Associations of Nutritional Status, Oxidative Parameters, and Quality of Life of Breast Cancer Patients Before, During, and After Chemotherapy

Yıl 2022, , 242 - 252, 26.12.2022

Aysel Şahin Kaya , Tarkan Yetişyiğit , Ahsen Yılmaz , Savaş Güzel , Aslı Akyol Mutlu

https://doi.org/10.46413/boneyusbad.1189131

Öz

Aim: We aimed to assess the associations between nutritional status, oxidative parameters, and quality of life before, during, and after chemotherapy (CT) in breast cancer patients.
Material and Method: Clinical, anthropometric, demographic, quality of life, blood oxidative marker level, and dietary intake data of breast cancer patients who planned to CT were recorded. All collected data were compared between pre-CT, mid-CT, and post-CT time points.
Results: Fifty women who were diagnosed with breast cancer and would start CT treatment were included in the study. Post-CT body weight and body mass index were significantly lower than the pre-CT values (p˂0.001). They both turned back to pre-CT levels at the end of CT with a decrease in total daily caloric and macronutrient intake. Consumption of specific food groups significantly decreased compared to their pre-CT consumption levels (p˂0.001). Blood oxidative stress marker analysis revealed a significant reduction in glutathione peroxidase levels with CT (p=0.007). Analysis of the quality-of-life scores revealed that post-CT scores were significantly higher than the pre-CT scores while the life quality was lowest in the mid-CT period.
Conclusion: Adequate energy intake and antioxidant intake should be recommended to these patients during CT via dietary counseling to maintain healthy anthropometric measures, oxidative hemostasis, and quality of life.

Anahtar Kelimeler

Breast cancer, Chemotherapy, Nutritional Status, Oxidative stress, Quality of life

Destekleyen Kurum

Scientific Research Projects Coordinator of Tekirdağ Namık Kemal University

Proje Numarası

NKUBAP.02.GA.18.190

Meme Kanseri Hastalarının Kemoterapi Öncesinde, Sırasında ve Sonrasında Beslenme Durumu, Oksidatif Parametreler ve Yaşam Kalitesi İlişkisi

Öz

Amaç: Meme kanserli hastalarda kemoterapi (KT) öncesi, sırası ve sonrasında beslenme durumu, oksidatif parametreler ve yaşam kalitesi arasındaki ilişkileri değerlendirilmesi amaçlandı.
Gereç ve Yöntemler: KT planlanan meme kanserli hastaların klinik, antropometrik, demografik, yaşam kalitesi, kan oksidatif belirteç düzeyi ve diyet alım verileri kaydedildi. Toplanan tüm veriler, KT öncesi, KT ortası ve KT sonrası zaman noktaları arasında karşılaştırıldı.
Bulgular: Çalışmaya meme kanseri tanısı konan ve KT tedavisine başlanacak 50 kadın dahil edildi. KT sonrası vücut ağırlığı ve beden kütle indeksi, KT öncesi değerlerden anlamlı derecede düşüktü (p˂0,001). Her ikisi de KT'nin sonunda toplam günlük kalori ve makro besin alımında bir düşüşle KT öncesi seviyelere döndüler. Belirli gıda gruplarının tüketimi, KT öncesi tüketim düzeylerine göre önemli ölçüde azaldı (p˂0,001). Kan oksidatif stres belirteç analizi, KT ile glutatyon peroksidaz düzeylerinde önemli bir azalma olduğunu ortaya koydu (p=0,007). Yaşam kalitesi puanlarının analizi, KT sonrası puanların KT öncesi puanlardan anlamlı derecede yüksek olduğunu, KT ortasında ise en düşük olduğunu ortaya koydu.
Sonuç: Sağlıklı antropometrik ölçümler, oksidatif denge ve yaşam kalitesi sağlamak için bu hastalara KT sırasında diyet danışmanlığı yoluyla yeterli enerji alımı ve antioksidan alımı önerilmelidir.

Anahtar Kelimeler

Meme kanseri, Kemoterapi, Beslenme durumu, Oksidatif stres, Yaşam kalitesi

Proje Numarası

NKUBAP.02.GA.18.190

Kaynakça

• Al-Ajmi, K., Lophatananon, A., Ollier, W., Muir, K. R. (2018). Risk of breast cancer in the UK biobank female cohort and its relationship to anthropometric and reproductive factors. PLoS One, 13(7), e0201097. doi:10.1371/journal.pone.0201097
• Braakhuis, A. J., Campion, P., Bishop, K. S. (2016). Reducing breast cancer recurrence: the role of dietary polyphenolics. Nutrients, 8(9), 547. doi:10.3390/nu8090547
• De Cicco, P., Catani, M. V., Gasperi, V., Sibilano, M., Quaglietta, M., Savini, I. (2019). Nutrition and breast cancer: a literature review on prevention, treatment and recurrence. Nutrients, 11(7), 1514. doi:10.3390/nu11071514
• De Vries, Y., Van Den Berg, M., De Vries, J., Boesveldt, S., de Kruif, J. T., Buist, N., . . . Timmer-Bonte, J. (2017). Differences in dietary intake during chemotherapy in breast cancer patients compared to women without cancer. Supportive Care in Cancer, 25(8), 2581-2591. doi:10.1007/s00520-017-3668-x
• Fabian, C. J., Kimler, B. F., Hursting, S. D. (2015). Omega-3 fatty acids for breast cancer prevention and survivorship. Breast cancer research, 17(1), 1-11. doi:10.1186/s13058-015-0571-6
• Fisusi, F. A., Akala, E. O. (2019). Drug combinations in breast cancer therapy. Pharmaceutical nanotechnology, 7(1), 3-23. doi:10.2174/2211738507666190122111224
• Flanagan, M. R., Tang, M.-T. C., Baglia, M. L., Porter, P. L., Malone, K. E., Li, C. I. (2018). Relationship between anthropometric factors and risk of second breast cancer among women with a history of ductal carcinoma in situ. JNCI Cancer Spectrum, 2(2), pky020. doi:10.1093/jncics/pky020
• Fortner, R. T., Katzke, V., Kühn, T., Kaaks, R. (2016). Obesity and breast cancer. Recent Results in Cancer Research(208), 43-65. doi:10.1007/978-3-319-42542-9_3
• Friedenreich, C. M., Courneya, K. S., Bryant, H. E. (2002). Case‐control study of anthropometric measures and breast cancer risk. International journal of cancer, 99(3), 445-452. doi:10.1002/ijc.10389
• Gorrini, C., Harris, I. S., Mak, T. W. (2013). Modulation of oxidative stress as an anticancer strategy. Nature reviews Drug discovery, 12(12), 931-947. doi:1038/nrd4002
• Guzelant, A., Goksel, T., Ozkok, S., Tasbakan, S., Aysan, T., Bottomley, A. (2004). The European Organization for Research and Treatment of Cancer QLQ‐C30: an examination into the cultural validity and reliability of the Turkish version of the EORTC QLQ‐C30. European Journal of Cancer Care, 13(2), 135-144. doi:10.1111/j.1365- 2354.2003.00435.x
• Kaya, A. S., Pekcan, G. (2021). Evaluation of preoperative nutritional status of patients with gastrointestinal cancer using different nutritional screening tests. Progress in Nutrition, 22(3: e2020073). doi:10.23751/pn.v22i4.9339
• Lopes, J. V., Bergerot, C. D., Barbosa, L. R., Calux, N. M. d. C. T., Elias, S., Ashing, K. T., … Domenico, E. B. L. d. (2018). Impact of breast cancer and quality of life of women survivors. Revista Brasileira de Enfermagem, 71, 2916-2921. doi:10.1590/0034-7167-2018-0081
• Lubos, E., Loscalzo, J., Handy, D. E. (2011). Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxidants & Redox Signaling, 15(7), 1957-1997. doi:10.1089/ars.2010.3586
• Maajani, K., Jalali, A., Alipour, S., Khodadost, M., Tohidinik, H. R., Yazdani, K. (2019). The global and regional survival rate of women with breast cancer: a systematic review and meta-analysis. Clinical Breast Cancer, 19(3), 165-177. doi:10.1016/j.clbc.2019.01.006
• Männistö, S., Virtanen, M., Mikkonen, T., Pietinen, P. (1996). Reproducibility and validity of a food frequency questionnaire in a case-control study on breast cancer. Journal of clinical epidemiology, 49(4), 401-409. doi:10.1016/0895-4356(95)00551-x
• Maughan, K. L., Lutterbie, M. A., Ham, P. (2010). Treatment of breast cancer. American family physician, 81(11), 1339-1346.
• Najafi, S., Haghighat, S., Raji Lahiji, M., RazmPoosh, E., Chamari, M., Abdollahi, R., . . . Zarrati, M. (2019). Randomized study of the effect of dietary counseling during adjuvant chemotherapy on chemotherapy induced nausea and vomiting, and quality of life in patients with breast cancer. Nutrition and cancer, 71(4), 575-584. doi:10.1080/01635581.2018.1527375
• Neo, J., Fettes, L., Gao, W., Higginson, I. J., Maddocks, M. (2017). Disability in activities of daily living among adults with cancer: A systematic review and meta-analysis. Cancer Treatment Reviews, 61, 94-106. doi:10.1016/j.ctrv.2017.10.006
• Nwozo, S. O., Solomon, O., Abimbola, O. O., Kikelomo, D. O. (2013). Comparative study of biochemical and nutritional status of breast cancer patients on chemotherapy/radiotherapy in ibadan. American Journal of Cancer Science, 2(1), 51-60.
• Picon‐Ruiz, M., Morata‐Tarifa, C., Valle‐Goffin, J. J., Friedman, E. R., Slingerland, J. M. (2017). Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA: a cancer journal for clinicians, 67(5), 378-397. doi:10.3322/caac.21405
• Rockenbach, G., Di Pietro, P., Ambrosi, C., Boaventura, B. C. B., Vieira, F. G. K., Crippa, C. G., . . . Fausto, M. A. (2011). Dietary intake and oxidative stress in breast cancer: before and after treatments. Nutricion hospitalaria, 26(4), 737-744. doi:10.1590/S0212-16112011000400011
• Rojas, K., Stuckey, A. (2016). Breast cancer epidemiology and risk factors. Clinical obstetrics and gynecology, 59(4), 651-672. doi:10.1097/GRF.0000000000000239
• Sun, Y.-S., Zhao, Z., Yang, Z.-N., Xu, F., Lu, H.-J., Zhu, Z.-Y., . . . Zhu, H.-P. (2017). Risk factors and preventions of breast cancer. International Journal of Biological Sciences, 13(11), 1387. doi:10.7150/ijbs.21635
• Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., … Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal For Clinicians, 71(3), 209-249. doi:10.3322/caac.21660
• Wang, Z., Yin, G., Jia, R. (2019). Impacts of self-care education on adverse events and mental health related quality of life in breast cancer patients under chemotherapy. Complementary therapies in Medicine, 43, 165-169. doi:10.1016/j.ctim.2019.01.027
• WHO. International Agency for Research on Cancer, GLOBOCAN 2020. Access date: ,https://gco.iarc.fr/today/data/factsheets/populations/792-turkey-fact-sheets.pdf.