KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease

Yıl 2021, Cilt: 11 Sayı: 1, 22 - 28, 15.03.2021

Mehmet Kış , Elton Soydan Tuba Tatlı Kış Gülden Hakverdi

Öz

ÖZET
Amaç: Endotel fonksiyon bozukluğu koroner arter hastalığı gelişiminde ve prognozunda önemli rol oynar.
Koroner arter hastalığında, uzun süreli ortalama glisemik indeksi gösteren bir parametre olan glikolize hemoglobinin (HbA1c) endotel fonksiyonları üzerine etkilerini değerlendirmeyi amaçladık.
Gereç ve Yöntemler: Koroner anjiyografi ile belgelenmiş koroner arter hastalığı olan 56 hasta çalışmaya dahil
edildi. Akım aracılı vazodilatasyon (AAD) testi ile endotel fonksiyonları değerlendirildi. İstatistiksel analiz için
IBM SPSS Statistics 25.0 programı kullanıldı. Nümerik değişkenlerin normal dağılıma uygunluğu Kolmogorov-Smirnov (n≥50) testiyle incelendi. HbA1c ve AAD yüzdelik değişim arasındaki korelasyonu değerlendirmek için Spearman korelasyon analizi kullanıldı.
Bulgular: Çalışmaya dahil edilen 56 hastanın ortalama yaşı 61,5±10,3 yıldır. Hastaların %71’ i erkek, %29’
u kadın ve ortalama vücut kitle indeksi 27,5±5,5 kg/m2’dir. AAD testinde ortalama radial arter bazal çapı
0,25 (±0,028) cm, AAD sonrası ortalama radial arter çapı 0,28 (±0,033) cm olarak saptandı. HbA1c düzeyleri
ile endotel fonksiyonlarını gösteren arter çapındaki yüzdelik değişim arasında negatif yönde zayıf bir ilişki
olduğu görüldü (r=-0,306, p=0,022).
Sonuç: Koroner arter hastalığında, uzun süreli ortalama glisemik indeksi gösteren HbA1c düzeyleri endotel
fonksiyon bozukluğunda bağımsız bir faktör olarak düşünülebilir.
Anahtar Kelimeler: Koroner Arter Hastalığı; Endotel Fonksiyonu; Hba1c
ABSTRACT
Objective: Endothelial dysfunction plays an important role in the development and prognosis of coronary
artery disease. We aimed to evaluate the effects of glycolyzed hemoglobin (HbA1c), which is a parameter
that shows the long-term mean glycemic index, on endothelial functions in coronary artery disease.
Material and Methods: Fifty-six patients who has coronary artery disease documented by coronary angiography were included in this study. Endothelial functions were evaluated by flow-mediated vasodilation
(FMD) test. IBM SPSS Statistics 25.0 program was used for statistical analysis. The suitability of numerical
variables to normal distribution was examined with Kolmogorov Smirnov (n≥50) test. Spearman correlation
analysis was used to evaluate the correlation between HbA1c and FMD percent change.
Results: The average age of 56 patients included in this study was 61.5 ± 10.3 years. 71% of the patients are
male, 29% of patients are female and mean body mass index is 27.52 ± 5.54 kg / m2. In the FMD test, the
mean radial artery basal diameter was 0.25 (±0.028) cm, and the mean radial artery diameter after FMD was
0.28 (± 0.033) cm. A negative correlation was observed between HbA1c levels and the percentage change in
artery diameter that was showed endothelial functions (r = -0.306, p = 0.022).
Conclusion: In coronary artery disease, HbA1c levels that showing long-term mean glycemic index can be
considered as an independent factor in endothelial dysfunction.
Keywords: Coronary Artery Disease; Endothelial Function; Hba1c

Anahtar Kelimeler

KORONER ARTER HASTALIĞINDA HbA1c DÜZEY, ENDOTEL FONKSİYONLAR, ARASINDAKİ İLİŞKİ

Kaynakça

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