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Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures

Yıl 2025, Cilt: 7 Sayı: 3, 877 - 883, 19.12.2025
https://doi.org/10.46413/boneyusbad.1663810

Öz

Aim: The purpose of this study was to emphasize the importance of conducting a biopsy during percutaneous vertebroplasty surgery for vertebral compression fractures.
Material and Method: 73 patients with vertebral compression fractures who did not have primary malignancy or metabolic disease were included in the study. All patients had percutaneous vertebroplasty and biopsies were obtained during the procedure. Fracture levels were recorded. The patients’ preoperative and postoperative pain levels were evaluated with VAS scores.
Results: Of the 73 patients we treated, 13 were male and 60 were female. The patients’ average age was 75.60 (range 51-91). Biopsies were obtained from 116 fractured vertebral levels of a total of 73 patients. The biopsy of 1 patient (0.86%) was observed to be compatible with multiple myeloma. The mean VAS score of the patients was 9.22 preoperatively and 1.34 in the postoperative 6th week. No statistically significant relationship between fracture level or patient age and pain was found (p>0.05).
Conclusions: In the study, it was seen that even if osteoporosis is very common in the etiology of patients operated on due to VCF, it is important to take biopsies from all levels. Although rare, unexpected malignancies can be considered a cause of VCFs.

Proje Numarası

Proje çalışması değildir.

Kaynakça

  • Anselmetti, G. C., Corrao, G., Monica, P. D., Tartaglia, V., Manca, A., Eminefendic, H., … Regge, D. (2007). Pain Relief Following Percutaneous Vertebroplasty: Results of a Series of 283 Consecutive Patients Treated in a Single Institution. CardioVascular and Interventional Radiology, 30(3), 441–447. doi:10.1007/s00270-006-0146-0
  • Cooper, C., Atkinson, E. J., MichaelO’Fallon, W., & Melton, J. L. (2009). Incidence of clinically diagnosed vertebral fractures: A population-based study in rochester, minnesota, 1985-1989. Journal of Bone and Mineral Research, 7(2), 221–227. doi: 0.1002/jbmr.5650070214
  • Donnally III, C. J., DiPompeo, C. M., & Varacallo, M. (2023). Vertebral Compression Fractures. Treasure Island (FL), StatPearls Publishing.
  • Ensrud, K. E., & Schousboe, J. T. (2011). Vertebral Fractures. New England Journal of Medicine, 364(17), 1634–1642. doi: 10.1056/NEJMcp1009697
  • Ettinger, B., Black, D. M., Nevitt, M. C., Rundle, A. C., Cauley, J. A., Cummings, S. R., & Genant, H. K. (1992). Contribution of vertebral deformities to chronic back pain and disability. Journal of Bone and Mineral Research, 7(4), 449–456. doi:10.1002/jbmr.5650070413
  • Evans, A. J., Kip, K. E., & Boutin, S. M. (2009). Prospective assessment of pain and functional status after vertebroplasty for treatment of vertebral compression fractures. Journal of NeuroInterventional Surgery, 1(1), 66–70. doi:10.1136/jnis.2009.000158
  • Francis, R. M., Baillie, S. P., Chuck, A. J., Crook, P. R., Dunn, N., Fordham, J. N., … Rodgers, A. (2004). Acute and long-term management of patients with vertebral fractures. QJM, 97(2), 63–74. doi:10.1093/qjmed/hch012
  • Gangi, A., Guth, S., Imbert, J. P., Marin, H., & Dietemann, J.-L. (2003). Percutaneous Vertebroplasty: Indications, Technique, and Results. RadioGraphics, 23(2), e10–e10. doi:10.1148/rg.e10
  • Garfin, S. R., Buckley, R. A., & Ledlie, J. (2006). Balloon Kyphoplasty for Symptomatic Vertebral Body Compression Fractures Results in Rapid, Significant, and Sustained Improvements in Back Pain, Function, and Quality of Life for Elderly Patients. Spine, 31(19), 2213–2220. doi:10.1097/01.brs.0000232803.71640.ba
  • Ho, C.-S., Choi, W.-M., Chen, C., Chen, W.-Y., & Chan, W. P. (2005). Metastasis in vertebra mimicking acute compression fractures in a patient with osteoporosis. Clinical Imaging, 29(1), 64–67. doi:10.1016/j.clinimag.2004.04.025
  • Karaman, H., Kaya, S., Tufek, A., Olmez Kavak, G., Baysal Yildirim, Z., Celik, F., & Akdemir, M. S. (2012). Our percutaneous vertebroplasty applications in vertebral compression fratures. Ağrı - The Journal of The Turkish Society of Algology, 24(3), 104–110. doi:10.5505/agri.2012.64497
  • Manji, R., Ponzano, M., Ashe, M. C., Wark, J. D., Kendler, D., Papaioannou, A., … Giangregorio, L. M. (2022). Exploring the Association between Pain and Fracture Characteristics in Women with Osteoporotic Vertebral Fractures. Physiotherapy Canada, 74(2), 165–172. doi:0.3138/ptc-2020-0067
  • Masala, S., Lunardi, P., Fiori, R., Liccardo, G., Massari, F., Ursone, A., & Simonetti, G. (2004). Vertebroplasty and Kyphoplasty in the Treatment of Malignant Vertebral Fractures. Journal of Chemotherapy, 16(sup5), 30–33. doi:10.1080/1120009X.2004.11782379
  • Moulopoulos, L. A., Yoshimitsu, K., Johnston, D. A., Leeds, N. E., & Libshitz, H. I. (1996). MR prediction of benign and malignant vertebral compression fractures. Journal of Magnetic Resonance Imaging, 6(4), 667–674. doi:10.1002/jmri.1880060416
  • Muijs, S. P. J., Akkermans, P. A., van Erkel, A. R., & Dijkstra, S. D. (2009). The Value of Routinely Performing a Bone Biopsy During Percutaneous Vertebroplasty in Treatment of Osteoporotic Vertebral Compression Fractures. Spine, 34(22), 2395–2399. doi:10.1097/BRS.0b013e3181b8707e
  • Mukherjee, S., Thakur, B., Bhagawati, D., Bhagawati, D., Akmal, S., Arzoglou, … Ellamushi, H. (2014). Utility of routine biopsy at vertebroplasty in the management of vertebral compression fractures: a tertiary center experience. Journal of Neurosurgery: Spine, 21(5), 687–697. doi:10.3171/2014.7.SPINE121015
  • Oleksik, A., Lips, P., Dawson, A., Minshall, M. E., Shen, W., Cooper, C., & Kanis, J. (2000). Health-Related Quality of Life in Postmenopausal Women With Low BMD With or Without Prevalent Vertebral Fractures. Journal of Bone and Mineral Research, 15(7), 1384–1392. doi:10.1359/jbmr.2000.15.7.1384
  • O’Neill, T. W., Felsenberg, D., Varlow, J., Cooper, C., Kanis, J. A., & Silman, A. J. (2009). The prevalence of vertebral deformity in European men and women: The european vertebral osteoporosis study. Journal of Bone and Mineral Research, 11(7), 1010–1018. doi:10.1002/jbmr.5650110719
  • Phekoo, K. J., Schey, S. A., Richards, M. A., Bevan, D. H., Bell, S., Gillett, D., & Møller, H. (2004). A population study to define the incidence and survival of multiple myeloma in a National Health Service Region in UK. British Journal of Haematology, 127(3), 299–304. doi:10.1111/j.1365-2141.2004.05207.x
  • Ross, P. D. (1997). Clinical consequences of vertebral fractures. The American Journal of Medicine, 103(2), S30–S43. doi:10.1016/S0002-9343(97)90025-5
  • Rupp, R. E., Ebraheim, N. A., & Commbs, R. J. (1995). Magnetic Resonance Imaging Defferentiation of Compression Spine Fractures or Vertebral Lesions Caused by Osteoporosis or Tumor. Spine, 20(23), 2499–2503. doi:10.1097/00007632-199512000-00007
  • Schoenfeld, A. J., DiNicola, N. J., Ehrler, D. M., Koerber, A., Paxos, M., Shorten, S. D., … Smith, M. J. (2008). Retrospective review of biopsy results following percutaneous fixation of vertebral compression fractures. Injury, 39(3), 327–333. doi:10.1016/j.injury.2007.06.019
  • Shindle, M. K., Tyler, W., Edobor-Osula, F., Gardner, M. J., Shindle, L., Toro, J., & Lane, J. M. (2006). Unsuspected Lymphoma Diagnosed with Use of Biopsy During Kyphoplasty. The Journal of Bone & Joint Surgery, 88(12), 2721–2724. doi:10.2106/JBJS.F.00100
  • Sinaki, M. (2012). Exercise for Patients With Osteoporosis: Management of Vertebral Compression Fractures and Trunk Strengthening for Fall Prevention. PM&R, 4(11), 882–888. doi:10.1016/j.pmrj.2012.10.008
  • Togawa, D., Lieberman, I. H., Bauer, T. W., Reinhardt, M. K., & Kayanja, M. M. (2005). Histological Evaluation of Biopsies Obtained From Vertebral Compression Fractures: Unsuspected Myeloma and Osteomalacia. Spine, 30(7), 781–786. doi:10.1097/01.brs.0000157478.03349.57
  • Zhang, L., Li, J., Yang, H., Luo, Z., & Zou, J. (2013). Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures. Oncology Letters, 5(1), 135–138. doi:10.3892/ol.2012.944

Vertebra Kompresyon Kırıklarının Tedavisinde Uygulanan Perkütan Vertebroplasti Cerrahisinde Rutin Biyopsinin Önemi

Yıl 2025, Cilt: 7 Sayı: 3, 877 - 883, 19.12.2025
https://doi.org/10.46413/boneyusbad.1663810

Öz

Amaç: Vertebra çökme kırığı olan hastalarda kırık seviyeleri ile ağrı arasındaki ilişkiyi ve perkütan vertebroplasti cerrahisi sırasında biyopsinin gerekliliğini araştırmak.
Gereç ve Yöntem: Primer malignitesi veya metabolik hastalığı olmayan ve vertebral kompresyon kırığı olan 73 hasta çalışmaya alındı. Tüm hastalara perkutan vertebroplasti uygulandı ve işlem sırasında kemik biyopsisi alındı. Hastaların kırık seviyeleri, ameliyat öncesi ve sonrası ağrı skorları kayıt edildi. Kırık seviyeleri ve hasta yaşlarının ağrı ile arasındaki ilişki değerlendirildi.
Bulgular: Tedavi etiğimiz 73 hastanın 13’ü erkek 60’ı kadındı. Hastaların yaş ortalaması 75,60 (aralık 51-91) idi. Toplam 73 hastadan 116 kırık vertebra seviyesinden biyopsi alındı. Biyopsi materyalleri patoloji laboratuvarında incelendi. 1 (%0,86) hastanın biyopsisi multipl myelom ile uyumlu olduğu görüldü. Hastaların ameliyat öncesi VAS skoru ortalaması 9,22 iken ameliyat sonrası 6. Haftada ise 1,34 (p<0,001) olarak kayıt edildi. İstatistiksel olarak bakıldığında, kırık seviyesi ve hasta yaşı ile ağrı arasında bir ilişki saptanmadı (p>0,001).
Sonuç: Yaptığımız bu çalışmada VKK nedeni ile opere edilen hastaların etiyolojilerinde osteoporoz çok sık görülse de beklenmeyen malignensiler nadir olarak görülebilmektedir. Bu nedenle her kırk seviyesinden biyopsi almanın önemli olduğunu düşünmekteyiz. VKK da görülen ağrı kırık seviyesi ve hasta yaşlarından bağımsızdır. Perkütan vertebroplasti ile bu ağrılar hızlıca azaltılabilmektedir.

Etik Beyan

Etik kurul dosyası yüklenmiştir.

Destekleyen Kurum

yoktur.

Proje Numarası

Proje çalışması değildir.

Teşekkür

Dergide görev alan tüm akademisyen arkadaşlarıma emekleri için şimdiden çok teşekkür ederiz. İyi çalışmalar dileriz.

Kaynakça

  • Anselmetti, G. C., Corrao, G., Monica, P. D., Tartaglia, V., Manca, A., Eminefendic, H., … Regge, D. (2007). Pain Relief Following Percutaneous Vertebroplasty: Results of a Series of 283 Consecutive Patients Treated in a Single Institution. CardioVascular and Interventional Radiology, 30(3), 441–447. doi:10.1007/s00270-006-0146-0
  • Cooper, C., Atkinson, E. J., MichaelO’Fallon, W., & Melton, J. L. (2009). Incidence of clinically diagnosed vertebral fractures: A population-based study in rochester, minnesota, 1985-1989. Journal of Bone and Mineral Research, 7(2), 221–227. doi: 0.1002/jbmr.5650070214
  • Donnally III, C. J., DiPompeo, C. M., & Varacallo, M. (2023). Vertebral Compression Fractures. Treasure Island (FL), StatPearls Publishing.
  • Ensrud, K. E., & Schousboe, J. T. (2011). Vertebral Fractures. New England Journal of Medicine, 364(17), 1634–1642. doi: 10.1056/NEJMcp1009697
  • Ettinger, B., Black, D. M., Nevitt, M. C., Rundle, A. C., Cauley, J. A., Cummings, S. R., & Genant, H. K. (1992). Contribution of vertebral deformities to chronic back pain and disability. Journal of Bone and Mineral Research, 7(4), 449–456. doi:10.1002/jbmr.5650070413
  • Evans, A. J., Kip, K. E., & Boutin, S. M. (2009). Prospective assessment of pain and functional status after vertebroplasty for treatment of vertebral compression fractures. Journal of NeuroInterventional Surgery, 1(1), 66–70. doi:10.1136/jnis.2009.000158
  • Francis, R. M., Baillie, S. P., Chuck, A. J., Crook, P. R., Dunn, N., Fordham, J. N., … Rodgers, A. (2004). Acute and long-term management of patients with vertebral fractures. QJM, 97(2), 63–74. doi:10.1093/qjmed/hch012
  • Gangi, A., Guth, S., Imbert, J. P., Marin, H., & Dietemann, J.-L. (2003). Percutaneous Vertebroplasty: Indications, Technique, and Results. RadioGraphics, 23(2), e10–e10. doi:10.1148/rg.e10
  • Garfin, S. R., Buckley, R. A., & Ledlie, J. (2006). Balloon Kyphoplasty for Symptomatic Vertebral Body Compression Fractures Results in Rapid, Significant, and Sustained Improvements in Back Pain, Function, and Quality of Life for Elderly Patients. Spine, 31(19), 2213–2220. doi:10.1097/01.brs.0000232803.71640.ba
  • Ho, C.-S., Choi, W.-M., Chen, C., Chen, W.-Y., & Chan, W. P. (2005). Metastasis in vertebra mimicking acute compression fractures in a patient with osteoporosis. Clinical Imaging, 29(1), 64–67. doi:10.1016/j.clinimag.2004.04.025
  • Karaman, H., Kaya, S., Tufek, A., Olmez Kavak, G., Baysal Yildirim, Z., Celik, F., & Akdemir, M. S. (2012). Our percutaneous vertebroplasty applications in vertebral compression fratures. Ağrı - The Journal of The Turkish Society of Algology, 24(3), 104–110. doi:10.5505/agri.2012.64497
  • Manji, R., Ponzano, M., Ashe, M. C., Wark, J. D., Kendler, D., Papaioannou, A., … Giangregorio, L. M. (2022). Exploring the Association between Pain and Fracture Characteristics in Women with Osteoporotic Vertebral Fractures. Physiotherapy Canada, 74(2), 165–172. doi:0.3138/ptc-2020-0067
  • Masala, S., Lunardi, P., Fiori, R., Liccardo, G., Massari, F., Ursone, A., & Simonetti, G. (2004). Vertebroplasty and Kyphoplasty in the Treatment of Malignant Vertebral Fractures. Journal of Chemotherapy, 16(sup5), 30–33. doi:10.1080/1120009X.2004.11782379
  • Moulopoulos, L. A., Yoshimitsu, K., Johnston, D. A., Leeds, N. E., & Libshitz, H. I. (1996). MR prediction of benign and malignant vertebral compression fractures. Journal of Magnetic Resonance Imaging, 6(4), 667–674. doi:10.1002/jmri.1880060416
  • Muijs, S. P. J., Akkermans, P. A., van Erkel, A. R., & Dijkstra, S. D. (2009). The Value of Routinely Performing a Bone Biopsy During Percutaneous Vertebroplasty in Treatment of Osteoporotic Vertebral Compression Fractures. Spine, 34(22), 2395–2399. doi:10.1097/BRS.0b013e3181b8707e
  • Mukherjee, S., Thakur, B., Bhagawati, D., Bhagawati, D., Akmal, S., Arzoglou, … Ellamushi, H. (2014). Utility of routine biopsy at vertebroplasty in the management of vertebral compression fractures: a tertiary center experience. Journal of Neurosurgery: Spine, 21(5), 687–697. doi:10.3171/2014.7.SPINE121015
  • Oleksik, A., Lips, P., Dawson, A., Minshall, M. E., Shen, W., Cooper, C., & Kanis, J. (2000). Health-Related Quality of Life in Postmenopausal Women With Low BMD With or Without Prevalent Vertebral Fractures. Journal of Bone and Mineral Research, 15(7), 1384–1392. doi:10.1359/jbmr.2000.15.7.1384
  • O’Neill, T. W., Felsenberg, D., Varlow, J., Cooper, C., Kanis, J. A., & Silman, A. J. (2009). The prevalence of vertebral deformity in European men and women: The european vertebral osteoporosis study. Journal of Bone and Mineral Research, 11(7), 1010–1018. doi:10.1002/jbmr.5650110719
  • Phekoo, K. J., Schey, S. A., Richards, M. A., Bevan, D. H., Bell, S., Gillett, D., & Møller, H. (2004). A population study to define the incidence and survival of multiple myeloma in a National Health Service Region in UK. British Journal of Haematology, 127(3), 299–304. doi:10.1111/j.1365-2141.2004.05207.x
  • Ross, P. D. (1997). Clinical consequences of vertebral fractures. The American Journal of Medicine, 103(2), S30–S43. doi:10.1016/S0002-9343(97)90025-5
  • Rupp, R. E., Ebraheim, N. A., & Commbs, R. J. (1995). Magnetic Resonance Imaging Defferentiation of Compression Spine Fractures or Vertebral Lesions Caused by Osteoporosis or Tumor. Spine, 20(23), 2499–2503. doi:10.1097/00007632-199512000-00007
  • Schoenfeld, A. J., DiNicola, N. J., Ehrler, D. M., Koerber, A., Paxos, M., Shorten, S. D., … Smith, M. J. (2008). Retrospective review of biopsy results following percutaneous fixation of vertebral compression fractures. Injury, 39(3), 327–333. doi:10.1016/j.injury.2007.06.019
  • Shindle, M. K., Tyler, W., Edobor-Osula, F., Gardner, M. J., Shindle, L., Toro, J., & Lane, J. M. (2006). Unsuspected Lymphoma Diagnosed with Use of Biopsy During Kyphoplasty. The Journal of Bone & Joint Surgery, 88(12), 2721–2724. doi:10.2106/JBJS.F.00100
  • Sinaki, M. (2012). Exercise for Patients With Osteoporosis: Management of Vertebral Compression Fractures and Trunk Strengthening for Fall Prevention. PM&R, 4(11), 882–888. doi:10.1016/j.pmrj.2012.10.008
  • Togawa, D., Lieberman, I. H., Bauer, T. W., Reinhardt, M. K., & Kayanja, M. M. (2005). Histological Evaluation of Biopsies Obtained From Vertebral Compression Fractures: Unsuspected Myeloma and Osteomalacia. Spine, 30(7), 781–786. doi:10.1097/01.brs.0000157478.03349.57
  • Zhang, L., Li, J., Yang, H., Luo, Z., & Zou, J. (2013). Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures. Oncology Letters, 5(1), 135–138. doi:10.3892/ol.2012.944
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yaşlı Bakımı Hemşireliği
Bölüm Araştırma Makalesi
Yazarlar

Abdülhalim Akar 0000-0002-3153-4799

Uğur Özdemir 0000-0003-2889-8118

Proje Numarası Proje çalışması değildir.
Gönderilme Tarihi 23 Mart 2025
Kabul Tarihi 18 Temmuz 2025
Yayımlanma Tarihi 19 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 7 Sayı: 3

Kaynak Göster

APA Akar, A., & Özdemir, U. (2025). Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, 7(3), 877-883. https://doi.org/10.46413/boneyusbad.1663810
AMA Akar A, Özdemir U. Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. Aralık 2025;7(3):877-883. doi:10.46413/boneyusbad.1663810
Chicago Akar, Abdülhalim, ve Uğur Özdemir. “Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 7, sy. 3 (Aralık 2025): 877-83. https://doi.org/10.46413/boneyusbad.1663810.
EndNote Akar A, Özdemir U (01 Aralık 2025) Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 7 3 877–883.
IEEE A. Akar ve U. Özdemir, “Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures”, Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, c. 7, sy. 3, ss. 877–883, 2025, doi: 10.46413/boneyusbad.1663810.
ISNAD Akar, Abdülhalim - Özdemir, Uğur. “Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 7/3 (Aralık2025), 877-883. https://doi.org/10.46413/boneyusbad.1663810.
JAMA Akar A, Özdemir U. Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2025;7:877–883.
MLA Akar, Abdülhalim ve Uğur Özdemir. “Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, c. 7, sy. 3, 2025, ss. 877-83, doi:10.46413/boneyusbad.1663810.
Vancouver Akar A, Özdemir U. Importance of Routine Biopsy in Percutaneous Vertebroplasty Surgery Applied for the Treatment of Vertebral Compression Fractures. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2025;7(3):877-83.

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