Malezya’da Bitkilerin Erkek Doğurganlık Arttırıcı Özelliklerine Yönelik Hayvan Çalışmaları: Son 16 Yılın Bir Değerlendirmesi

Öz

İnfertilite, ulusal ve küresel önemi olan ciddi bir halk sağlığı konusudur. İnfertilite prevalansının artıyor olması endişe verici bir senaryodur. Doğal ürünlerden erkeklerde fertiliteyi arttırıcı ajanlar arayışında bitki kökenli ilaçların önemi uzun bir süredir bilinmektedir. Bu çalışma, erkek fertilite verimliliğini arttıran çeşitli bitki araştırmaları yaklaşımlarını özetlemektedir ki bu çalışılmaların bir kısmında bitkiler bizzat kullanılmıştır, bazılarında bitkiden bileşiklerin izole edilmesi için ekstrakt elde edilmiştir, diğer bir kısmı ise farklı hayvan modellerinde denenen aktik bileşiklerdir. Araştırılan literatür, 2000’li yıllardan 2016’ya 16 yıllık çalışmaları kapsamakta olup bunlarda yaklaşık 12 bitkinin erkek fertilite aktivitesine etkilerini gösterilmiştir. Sonuç olarak, bu araştırma, dünyadaki erkeklerde doğurganlık sorununu iyileştirmede gelecekteki bitki uyumu keşfi ne odaklanmada diğer araştırmacılara yardımcı olacaktır.

Anahtar Kelimeler

• Herbal bitki,üreme sistemi,doğurganlık,hayvan çalışmaları

Animal Studies on Male Fertility Enhancing Properties of Plants In Malaysia: A Review of The Past 16 Years

Öz

Infertility is an issue of global and national public health concern. It is a worrying scenario with increasing number of prevalence in infertility. The importance of drugs of plant origin in the quest of fertility enhancing agents for the male from natural products has long been recognized. The present review is an attempt to summarize the fertility enhancing plants with various approaches which are: part of plant have been used, type of extract for isolating the compounds, different isolated compounds (active principles) along with different animal model used. The literature covered is of 16 years from 2000 to 2016 for around 12 plants showing improving fertility activity in males. In conclusion, this review will help other researchers in focusing future herb based drug discovery in improving fertility problem among male across the globe

Anahtar Kelimeler

• herbal plant,reproductive system,fertility,animal study

Kaynakça

1. 1. Nada EA, El Taieb MA, Ibrahim HM, Al Saied AE. Effi cacy of tamoxifen References and l-carnitine on sperm ultra structure and seminal oxidative stres in patients with idiopathic oligoasthenoteratozoospermia. Andrologia. 2015;47(7):801-10.
2. 2. Dasuki M, Wan M, Hasnan J, Siti Amrah S, D’Souza U. Effetcs of 50% ethanolic extract of Andrographis paniculata on sexual behavior and serum hormonal assay in male Sprague Dawley rats. International Journal of Applied Biology and Pharmaceutical Technology. 2015;6(1):165–171.
3. 3. Kenjale R, Shah R, Sathaye S. Effects of Chlorophytum borivilianum on sexual behaviour and sperm count in Male mats. Phytotherpy Research. 2008;22:796–801.
4. 4. Giribabu N, Kumar KE, Rekha SS, Muniandy S, Salleh, N. Chlorophytum borivilianum (Safed Musli) root extract prevents impairment in characteristics and elevation of oxidative stress in sperm of streptozotocin-induced adult male diabetic Wistar rats. BMC Complementary and Alternative Medicine. 2014;14(1):291.
5. 5. Ang, HH, Cheang HS, Ahmad Pauzi MY. Effects of Eurycoma longifolia jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Experimental Animals / Japanese Association for Laboratory Animal Science. 2000; 49(1): 35–38.
6. 6. Mahanem MN, Abu Hassan Shaari MN, Lukman CH. The Effect of Eurycoma Longifolia Jack (Tongkat Ali) on Sexual Behaviour and Sperm Quality in Rats. Malaysian Journal of Pharmaceutical Sciences. 2004;2(1):53–60.
7. 7. Chan KL, Low BS, Teh CH, Das PK. The effect of Eurycoma longifolia on sperm quality of male rats. Natural Product Communications. 2009;4(10):1331–1336.
8. 8. Norhazlina, AW, Norfi lza MM, Wan Nurul Heriza AH, Das S. The effect of Eurycoma longifolia Jack on spermatogenesis in estrogentreated rats. Clinics. 2010;65(1):93–98.

9. 9. Low BS, Das PK, Chan KL. Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic-pituitary-gonadal axis. Journal of Ethnopharmacology. 2013;145(3):706–714.
10. 10. Amal Salem Farag M, Mahanem MN. Comparative study on the effect of Eurycoma longifolia and Smilax myosotifl ora on male rats fertility. AIP Conference Proceedings. 2013;1571:227–233.
11. 11. Nurdiana S, Mohd Idzham AZ, Zanariah A, Mohd Luqman Hakim MN. Effect of Ficus deltoidea leaves extracts on blood clotting, sperm quality and testosterone level in alloxan-induced male diabetic rats. International Journal of Pharmaceutical Sciences Review and Research. 2011;13(1):111–114.
12. 12. Samsulrizal N, Awang Z, MohdNajib MLH, Idzham M, Zarin A. Effect of Ficus deltoidea leaves extracts on sperm quality, LDH-C 4 activity and testosterone level in alloxan-induced male diabetic rats. IEEE Colloquium on Humanities, Science and Engineering. 2011. http:// doi.org/10.1109/CHUSER.2011.6163864
13. 13. Hakim P, Halimah AS, Mahanem MN. Effects of Gynura procumbens extract and glibenclamide on sperm quality and specifi c activity of testicular lactate dehydrogenase in streptozotocin-induced diabetic rats. Malaysian Journal of Biochemistry and Molecular Biology. 2008;16(2):10–14.
14. 14. Muhd Hanis MI, Siti Balkis B, Mohamad O, Jamaludin M. Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats. EXCLI Journal. 2012;11:659–669.
15. 15. Farid AA, Mahanem MN. Ethanol extract of dragon fruit and its effects on sperm quality and histology of the testes in mice.Biomedical Research. 2010;21(2):126–130.
16. 16. Nor-Raidah R, Mahanem MN. Enhancement of fertility and libido in male sprague dawley rats following the administration of aqueous extract of Lunasia amara. Malaysian Applied Biology. 2015;44(1):125–131.
17. 17. Mohamad Syamsudin MD, Wan Mastura SM, Arifah AK, Fuzina NH. Effect of short-term ingestion of the methanolic extract of Mitragyna speciosa on sperm quality in mice. In Seminar on Veterinary Sciences. 2011:51–57.
18. 18. Saheera K, Munirah S, Suzanah AR. Effects on mouse spermatogenesis and DNA fragmentation following exposure to cyclophosphamide and thymoquinone. European International Journal of Science and Technology. 2013;2(7):119–136.
19. 19. Suzanah AR, Noor Faridah SD, Shaik Sadak B, Saheera K. Protective effect of black seed Nigella sativa (L.) against cyclophosphamideinduced toxicity on reproductive and acrosomal function in mice.
20. Middle East Journal of Scientifi c Research. 2013;17(7):955–964. 20. Suzanah AR, Norul Athirah MA, Shaik Sadak B, Saheera K. Impact of thymoquinone supplementation on immobilisation stressinduced changes in reproductive characteristics of male mice. Journal of Applied and Natural Science. 2014;6(1):1–5.
21. 21. Lina S, Hashida NH, Eliza H. Role of Habbatus sauda towards the histological features of nicotine treated male rats seminal vesicle and prostate gland. Biomedical Research. 2014; 25(1):11–18.
22. 22. Ping NC, Noor Hashida H, Durriyyah Sharifah HA. Effects of Nigella sativa (Habbatus sauda) oil and nicotine chronic treatments on sperm parameters and testis histological features of rats. EvidenceBased Complementary and Alternative Medicine. 2014:1–7.
23. 23. Assi MA, Hezmee MNM, Abba Y, Rajion MA, Wahid H, Yusof MSM. Assessment of therapeutic effects of Nigella sativa against chronic lead acetate-induced reproductive dysfunction in male Sprague-Dawley rats. Comparative Clinical Pathology. 2016 http:// doi.org/10.1007/s00580-016-2349-3.
24. 24. Parhizkar S, Maryam Jamielah Y, Mohammad Aziz D. Effect of Phaleria macrocarpa on sperm characteristics in adult rats. Advanced Pharmaceutical Bulletin. 2013;3(2):345–352.
25. 25. Parhizkar S, Suriani BZ, Mohammad Aziz D. Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract. Iranian Journal of Basic Medical Sciences. 2014;17:384–390.
26. 26. Noor H, Juing M, Chee BJ, Kueh BL, Zolkepli O. Medicinal properties of Plantago major: Hypoglycaemic and male fertility studies. Pertanika J. Trp. Agric. Sci. 2000;23(1):29–35.
27. 27. Mocé, E, Graham JK. In vitro evaluation of sperm quality. Animal Reproduction Science. 2008;105(1–2):104–118.