Some Bioactive Properties of Honey

Yıl 2022, Cilt: 2 Sayı: 1, 40 - 49, 30.06.2022

Büşra Beltekin Nurullah Demir

Öz

Bal, içerdiği vitaminler, mineraller, organik asitler, flavonoidler, fenolik asitler, aminoasitler ve
enzimler nedeniyle sindirimi kolay, besleyici ve pek çok hastalığa karşı koruyucu ve tedavi edici
özellik gösteren fonksiyonel bir gıdadır. Antik çağlardan günümüze kadar medikal amaçlarla
kullanımı devam etmektir. İçeriğindeki aktif bileşenler sayesinde antioksidan, anti-kanser,
antimikrobiyal, dermatolojik, antiinflamatuar ve prebiyotik etkiye sahiptir. Güçlü antimikrobiyal
özelliği nedeniyle balın koronavirüs (COVID-19) septomlarını azaltmadaki etkinliğini içeren
klinik çalışmalar da devam etmektedir. Bu derleme, balın antioksidan, antikanser,
antimikrobiyal ve anti- COVID-19 özelliklerini vurgulamayı amaçlamıştır.

Anahtar Kelimeler

Honey , Bioactive Compounds , Apitherapy , Functional Food

Kaynakça

• [1] Bölüktepe FE, Yılmaz S (2008) Arı ürünlerinin bilinirliği ve satın alınma sıklığı. U Bee J, 8(2), 53-62.
• [2] Alimentarius C (2001) Revised codex standard for honey, standards and standard methods. Codex Alimentarius Commission FAO/OMS, 11, 1–7.
• [3] Pita-Calvo C, V´azquez M (2017) Differences between honeydew and blossom honeys: A review. Trends in Food Science & Technology, 59, 79–87.
• [4] Avila S, Beux MR, Ribani RH, Zambiazi RC (2018) Stingless bee honey: Quality parameters, bioactive compounds, health-promotion properties and modification detection strategies. Trends in Food Science & Technology, 81(March), 37–50.
• [5] Seraglio SKT, Silva B, Bergamo G, Brugnerotto P, Gonzaga LV et al. (2019) An overview of physicochemical characteristics and healthpromoting properties of honeydew honey. Food Research International, 119, 44–66.
• [6] Khan RU, Naz S, Abudabos AM (2017) Towards a better understanding of the therapeutic applications and corresponding mechanisms of action of honey. Environ. Sci. Pollut. Res. 24, 27755–27766. https://doi.org/10.1007/s11356-017-0567-0.
• [7] Eteraf-Oskouei T, Najafi M (2013) Traditional and modern uses of natural honey in human diseases: a review. Iran. J. Basic Med. Sci. 16, 731–742.
• [8] Lazarevic KB, Jovetic MS, Tesic ZL (2017) Physicochemical parameters as a tool for the assessment of origin of honey. J. AOAC Int. 100, 840–851.
• [9] Mutlu C, Erbaş M, Arslan Tontul S (2017) Bal ve Diğer Arı Ürünlerinin Bazı Özellikleri ve İnsan Sağlığı Üzerine Etkileri. Akademik Gıda. 15(1), 75-83.
• [10] Zulkhairi Amin FA, Sabri S, Mohammad SM, Ismail M, Chan KW et al. (2018) Therapeutic properties of stingless bee honey in comparison with european bee honey. Adv. Pharmacol. Sci., 6179596. https://doi.org/10.1155/2018/6179596.
• [11] Karabagias IK, Badeka AV, Kontakos S, Karabournioti S, Kontominas MG (2014) Botanical discrimination of Greek unifloral honeys with physico-chemical and chemometric analyses. Food Chemistry. 165, 181-190.
• [12] Stephens J, Greenwood D, Fearnley L, Bong J, Schlothauer R et al. (2015) Honey production and compositional parameters. Processing and Impact on Active Components in Food, 675-680.
• [13] Khan SU, Anjum SI, Rahman K, Ansari MJ, Khan WU et al. (2018) Honey: single food stuff comprises many drugs. Saudi J. Biol. Sci. 25, 320–325. https://doi.org/10.1016/j.sjbs.2017.08.004.
• [14] Nombré I, Schweitzer P, Boussim JI, Rasolodimby JM (2010) Impacts of storage conditions on physicochemical characteristics of honey samples from Burkina Faso. African Journal of Food Science, 4(7), 458-463.
• [15] Bogdanov S, Lüllmann C, Martin P, von der Ohe W, Russmann H et al. (2015) Honey quality and international regulatory standards: review by the International Honey Commission. Bee World, 80(2).
• [16] Afroz R, Tanvir EM, Zheng W, Little PJ (2016) Molecular Pharmacology of Honey. Journal of Clinical & Experimental Pharmacology. 6(3).
• [17] Seraglio SKT, Bergamo G, Brugnerotto P, Gonzaga LV, Fett R et al. (2021) Aliphatic organic acids as promising authenticity markers of bracatinga honeydew honey. Food Chem. 343, 128449. https://doi.org/10.1016/j. foodchem.2020.128449.
• [18] Hossen MS, Ali MY, Jahurul MHA, Abdel-Daim MM, Gan SH et al. (2017) Beneficial roles of honey polyphenols against some human degenerative diseases: a review. Pharmacol. Rep. 69, 1194–1205. https://doi.org/10.1016/j.pharep.2017.07.002.
• [19] Pyrzynska K, Biesaga M (2009) Analysis of Phenolic Acids and Flavonoids in Honey. Trends in Analytical Chemistry, 28(7).
• [20] Samarghandian S, Azimi-Nezhad M, Shahri AMP, Farkhondeh T (2019) Antidotal or protective effects of honey and chrysin, its major polyphenols, against natural and chemical toxicities. Acta Biomed. 90, 541 558. https://doi.org/10.23750/abm.v90i4.7534.
• [21] Kalaycıoğlu L, Serpek B, Nizamlıoğlu M, Başpınar N, Tiftik MA (2006) Biyokimya. 3. Basım. Ankara: Nobel Yayın, s. 373.
• [22] Bogdanov S, Lullmann C, Martin P, Ohe WVD, Russmann H et al. (2000) Honey quality, methods of analysis and international r egulatory standards: Review of the work of the international honey commission, Swiss Bee Research Centre, FAM, Liebefeld, Switzerland.
• [23] Güler A, Bakan A, Nisbet C, Yavuz O (2007) Determination of important biochemical properties of honey to discriminate pure and adulterated honey with sucrose (Saccharum officinarum L.) syrup. Food Chem, 105, 1119–1125.
• [24] White JW (1994) The role of HMF and diastase assays in honey quality evaluation. Bee World, 75(3), 104-117.
• [25] Rios AM, Novoa ML, Vit P (2001) Effects of extraction, storage conditions and heating treatment on antibacterial activity of Zanthoxylum fagara honey from, Cojedes, Venezuela. Rev Cientifica, 11 (5), 397 402.
• [26] Karadal F, Yıldırım Y (2012) Balın Kalite Nitelikleri, Beslenme ve Sağlık Açısından Önemi. Erciyes Üniversitesi Veteriner Fakültesi Fakülte Dergisi, 9(3), 197-209.
• [27] Tosi E, Martinet R, Ortega M, Lucero H, R’e E(2008) Honey diastase activity modified by heating. Food Chem,106, 883–887.
• [28] Da Silva PM, Gauche C, Gonzaga LV, Costa ACO, Fett R (2016) Honey: chemical composition, stability and authenticity. Food Chem. 196, 309–323.
• [29] Varga T, Sajtos Z, Gajdos Z, Jull AJT, Moln´ar M et al. (2020) Honey as an indicator of long-term environmental changes: MP-AES analysis coupled with 14Cbased age determination of Hungarian honey samples. Sci. Total Environ. 736, 139686. https://doi.org/10.1016/j.scitotenv.2020.139686. in varietal
• [30] D˙ zugan M, Zaguła G, Wesołowska M, Sowa P, Puchalski C (2017) Levels of toxic and essential metals honeys from https://doi.org/10.5601/jelem.2016.21.4.1298. podkarpacie. J. Elem. 22, 1039–1048.
• [31] Yasar S, Sogutlu I (2020) Investigation of Acidity, Diastase Number, HMF, Insoluble Dry Matter and Ash Percentage Values of Some Honey Samples Produced in Bingöl and Districts. Van Vet J. 31(1), 42 45. https://doi.org/10.36483/vanvetj.631565.
• [32] Dadalı C (2021) Characterization of Volatile Compounds and Sensory Properties of Chaste (Vitex agnus-castus L.) Honeys. Türk Tarım- Gıda Bilim ve Teknoloji Dergisi, 9 (3), 621-631.
• [33] Samarghandian S, Farkhondeh T, Samini F (2017) Honey and health: a review of recent clinical research. Pharmacogn. Res. 9, 121–127.
• [34] Koca N, Karadeniz F (2003) Serbest Gıda Radikal Oluşum Mekanizmaları ve Vücuttaki Antioksidan Savunma Sistemleri. Gıda Mühendisliği Dergisi.
• [35]Mandal M, Jaganathan SK (2009) Antiproliferative effects of honey and of its polyphenols: a review. J. Biomed. Biotechnol. 830616. https://doi.org/10.1155/2009/830616.
• [36] Alzahrani HA, Boukraâ L, Bellik Y, Abdellah F, Bakhotmah BA et al. (2012) Evaluation of the Antioxidant Activity of Three Varieties of Honey from Different Botanical and Geographical Origins. Global Journal of Health Science, 4(6).
• [37] Doğan A, Kolankaya D (2005) Protective Effect of Anzer Honey Against Ethanol-Induced Increased Vascular Permeability in The Rat Stomach. Exp. Toxicologic Pathology, 57, 173–178.
• [38] Alvarez-Suarez JM, Tulipani S, Diaz D, Estevez Y, Romandini S et al. (2010). Antioxidant and antimicrobial capacity of several monofloral Cuban honeys and their correlation with color, polyphenol content and other chemical compounds. Food Chem Toxicol, 48, 2490–2499.
• [39] Martinello M, Mutinelli F (2021) Antioxidant Activity in Bee Products: A Review. Antioxidants, 10, 71. https://doi.org/10.3390/antiox10010071.
• [40] Erejuwa OO, Sulaiman SA, Wahab MSA (2014) Effects of honey and its mechanisms of action on the development and progression of cancer. Molecules,19(2): 2497-2522.
• [41] Abdel-Latif MM (2015) Chemoprevention of gastrointestinal cancers by natural honey. World Journal Pharmacology 4(1): 160-167.
• [42] Jaganathan SK, Balaji A, Vellayappan MV, Asokan MK, Subramanian AP et al. (2015) A review on antiproliferative and apoptotic activities of natural honey. Anticancer. Agents Med. Chem. 15, 48–56.
• [43] Abel SDA, Dadhwal S, Gamble AB, Baird SK. (2018) Honey reduces the metastatic characteristics of prostate lines https://doi.org/10.7717/peerj.5115. by promoting a loss of adhesion. PeerJ 6:e5115
• [44] Cianciosi D, Forbes-Hernández TY, Afrin S, Gasparrini M, Quiles JL et al. (2020). The Influence of In Vitro Gastrointestinal Digestion on the Anticancer Activity of Manuka Honey. Antioxidants. 9(1):64. https://doi.org/10.3390/antiox9010064.
• [45] Kılıçoğlu B, Kısmet K, Koru O, Tanyuksel M, Oruc MT et al. (2006) The scolicidal effects of honey. Adv Ther, 23: 1077-1083.
• [46] Aksoy Z, Dığrak M (2006) Bingöl Yöresinde Toplanan Bal ve Propolisin Antimikrobiyal Etkisi Üzerinde In Vitro Araştırmalar. Fırat Üniv. Fen ve Müh. Bil. Derg. 18 (4), 471-478.
• [47] Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N (2014) Antiinfluenza viral effects of honey in vitro: potent high activity of manuka honey. Arch. Med. Res. 45, 359–365. https://doi.org/10.1016/j.arcmed.2014.05.006.
• [48] D˙ zugan M, Grabek-Lejko D, Swacha S, Tomczyk M, Bednarska S et al. (2020) Physicochemical quality parameters, antibacterial properties and cellular antioxidant activity of Polish buckwheat honey. Food Biosci 34, 100538.
• [49] Nolan VC, Harrison J, Cox JAG (2019) Dissecting the antimicrobial composition of honey. Antibiotics 8, 251. https://doi.org/10.3390/antibiotics8040251.
• [50] Al-Hatamleh MAI, Hatmal MM, Sattar K, Ahmad S, Mustafa MZ et al. (2020). Antiviral and immunomodulatory effects of phytochemicals from honey against COVID-19: potential mechanisms of action and future directions. Molecules 25. https://doi.org/10.3390/molecules25215017.
• [51] Bogdanov S (1997). Nature and origin of the antibacterial substances in honey LWT-Food Sci. Technol. 30, 748–753.
• [52] Kurek-Górecka A, Górecki M, Rzepecka-Stojko A, Balwierz R, Stojko J (2020) Bee Products in Dermatology and Skin Care. Molecules. 25(556).
• [53] Ali AM, Kunugi H (2021) Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies. Molecule, 26, 1232. https://doi.org/10.3390/molecules26051232.
• [54] Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J et al. (2020) Withanone and withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells. J. Biomol. Struct. Dyn., 1–13.
• [55] GuoYR, Cao QD, Hong ZS, Tan YY, Chen SD et al. (2020) The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak—An update on the status. Mil. Med. Res, 7, 1–10.
• [56] Ali AM, Hendawy AO (2021) Vitamin K. Involvement in COVID-19 and possible benefits of vitamin K antagonists (VKA). Aging Clin. Exp. Res. under review.
• [57] Hossain KS, Hossain MG, Moni A, Rahman Md Mahbubur, Rahman UH, Alam M, Kundu S, Hannan MA, Uddin MJ (2020) Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises. Heliyon 6, e05798. https://doi.org/10.1016/j.heliyon.2020.e05798.
• [58] Tang JS, Compton BJ, Marshall A, Anderson R, Li Y, van derWoude H, Hermans IF, Painter GF, Gasser O (2020) Manuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells. Food Funct., 11, 5782–5787. [59] Ashraf S, Ashraf S, Ashraf M, Imran MA, Kalsoom L, Siddiqui UN, Farooq I, Habib Z, Ashraf S, Ghufran M et al (2020) Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial. medRxiv, 20217364.
• [60] Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang, JR et al. (2020). Withanone and withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells. J. Biomol. Struct. Dyn.1–13.
• [61] Güler HI, Tatar G, Yıldız O, Belduz AO, Kolayli S (2020) Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by Molecular Docking Study. ScienceOpen.
• [62] Refaat H, Mady FM, Sarhan HA, Rateb HS, Alaaeldin E (2020) Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19. Int. J. Pharm. 592, 120028.
• [63] Vijayakumar BG, Ramesh D, Joji A, Jayachandra prakasan J, Kannan T (2020) In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2. Eur. J. Pharmacol. 886, 173448. [64] Jain AS, Sushma P, Dharmashekar C, Beelagi MS, Prasad SK (2021) In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2. Saudi J. Biol. Sci. 28, 1040–1051.
• [65] da Silva FM, da Silva KP, de Oliveira LP, Costa EV, Koolen HH et al. (2020) Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA dependent RNA polymerase (RdRp). Mem. Inst. Oswaldo Cruz, 115, e200207.
• [66] Pitsillou E, Liang J, Ververis K, Hung A, Karagiannis TC (2021) Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic inhibition assay. J. Mol. Graph.Model. 107851.
• [67] Hashem H.IN (2020) Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors. EJMO 4, 96–200.