of research in pharmacy, 26(6), 26.
  7. Bahmani, M., Zargaran, A., Rafieian-Kopaei, M., & Saki, K. (2014). Ethnobotanical study of medicinal plants used in the management of diabetes mellitus in the Urmia, Northwest Iran. Asian Pacific journal of tropical medicine, 7, S348-S354.
  8. Bozyel, M., Merdamert Bozyel, E., Canli, K., & Altuner, E. (2019). Anticancer uses of medicinal plants in Turkish traditional medicine. KSU Tarım ve Doğa Dergisi-KSU Journal of Agriculture and Nature, 22.
  9. Cakar, A., Aydemir, O., Kiyak-Kirmaci, H., Polat, E. B., Taskin, T., Kabasakal, L., & Elcioglu, H. K. (2023). Origanum majorana L. extract effects on kidney tissue in STZ-induced DM rats. Journal of Research in Pharmacy, 27(4).
  10. Chishti, S., Kaloo, Z. A., & Sultan, P. (2013). Medicinal importance of genus Origanum: A review. J. Pharmacogn. Phytother, 5(10), 170-177.

Kaynak Göster

APA
Bay, M. N., Şen, A., & Bitiş, L. (2025). Chemical components, antidiabetic and anticancer effects of Origanum species. Journal of Integrative and Anatolian Medicine, 6(1), 17-28. https://doi.org/10.53445/batd.1618550
AMA
1.Bay MN, Şen A, Bitiş L. Chemical components, antidiabetic and anticancer effects of Origanum species. J. Integr. Anatol. Med. 2025;6(1):17-28. doi:10.53445/batd.1618550
Chicago
Bay, Merve Nur, Ali Şen, ve Leyla Bitiş. 2025. “Chemical components, antidiabetic and anticancer effects of Origanum species”. Journal of Integrative and Anatolian Medicine 6 (1): 17-28. https://doi.org/10.53445/batd.1618550.
EndNote
Bay MN, Şen A, Bitiş L (01 Nisan 2025) Chemical components, antidiabetic and anticancer effects of Origanum species. Journal of Integrative and Anatolian Medicine 6 1 17–28.
IEEE
[1]M. N. Bay, A. Şen, ve L. Bitiş, “Chemical components, antidiabetic and anticancer effects of Origanum species”, J. Integr. Anatol. Med., c. 6, sy 1, ss. 17–28, Nis. 2025, doi: 10.53445/batd.1618550.
ISNAD
Bay, Merve Nur - Şen, Ali - Bitiş, Leyla. “Chemical components, antidiabetic and anticancer effects of Origanum species”. Journal of Integrative and Anatolian Medicine 6/1 (01 Nisan 2025): 17-28. https://doi.org/10.53445/batd.1618550.
JAMA
1.Bay MN, Şen A, Bitiş L. Chemical components, antidiabetic and anticancer effects of Origanum species. J. Integr. Anatol. Med. 2025;6:17–28.
MLA
Bay, Merve Nur, vd. “Chemical components, antidiabetic and anticancer effects of Origanum species”. Journal of Integrative and Anatolian Medicine, c. 6, sy 1, Nisan 2025, ss. 17-28, doi:10.53445/batd.1618550.
Vancouver
1.Merve Nur Bay, Ali Şen, Leyla Bitiş. Chemical components, antidiabetic and anticancer effects of Origanum species. J. Integr. Anatol. Med. 01 Nisan 2025;6(1):17-28. doi:10.53445/batd.1618550