Bovine Herpesvirus-1 (BHV-1) ve Subtipleri

Öz

Sığırların Herpesvirus (BHV-1) enfeksiyonları, sığırlarda üst solunum yolu (Infectious Bovine Rhinotracheitis-IBR) ve genital kanal enfeksiyonu (Infectitious Pustuler Vulvovaginitis-IPV, Infectitious Pustuler Balanoposthitis-IPB)’na sebep olan bulaşıcı latent seyirli viral bir enfeksiyondur. BHV-1, sığırların yanısıra koyun, keçi gibi hayvan türlerinde ateş, solunum sayısının artması, öksürük, burun akıntısı (önce seröz daha sonra mukopurulent), burun mukozasında hiperemi, bazen konjuktivitis, salya artışı, anoreksi, süt veriminde azalma gibi klinik bulgulara yol açabilen dünya çapında oldukça yaygın bir patojendir. Ülkemizde geçmiş yıllarda yapılan virolojik ve serolojk çalışmalarda bu virusun yaygınlığı belirlenmiştir. Ancak virusun moleküler karakterizasyonu ve subtiplendirilmesi ile ilgili çok az çalışma bulunmaktadır. Bu derlemede BHV-1 ve subtiplendirilmesi hakkında detaylı bilgiler sunulmuştur.

Anahtar Kelimeler

• Bovine Herpesvirus
• sığır
• subtiplendirme
• latent enfeksiyon

Bovine Herpesvirus-1 (BHV-1) and Subtypes

Öz

Bovine Herpesvirus (BHV-1) is a latent viral infection that causes upper respiratory tract (Infectious Bovine Rhinotracheitis-IBR) and genital canal infection (Infectious Pustuler Vulvovaginitis-IPV, Infectious Pustuler Balanoposthitis-IPB) in cattle. BHV may cause clinical symptoms such as fever, increased respiratory rate, cough, runny nose (first serous then mucopurulent), hyperemia in nasal mucosa, sometimes conjunctivitis, increased saliva, anorexia, decreased milk yield in cattle, as well as sheep and goats, it is a common pathogen worldwide. The prevalence of this virus has been determined in virological and serological studies in our country in the past years. However, there are very few studies on molecular characterization and subtyping of the virus. In this review, detailed information about BHV-1 and its subtyping is presented.

Anahtar Kelimeler

• Bovine Herpesvirus
• cattle
• subtyping
• latent infection

Kaynakça

1. Ackermann, M., Engels, M. (2006). Pro and contra IBR-eradication. Veterinary Microbiology, 113(3-4), 293-302. DOI: 10.1016/j.vetmic.2005.11.043.
2. Åkerstedt, J., Tarpai, A., Mørk, T. (2001). The surveillance and control programme for infectious bovine rhinotracheitis (IBR) and infectious pustular vulvovaginitis (IPV) in Norway. Annual Reports, Surveillance and Control Programmes for Terrestrial and Aquatic Animals in Norway, 95-107.
3. Albayrak, H., Özan, E., Beyhan, Y. E., Kurt, M., Kılıçoğlu, Y. (2012). A serological investigation of some aetiological agents associated with abortion in domestic water buffalo (Bubalus bubalis Linneaus, 1758) in Samsun province of Northern Turkey. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 7(3), 155-160.
4. Alpay, G., Tuncer, P., Yeşilbağ, K. (2014). Serological distribution of some viral infections in cattle, sheep and goats in an isolated island ecosystem. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 61: 43-48.
5. Aslan, M. E., Azkur, A. K., Gazyağcı, S. (2015). Epidemiology and genetic characterization of BVDV, BHV-1, BHV-4, BHV-5 and Brucella spp. infections in cattle in Turkey. The Journal of Veterinary Medical Science, 1-25. DOI: 10.1292/jvms.14-0657.
6. Ata, A., Kocamüftüoğlu, M., Hasırcıoğlu, S., Kale, M., Gülay, M. Ş. (2012). Investigation of relationship between Bovine Herpesvirus-1 (BHV-1) infection and fertility in repeat breeding dairy cows in family-type small dairy farms. Kafkas Universitesi Veteriner Fakültesi, 18(4), 579-583.
7. Ataseven, V. S., Başaran, Z., Yılmaz, V., Dağalp, S. B. (2010). Van bölgesi keçilerinde Parainfluenza Virus-3 (PIV-3) ve Bovine Herpesvirus-1 (BHV-1) enfeksiyonlarının seroprevalansı. Yüzüncü Yıl Üniversitesi Veteriner Fakultesi Dergisi, 21(1), 7-9.
8. Avcı, O., Yavru, S. (2013). Investigation of Bovine Herpesvirus-1, Bovine Viral Diarrhea Virus and Bovine Herpesvirus-4 in a dairy herd with naturally infected in Konya. Eurasian Journal of Veterinary Science, 29(2), 82-86.

9. Babiuk, L. A., Littel, S. D.- Hurk D. V., Tikoo, S. K. (1996). Immunology o bovine herpesvirus 1 infection. Veterinary Microbiology, 53(1-2), 31-42.
10. Baranowski, E., Keil, G., Lyaku, J., Rijsewijk, F. A., Jan, T. V. O., Pastoret, P. P., Thiry, E. (1996). Structural and functional analysis of bovine herpesvirus 1 minor glycoproteins. Veterinary Microbiology, 53(1-2), 91-101.
11. Belak, S., Ballagi-Pordany, A. (1993). Application of the polymerase chain reaction (PCR) in veterinary diagnostic virology. Veterinary Research Communications, 17: 55-72.
12. Boelaert, F., Speybroeck, N., Kruif, D. A., Aerts, M., Burzykowski, T., Molenberghs, G., Berkvens, D. L. (2005). Risk factors for bovine herpesvirus-1 seropositivity. Preventive Veterinary Medicine, 69(3-4), 285-295.
13. Burgu, İ., Dağalp, S. B. (1999). IBR-IPV virus enfeksiyonunun kontrol ve eradikasyonu. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 46: 263-267.
14. Campos, M., Ohmann, H. B., Hutchings, D., Rapin, N., Babiuk, L. A., Lawman, M. J. (1989). Role of interferon-gamma in inducing cytotoxicity of peripheral blood mononuclear leukocytes to bovine herpesvirus type 1 (BHV-1)-infected cells. Cellular Immunology, 120(1), 259-269.
15. Campos, M., Rossi, C. R. (1986). Cytotoxicity of bovine lymphocytes after treatment with lymphokines. American Journal of Veterinary Research, 47(7), 1524-1528.
16. Collins, J. K, Butcher A. C., Rıegel, C. A. (1985). Immune response to bovine herpesvirus type 1 infections: virus spesific antibodies in sera from infected animals. Journal of Clinical Microbiology, 21(4), 546-552.
17. d’Offay, J. M., Mock, R. E., Fulton, R. W. (1993). Isolation and characterization of encephalitic bovine herpesvirus type 1 isolates from cattle in North America. American Journal of Veterinary Research, 54(4), 534-539.
18. Dannacher, G., Perrin, M., Perrin, B. (1979). Use of a technique of passive haemagglutination for the detection of antibodies against the virus of infectious rhinotracheitis in cattle. Recueil de Medecine Veterinaire, 155: 633-637.
19. Delhon, G., Moraes, M. P., Lu, Z., Afonso, C. L., Flores, E. F., Weiblen, R., Kutish, G. F., Rock D. L. (2003). Genome of bovine herpesvirus 5. Journal of Virology, 77(19), 10339-10347. DOI: 10.1128/JVI.77.19.10339-10347.2003.
20. Devireddy, L. R., Jones, C. J. (1999). Activation of caspases and p53 by bovine herpesvirus 1 infection results in programmed cell death and efficient virus release. Journal of Virology, 73(5), 3778-3788. DOI: 10.1128/JVI.73.5.3778-3788.1999.
21. Duman, R., Yavru, S., Bulut, O., Avcı, O. (2013). Sığırlarda Bovine Herpesvirus-1 enfeksiyonlarının Enzyme-Linked Immunosorbent Assay ve Mikronötralizasyon Testi ile karşılaştırmalı tespiti. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 2: 129-136, Erzurum.
22. Edwards, S., Chasey, D., White, H. (1983). Experimental infectious bovine rhinotracheitis: Comparison of four antigen detection methods. Research of Veterinary Science, 34: 42-45.
23. Edwards, S., Newman, R. H., White, H. (1991). The virulence of British isolates of bovid herpesvirus 1 in relationship to viral genotype. British Veterinary Journal, 147(3), 216-231.
24. Edwards, S., White, H., Nixon, P. (1990). A study of the predominant genotypes of bovid herpesvirus 1found in the UK. Veterinary Microbiology, 22: 213-223.
25. Engels, M., Steck, F., Wyler, R. (1981). Comparison of the genomes of infectious bovine rhinotracheitis and infectious pustular vulvovaginitis virus strains by restriction endonuclease analysis. Archives of Virology, 67: 169-174.
26. Fenner, F., Bachman, P. A., Gibbs, E. P. J., Murphy, F. A., Studdert, M. J., White, D. O. (1987). Herpesviridae. Veterinary Virology. By Academic Press. Inc. Chapter 19, 339-373, London.
27. Fiume, G. C, Cocchi, F., Menotti, L, Lopez, M. (2000). The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells. Medical Virology, 10: 305-319.
28. Fraefel, C., Wirth, U. V., Vogt, B., Schwyzer, M. (1993). Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: the circ gene. Journal of Virology, 67(3), 1328-1333.
29. Frey, H. R., Lies, B. (1971). Vermehrungskinetik und Verwendbarkeit eines stark zytopatogenen VD-MD Virus stammes für diagnostische Untersuchungen mit der Mikrotitermethode. Zentbl. Veterinary Medicine, 18: 61-71.
30. Fulton, R. W., d’Offay, J. M., Eberle, R., Moeller, R. B., Campen, H. V., O’Toole, D., Chase, C., Miller, M. M., Sprowls, R., Nydam, D. V. (2015). Bovine herpesvirus-1: evaluation of genetic diversity of subtypes derived from field strains of varied clinical syndromes and their relationship to vaccine strains. Vaccine, 33(4), 549-58. DOI: 10.1016/j.vaccine.2014.11.033.
31. Fusco, G., Amoroso, M. G., Gesualdi, M. N., Viscardi, M. (2015). Development of a pyrosequencing assay for the typing of alphaherpesviruses. MethodsX, 2: 47-52. DOI: 10.1016/j.mex.2015.01.001.
32. Geiser, V., Zhang, Y., Jones, C. (2005). Analysis of a bovine herpesvirus 1 recombinant virus that does not express the bICP0 protein. Journal of General Virology, 86(7), 1987–1996. DOI: 10.1099/vir.0.80921-0.
33. Gerdts, V., Beyer, J., Lomniczi, B., Mettenleiter, T. C. (2000). Pseudorabies virus expressing bovine herpesvirus 1 glycoprotein B exhibits altered neurotropism and increased neurovirulence. Journal of Virology, 74(2), 817-827. DOI: 10.1128/JVI.74.2.817-827.2000.
34. Granzow, H., Klupp, B. G., Fuchs, W., Veits, J., Osterrieder, N., Mettenleiter T. C. (2001). Egress of alphaherpesviruses: Comparative ultrastructural study. Journal of Virology, 75(8), 3675-3684. DOI 10.1128/JVI.75.8.3675-3684.2001.
35. Gür, S., Acar, A., Gençay, A., Kale, M., Yılmaz, S. (2016). Ege Bölgesinde Infectious Bovine Rhinotracheitis virus enfeksiyonunun serolojik olarak araştırılması. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstütisi Dergisi, 4(1), 1-10.
36. Gür, S., Erol, N., Yapıcı, O., Kale, M., Tan, M. T., Turan, T., Çakmak, M. A., Tosun C., Yılmaz, S., Acar, A., Özenli, I., Gür, C. (2018). The role of goats as reservoir hosts for bovine herpes virus 1 under field conditions. Tropical Animal Health and Production, 51: 753-758. DOI: 10.1007/s11250-018-1746-9.
37. Hage, J. J., Schukken Y. H., Barkema, H. W., Benedictus, G., Rijsewijk, F. A., Wentink, G. H. (1996). Population dynamics of bovine herpesvirus 1 infection in a dairy herd. Veterinary Microbiology, 53: 169-180.
38. Hage, J. J., Vellema, P., Schukken, Y. H., Barkema, H. W., Rijsewijk F. A., Van O. J. T., Wentink, G. H. (1997). Sheep do not have a major role in bovine herpesvirus 1 transmission. Veterinary Microbiology, 57: 41-54.
39. Henderson, G., Perng G. C., Nesburn A. B., Wechsler S. L., Jones, C. (2004). The latency related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection. Journal of NeuroVirology, 10(1), 64-70.
40. Herring, A. J., Nettleton, P. F., Burrels, C. (1980). A micro-enzymelinked immunosorbent assay for the detection of antibodies to infectious bovine rhinotracheitis virus. Veterinary Research, 107: 155-156.
41. Hidayati, D. N., Untari, T., Wibowo, M. H., Akiyama, K., Asmara, W. (2018). Cloning and sequencing gB, gD, and gM genes to perform the genetic variability of bovine herpesvirus-1 from Indonesia. Veterinary World, 11(9), 1255-1261. DOI: 10.14202/vetworld.2018.1255-1261.
42. Hinkley, S., Ambagala, A. P., Jones, C. J., Srikumaran, S. (2000). A vhs-like activity of bovine herpesvirus-1. Archives Virology, 145: 2027-2046.
43. Hossain, A., Schang, L. M., Jones, C. (1995). Identification of gene products encoded by the latency-related gene of bovine herpesvirus 1. Journal of Virology, 69: 5345-5352.
44. Hou, P., Wang, H., Zhao, G., He, C., He, H. (2017). Rapid detection of infectious bovine Rhinotracheitis virus using recombinase polymerase amplification assays. Veterinary Research, 13: 386. 1-9. DOI: 10.1186/s12917-017-1284-0.
45. ICTV, (2019). Virus Taxonomy: 2019. Release. https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae Erişim Tarihi: 11.11.2020.
46. Inman, M., Zhou, J., Webb, H., Jones, C., (2004) Identification of a novel bovine herpesvirus 1 transcript containing a small open reading frame that is expressed in trigeminal ganglia of latently infected cattle. Journal of Virology, 78(10), 5438-5447. DOI: 10.1128/JVI.78.10.5438-5447.2004.
47. Jones, C. (1998). Alphaherpesvirus latency: its role in disease and survival of the virus in nature. Advances in Virus Research, 51: 47-99.
48. Jones, C., Geiser, V., Henderson, G., Jiang, Y., Meyer, F., Perez, S., Zhang ,Y. (2006). Functional analysis of bovine herpesvirus 1 (BHV-1) genes expressed during latency. Veterinary Microbiology, 113(3-4), 199-210. DOI: 10.1016/j.vetmic.2005.11.009.
49. Jones, C., Silva, L. F., Sinani, D. (2011). Regulation of the latency–reactivation cycle by products encoded by the bovine herpesvirus 1 (BHV-1) latency-related gene. Journal of NeuroVirology, 17: 535-545. DOI: 10.1007/s13365-011-0060-3.
50. Kaashoek, M. J., Straver, P. H., Van, R. E., Quak, J., Van, O. J. T. (1996). Virulence, immunogenicity and reactivation of seven bovine herpesvirus 1.1 strains: clinical and virological aspects. Veterinary Research., 139(17), 416-421. DOI: 10.1136/vr.139.17.416.
51. Kibenge, F. S. B., Harris, L. M., McKenna, P. K., Wadowska, D., Yason, C. V. (1994). Amplification of strains of bovine herpesvirus 1 by use of polymerase chain reaction with primers in the tymidine kinase region. American Journal of Veterinary Research, 55(9), 1206-1212.
52. Koppers-Lalic, D., Rijsewijk, F. A., Verschuren, S. B., van Gaans-Van den Brink J.A., Neisig, A., Ressing, M. E., Neefjes, J., Wiertz, E. J. (2001). The UL41-encoded virion host shuto (vhs) protein and vhs-independent mechanisms are responsible for down-regulation of MHC class I molecules by bovine herpesvirus 1. Journal of General Virology, 82(9), 2071-2081. DOI: 10.1099/0022-1317-82-9-2071.
53. Kupferschmied, H. U., Kihm, U., Bachmann, P., Müller, K. H., Ackermann, M. (1986). Transmission of IBR/IPV virus in bovine semen: A case report. Theriogenology, 25: 439-443.
54. Leuzinger, H., Ziegler, U., Schraner, E. M., Fraefel, C., Glauser, D. L., Heid I., Ackermann, M., Mueller, M., Wild, P. (2005). Herpes simplex virus 1 envelopment follows two diverse pathways. Journal of Virology, 79(20), 13047-13059. DOI: 10.1128/JVI.79.20.13047-13059.2005.
55. Liang, X., Pyne, C., Li, Y., Babiuk, L. A., Kowalski, J. (1995). Delineation of the essential function of bovine herpesvirus 1 gD: an indication for the modulatory role of gD in virus entry. Virology, 207(2), 429-441. DOI: 10.1006/viro.1995.1102.
56. Liu, T., Khanna, K. M., Chen, X., Fink, D .J., Hendricks, R. L. (2000). CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. Journal of Experimental Medicine, 191(9), 1459-1466. DOI: 10.1084/jem.191.9.1459.
57. Magalhães-Junior, M. J., Baracat-Pereira, M. C., Pereira, L. K. J., Vital, C. E., Santos, M. R., Cunha, P. S., Fernandes, K. M., Bressan, G. C., Fietto, J. L. R., Silva-Júnior, A., Almeida, M. R. (2020). Proteomic and phosphoproteomic analyses reveal several events involved in the early stages of bovine herpesvirus 1 infection. Archives of Virology, 165(1), 69-85. DOI: 10.1007/s00705-019-04452-1.
58. Mahajan, V., Banga, S., Deka, D., Filia, G., Gupta, A. (2013). Comparison of diagnostic tests for diagnosis of infectious bovine rhinotracheitis in natural cases of bovine abortion. Journal of Comparative Pathology, 149(4), 391-401. DOI: 10.1016/j.jcpa.2013.05.002.
59. Majumder, S, Pandey, A. B, Ramakrishnan, M. A. (2013). Genetic characterization of complete open reading frame of glycoprotein C gene of bovine herpesvirus 1. Veterinary World, 6: 897-900. DOI: 10.14202/vetworld.2013.897-900.
60. Malla, J. A., Chakravarti, S., Gupta, V., Chander, V., Sharma, G. K., Qureshi S., Mishra, A., Gupta, V. K., Nandi S. (2018). Novel Polymerase Spiral Reaction (PSR) for rapid visual detection of Bovine Herpesvirus 1 genomic DNA from aborted bovine fetus and semen. Gene, 644: 107-112. DOI: 10.1016/j.gene.2017.11.004.
61. Mars, M. H., de Jong, M. C., van Maanen, C., Hage, J. J., van Oirschot, J. T. (2000). Airborne transmission of bovine herpesvirus 1 infections in calves under field conditions. Veterinary Microbiology, 76(1), 1-13. DOI: 10.1016/S0378-1135(00)00218-2.
62. Mechor, G. D., Rousseaux, C. G., Radostits, O. M., Babiuk, L. A., Petrie, L. (1987). Protection of newborn calves against fatal multisystemic infectious bovine rhinotracheitis by feeding colostrum from vaccinated cows. Canadian Journal Veterinary Research, 51(4), 452-459.
63. Mettenleiter, T. C., Klupp, B. G., Granzow, H. (2006). Herpesvirus assembly: a tale of two membranes. Current Opinion in Microbiology, 9(4), 423-429. DOI: 10.1016/j.mib.2006.06.013.
64. Metzler, A. E., Matile, H., Gassmann, U., Engels, M., Wyler, R. (1985). European isolates of bovine herpesvirus 1: a comparison of restriction endonuclease sites, polypeptides, and reactivity with monoclonal antibodies. Archives of Virology, 85: 57-69.
65. Meyer, G., Hanon, E., Georlette, D., Pastoret, P. P., Thiry, E. (1998). Bovine herpesvirus type 1 glycoprotein H is essential for penetration and propagation in cell culture. Journal of General Virology, 79(8), 1983-1987. DOI: 10.1099/0022-1317-79-8-1983.
66. Meyer, G., Lemaire, M., Lyaku, J., Pastoret, P. P., Thiry, E. (1996). Establishment of a rabbit model for bovine herpesvirus type 5 neurological acute infection. Veterinary Microbiology, 51(1-2), 27-40. DOI: 10.1016/0378-1135(96)00016-8.
67. Miller, J. M., Maaten, V. D. (1986). Experimentally induced infectious bovine rhinotracheitis virus infection during early pregnancy: effect on the bovine corpus luteum and conceptus. American Journal of Veterinary Research, 47(2), 223-228.
68. Miller, J. M., Van der Maaten, M. J. (1984). Reproductive tract lesions in heifers after intrauterine inoculation with infectious bovine rhinotracheitis virus. American Journal Veterinary Research, 45(4), 790-794.
69. Miller, J. M., Whetstone, C. A., Van der Maaten, M. J. (1991a). Abortifacient property of bovine herpesvirus type 1 isolates that represent three subtypes determined byrestriction endonuclease analysis of viral DNA. American Journal Veterinary Research, 52: 458-461.
70. Miller, J. M., Whetstone, C. A., Bello, L. J., Lawrence, W. C. (1991b). Determination of abilityof a thymidine kinase-negative deletion mutant of bovine herpesvirus-1 to cause abortion in cattle. American Journal Veterinary Research, 52: 1038-1043.
71. Misra, V., Bratanich, A. C., Carpenter, D., O’Hare P. (1994). Protein and DNA elements involved in transactivation of the promoter of the bovine herpesvirus (BHV) 1 IE-1 transcription unit by the BHV alpha gene transinducing factor. Journal of Virology, 68(8), 4898– 4909.
72. Muthannan, A. R., Chetan, Y. P., Arfa, F., Chandrasekar, S., Mageswary, R, Deenanath, A., Rukhsana, B., Dhanavelu, M., Sukdeb, N., Gupta, V. K. (2018). Differentiation of bovine herpesvirus1 subtypes based on UL0.5 gene sequencing. Indian Virological Society, 29(1), 106-108. DOI: 10.1007/s13337-018-0422-z.
73. Muylkens, B, Thiry, J, Kirten, P, Schynts, F, Thiry, E. (2007). Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis. Veterinary Research, 38(2), 181-209. DOI: 10.1051/vetres:2006059.
74. Nandi, S., Kumar, M., Manohar, M., Chauhan, R. S. (2009). Bovine Herpes virus infections in cattle. Animal Health Research, 10(1): 85-98. DOI: 10.1017/S1466252309990028.
75. Noordegraaf, V. A., Labrovic, A., Frankena, K., Pfeifer, D. U., Nielen, M. (2004). Simulated hazards of loosing infection-free status in a Dutch BHV1 model. Preventive Veterinary Medicine, 62(1), 51–58. DOI: 10.1016/j.prevetmed.2003.09.001.
76. Nuotio, L., Neuvonen, E., Hyytiäinen, M. (2007). Epidemiology and eradication of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV) virus in Finland. Acta Veterinaria Scandinavica, 49(3), 1-6. DOI: 10.1186/1751-0147-49-3.
77. Nylin, B., Strøger, U., Rønsholt, L. (2000). A retrospective evaluation of a bovine herpesvirus-1 (BHV-1) antibody ELISA on bulk-tank milk samples for classification of the BHV-1 status of Danish dairy herds. Preventive Veterinary Medicine, 47(1-2), 91-105. DOI: 0.1016/S0167-5877(00)00163-X.
78. OIE Terresmanuel, (2018). Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2019. Chapter 3.4.11. https://www.oie.int/standard-setting/terrestrial-manual/access-online/Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (NB: Version adopted in May 2017)
79. Oreshkova, S. F., Glotov, A. G., Spermaıkhın, V. I., Mınenkova, O. O., Puzyrev, A. T., Tıkunova, N. V., Baturna II, Peterenko, V. A., IL’ıchev, A. A. (1995). Detection of bovine infectious rhinotracheitis virus by hybridization using nonradioactive DNA-ptobes. Vopr Virusol, 40(6), 279-282.
80. Owen, N. V., Chow, T. L., Molello, J. A. (1964). Bovine fetal lesions experimentally produced by infectious bovine rhinotracheitis virus. American Journal of Veterinary Research, 25: 1617-1626.
81. Özgünlük, İ., Yıldırım, Y. (2017). Güneydoğu Anadolu Bölgesi’ndeki sığırlarda Bovine Herpes Virus 1 (BHV 1) ve Bovine Viral Diarrhea Virus (BVDV) enfeksiyonlarının serolojik olarak araştırılması. Harran Üniviversitesi Veteriner Fakültesi Dergisi, 6(2), 152-157. DOI: 10.31196/huvfd.390122.
82. Ramakrishnan, M. A., Pundkar, C. Y., Fayaz A, Sekar, S. C., Mageswary, W., Ashokkumar, D., Bano, R., Muthuchelvan, D., Nandi, S., Gupta, V. K. (2018). Diferentiation of bovine herpesvirus1 subtypes based on UL0.5 gene sequencing. Virus Disase, 29(1), 106-108. DOI: 10.1007/s13337-018-0422-z.
83. Raza, S., Shahin, F., Zhai, W., Li, H., Alvisi, G., Yang, K., Chen, X., Chen, Y., Chen J., Hu, C. J. M. (2020). Ivermectin inhibits Bovine Herpesvirus 1 DNA polymerase nuclear ımport and ınterferes with viral replication. Microorganisms, 8(3), 409. DOI: 10.3390/microorganisms8030409.
84. Rijsewijk, F. A., Kaashoek M. J., Langeveld J. P., Meloen R., Judek J., Bienkowska, S. K., Maris-Veldhuis, M. A., van Oirschot, J. T. (1999). Epitopes on glycoprotein C of bovine herpesvirus-1 (BHV-1) that allow differentiation between BHV-1.1 and BHV-1.2 strains. Journal of General Virology, 80(6): 1477-1483. DOI: 10.1099/0022-1317-80-6-1477.
85. Schröder R. J., Moys, M. D. (1954). An acut respiratory infection of dairy cattle. Journal of American Veterinary Medical Association, 125: 471-472.
86. Schröder, C., Keil, G. M. (1999). Bovineherpesvirus 1 requires glycoprotein H for infectivity and direct spreading and glycoproteins gH(W450) and gB for glycoprotein D independent cell to cell spread. Journal of General Virology, 80(1), 57-61. DOI: 10.1099/0022-1317-80-1-57.
87. Schröder, C., Linde, G., Fehler, F., Keil, G. M. (1997). From essential to beneficial: glycoprotein D loses importance for replication of bovine herpesvirus 1 in cell culture. Journal of Virology, 71(1), 25-33.
88. Schwyzer, M. Wirth, U. V., Vogt, B., Fraefel, C. (1994). bICP22 of bovine herpesvirus 1 is encoded by a spliced 1.7 kb RNA which exhibits immediateearly and late transcription kinetics. Journal of General Virology, 75(7), 1703–1711. DOI: 10.1099/0022-1317-75-7-1703.
89. Silim, A., Elazhary, M. A. S. Y. (1983). Detection of infectious bovine rhinotracteitis and bovine viral diarrhea in the nasal epithelial cells by the direct immunofluorescence technique. Canadian Journal Of Comparative Medicine, 47(1), 18–22.
90. Smith, G. A., Young, P. L., Reed, K. C. (1995). Emergence of a new bovine herpesvirus 1 strain in Australian feedlots. Archives of Virology, 140: 599-603.
91. Solis-Calderon, J. J., Segura-Correa, V. M., Segura-Correa, J. C., Alvarado-Islas, A. (2003). Seroprevalence of and risk factors for infectious bovine rhinotracheitis in beef cattle herds of Yucatan, Mexico. Preventive Veterinary Medicine, 57(4), 199-208. DOI: 10.1016/S0167-5877(02)00230-1.
92. Spilki, F. R., Esteves, P. A., de Lima, M., Franco, A. C., Chiminazzo, C., Flores, E. F., Weiblen, R., Driemeier, D., Roehe, P. M. (2004). Comparative pathogenicity of bovine herpesvirus 1 (BHV-1) subtypes 1 (BHV-1.1) and 2a (BHV-1.2a). Pesquisa Veterinaria Brasileira, 24(1), 43-49. DOI: 10.1590/S0100-736X2004000100010.
93. Straub, O. C., Wettke, K., Weiland, F. (1982). Seuchenhaftes Aufreten von IBR-IPV Virus Aborten. Tierarztl Umschau, 37: 613-617.
94. Thiry, J., Keuser, V., Muylkens, B., Meurens, F., Gogev, S., Vanderplasschen, A., Thiry, E. (2006). Ruminant alphaherpesviruses related to bovine herpesvirus 1. Veterinary Research, 37(2), 169-19. DOI: 10.1051/vetres:2005052.
95. Trepanier, P., Seguin, C., Bastien, Y., Boulay G., Lussier, G., Trudel, M. (1985). Hemagglutinating activity associated with bovine herpesvirus type 1. Veterinary Microbiology, 10(6), 517-523. DOI: 10.1016/0378-1135(85)90060-4.
96. van Schaik, G. (2001). Risk and economics of disease introduction to dairy farms. Tijdschr. Diergeneeskd, 126(12), 414-418.
97. van Schaik, G., Schukken, Y. H., Nielen, M., Dijkhuizen, A. A., Barkema, H. W., Benedictus, G. (2002). Probability of and risk factors for introduction of infectious diseases into Dutch SPF dairy farms: a cohort study. Preventive Veterinary Medicine, 54(3), 279-289. DOI: 10.1016/S0167-5877(02)00004-1.
98. Vilcek, S. (1993). Detection of bovine herpesvirus 1 (BHV-1) genome by PCR. Journal of Virological Methods, 41(2), 245-248. DOI: 10.1016/0166-0934(93)90132-B.
99. Wang, P., Hurley, D. J., Braun, L. J., Chase, C. C. L. (2001). Detection of bovine herpesvirus-1 in peripheral blood mononuclear cells eight months postinfection. Journal of Veterinary Diagnostic Investigation 13: 424-427. DOI: 10.1177/104063870101300512.
100. Wellenberg, G. J., Verstraten, E., Mars, M. H., Van Oischot, J. T. (1998). Detection of bovine herpesvirus1 glycoprotein E antibodies inindividual milk samples by enzyme-linked immunosorbent assays. Journal of Clinical Microbiology, 36(2), 409-413. DOI: 10.1128/JCM.36.2.409-413.1998.
101. Whetsone, C. A., Miller, J. M. (1989). Two different strains of an alphaherpesvirus can establish latency in the same tissue of the host animal: evidence from bovine herpesvirus 1. Archives of Virology, 107: 27-34.
102. Winkler, M. T., Doster, A., Jones, C. (2000). Persistence and reactivation of bovine herpesvirus 1 in the tonsils of latently infected calves. Journal of Virology, 74(11), 5337-5346. DOI: 10.1128/JVI.74.11.5337-5346.2000.
103. Wirth, U. V., Vogt, B., Schwyzer, M. (1991). The three major immediate-early transcripts of bovine herpesvirus 1 arise from two divergent and spliced transcription units. Journal of Virology, 65(1), 195-205.
104. Wirth, U. V., Gunkel, K., Engels, M., Schwyzer, M. (1989). Spatial and temporal distribution of bovine herpesvirus 1 transcripts. Journal of Virology, 63(11), 4882-4889.
105. Wudunn, D, Spear, P. G. (1989). Initial interaction of Herpes Simplex Virus with cells is binding to Heparan Sulfate. Journal of Virology, 63(1), 52-58.
106. Wyler, R., Engels, M., Schwyzer, M. (1989). Infectious bovine rhinotracheitis/vulvovaginitis (BHV1). In: Herpesvirus Diseases of Cattle, Horses and Pigs. (G. Wittmann, Ed.). Kluwer Academic Publishers, 1-72, Boston.
107. Xia, J. Q., Yason, C. V., Kibenge, F. S. (1995). Comparison of dot blot hybridization, polymerase chain reaction, and virus isolation for detection of Bovine Herpesvirus tip-1 (BHV-1) in artificially infected bovine sperma. Canadian Journal Of Veterinary Research, 59(2), 102-109.
108. Yavru, S., Avcı, O., Kale, M. (2014). Serologic and virologic investigation of BHV-1, BVDV and BHV-4 in cattle with metritis. Animal Veterinary Science, 2(5), 142-145.
109. Yavru, S., Öztürk, F., Şimşek, A., Yapkıç, O., Yıldız, C. (1998). Suni ve tabii tohumlamada kullanılan boğaların spermalarından virus izolasyonu. Veteriner Bilimleri Dergisi, 14(2), 39-46.
110. Yıldırım, Y., Yılmaz, V., Kalaycıoğlu, A. T., Dağalp, S. B., Majarashın, A. R. F., Çelebi, Ö., Akça, D. (2011). An investigation of a possible involvement of BVDV, BHV-1 and BHV-4 infections in abortion of dairy cattle in Kars District of Turkey. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 17(6), 879-883. DOI: 10.9775/kvfd.2011.623.
111. Yılmaz, V., Çoşkun, N. (2016). Investigation of Bovine Herpes Virus Type 1 infection in sheep in the Kars Province of Turkey. Harran Üniversitesi Veteriner Fakültesi Dergisi, 5(1), 40-43.