MTT-Based Assessment of the Anticancer Potential of a Known 1,2-Disubstituted Benzimidazole Compound on DLD-1 Cell Line
Öz
In this study, the cytotoxic effect of 1-(4-methylbenzyl)-2-p-tolyl-1H-benzo[d]imidazole (SL-13) was investigated on human colorectal cancer DLD-1 cells using the MTT assay. Treatment with SL-13 at various concentrations (100, 50, and 25 µM) for 72 hours resulted in a potent cytotoxic response with an IC₅₀ value of 6.093 µM, indicating strong antiproliferative activity. This potency surpasses that reported for many other benzimidazole derivatives tested against DLD-1 cells. These findings show that SL-13 is a promising candidate for further development in colorectal cancer therapy, warranting additional mechanistic and in vivo studies to elucidate its therapeutic potential.
Anahtar Kelimeler
Destekleyen Kurum
Süleyman Demirel Üniversitesi
Proje Numarası
TSG-2024-9516
Etik Beyan
Bu araştırma tamamen yerleşik kanser hücre hatları üzerinde yürütüldüğünden etik kurul onayına gerek duyulmamıştır.
Teşekkür
SA, TSG-2024-9516 numaralı projeyle sağladığı finansal destekten dolayı Süleyman Demirel Üniversitesi Araştırma Fonu'na teşekkür etmek ister.
Kaynakça
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