DERİ KANSERİ HASTALARININ SERUM OKSİDATİF STRES PARAMETRELERİNİN DEĞERLENDİRİLMESİ Evaluation of Serum Oxidative Stress Parameters of Skin Cancer Patients

Yıl 2018, Cilt: 8 Sayı: 4, 134 - 138, 15.12.2018

İbrahim Halil Yavuz , Göknur Özaydın Yavuz , Serap Güneş Bilgili , Halit Demir , Canan Demir

https://doi.org/10.16919/bozoktip.452100

Cited By: 1

Öz

Giriş ve amaç: Deri kanserleri en sık görülen kanserlerden biridir. Bu kanserler non melanom

ve melanom olarak genellikle iki grup altında incelenir ve çoğu nonmelanomadır. Deri kanserlerinin

insidansı ve mortalite oranları tüm dünyada giderek artmaktadır. Bu çalışmada hücre içi

antioksidanlar olan superoksit dismutaz (SOD), katalaz (CAT), redükte glutatyon (GSH), glutatyon

redüktaz (GR), glutatyon peroksidaz (GPx) gibi moleküller ile oksidatif stres belirteci olan malondialdehit

(MDA) değerlerini deri kanseri hastalarında incelemek istedik.

Materyal ve metod: Prospektif çalışma modifiye edilen Dünya Helsinki Deklarasyonu'na göre

uygulandı. Bu çalışma üniversite hastanesinin dermatoloji departmanında yapıldı. Çalışmaya 30

deri kanseri hastası ve 30 sağlıklı gönüllü alındı. Çalışmaya katılanların serumlarında hücre içi

antioksidantlar ve malondialdehit seviyeleri değerlendirildi

Bulgular: Çalışma 33 erkek (%55), 27 kadın (%45) olmak üzere toplam 60 kişi ile gerçekleştirilmiştir.

Çalışmaya katılan kişilerin hasta ve kontrol grubuna göre yaş ve cinsiyet değişkenleri

karşılaştırılmış aralarında anlamlı farklılık saptanmamıştır (p>0.05). GPx, GR, GSH, SOD, MDA,

CAT değerlerinin, hasta ve kontrol grup ortalamaları arasındaki fark istatistik olarak önemli bulunmuştur

(p<0.05).

Sonuç: Bu çalışma deri kanseri hastalarında antioksidan serum düzeylerinin azaldığını ve oksidatif

stres belirteci olan MDA’nın yüksek olduğunu göstermiştir.

Anahtar Sözcu¨kler: Deri kanseri; Superoksit dismutaz; Katalaz

ABSTRACT

Introduction and objectives: Skin cancers are one of the most common cancers. These

cancers are usually examined under two groups as non-melanomas and melanomas, and most

nonmelanomas are . The incidence and mortality rates of skin cancers are increasing all over the

world. In this study, we want to investigated the intracellular antioxidants such as superoxide

dismutase (SOD), catalase (CAT), reductase glutathione (GSH), glutathione reductase (GR),

glutathione peroxidase (GPx) and malondialdehyde (MDA) values, which are oxidative stress

markers, in skin cancer patients

Material and method: The prospective study was carried out according to the modified World

Helsinki Declaration. This study was done in the dermatology department of the university

hospital. Thirty skin cancer patients and 30 healthy volunteers were included in the study.

Intracellular antioxidants and levels of malondialdehyde were evaluated of participants in the

study

Results: The study consisted of 33 men (55%) and 27 women (45%). There was no significant

difference between the age and gender variables of the study participants according to the

patient and control group (p>0.05). The difference between GPx, GR, GSH, SOD, MDA, CAT

values, patient and control group averages were statistically significant (p<0.05).

Conclusion: This study has shown that antioxidant serum levels are decreased in skin cancer

patients and MDA, an oxidative stress marker, is high.

Keywords: Skin cancer; Superoxide dismutase; Catalase

Bu çalışma Yüzüncüyıl Üniversitesi Bilimsel Araştırma Başkanlığı tarafından, 2015-TF-B321 numaralı

proje ile desteklenmiştir.

Anahtar Kelimeler

Deri kanseri, superoksit dismutaz, katalaz

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