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Lipid Peroxidation Inhibition Activities of Phenolic Compounds and Therapeutic Potential of Thymoquinone

Yıl 2020, Cilt: 34 Sayı: 2, 397 - 416, 01.12.2020

Şeyma Yıldız Semra Turan

Öz

The oxidation of fats which have an important place in living life with different factors leads to loss of food and quality. Antioxidants are used to inhibit oxidative reactions. The antioxidative effect is known as one of the most important biological activities of phenolic compounds. Thymoquinone, the main active component of black cumin essential oil, has protective and therapeutic effects and has been the subject of research in many studies due to its therapeutic properties. In this review, free radicals, antioxidants, lipid oxidation, measuring methods for lipid oxidation, phenolic compounds and their potential to prevent lipid oxidation, thymoquinone and its therapeutic potential, antioxidant, antifungal, antiviral and antibacterial activity were evaluated.

Anahtar Kelimeler

Antioxidant activity phenolic compounds lipid oxidation free radicals thymoquinone

Kaynakça

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Fenolik Bileşiklerin Lipit Oksidasyonunu Önleme Aktiviteleri ve Timokinonun Terapötik Özellikleri

Yıl 2020, Cilt: 34 Sayı: 2, 397 - 416, 01.12.2020

Şeyma Yıldız Semra Turan

Öz

Canlı yaşamında önemli yeri olan yağların farklı etkenler ile oksidasyona uğraması besin ve kalite kaybına yol açmaktadır. Oksidatif reaksiyonlarla mücadele etmek için antioksidanlar kullanılmaktadır. Antioksidatif etki fenolik bileşiklerin en önemli biyolojik aktivitelerinden biri olarak bilinmektedir. Koruyucu ve tedavi edici etkileri bulunan ve çörekotu esansiyel yağının ana aktif bileşeni olan timokinon da sahip olduğu terapötik özelliklerden dolayı birçok çalışmada araştırma konusu olmuştur. Bu derlemede serbest radikaller, antioksidanlar, lipit oksidasyonu, lipit oksidasyonu ölçüm yöntemleri, fenolik bileşikler ve lipit oksidasyonunu önleme aktiviteleri ile timokinonun yapısı, koruyucu ve tedavi edici özellikleri, antioksidan, antifungal, antiviral ve antibakteriyel etkileri üzerine yapılan çalışmalar değerlendirilmiştir.

Anahtar Kelimeler

Antioksidan Aktivite Fenolik Bileşikler lipit oksidasyonu serbest radikaller timokinon

Kaynakça

  • Ahmed, M., Pickova, J., Ahmad, T., Liaquat, M., Farid, A. and Jahangir, M. 2016. Oxidation of lipids in foods. Sarhad Journal of Agriculture, 32 (3), 230-238.
  • Almshawit, H. and Macreadie, I. 2017. Fungicidal effect of thymoquinone involves generation of oxidative stress in Candida glabrata. Microbiological Research, 195, 81-88.
  • Al-Thobity, A., Al-Khalifa, K., Gad, M., Al-Hariri, M., Ali, A. and Alnassar, T. 2017. In vitro evaluation of the inhibitory activity of thymoquinone in combatting Candida albicans in denture stomatitis prevention. International Journal of Environmental Research and Public Health, 14 (7), 743, 1-9.
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  • Laguerre, M., Lecomte, J. and Villeneuve, P. 2007. Evaluation of the ability of antioxidants to counteract lipid oxidation: Existing methods, new trends and challenges. Progress in Lipid Research, 46 (5), 244-282.
  • Li, Z.J., Yang, F.J., Yang, L. and Zu, Y.G. 2018. Comparison of the antioxidant effects of carnosic acid and synthetic antioxidants on tara seed oil. Chemistry Central Journal, 12 (1), 37.
  • Lobo, V., Patil, A., Phatak, A. and Chandra, N. 2010. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews, 4 (8), 118-126.
  • Meral, I., Pala, M., Akbas, F., Ustunova, S., Yildiz, C. and Demirel, M.H. 2018. Effects of thymoquinone on liver mirnas and oxidative stress in Ehrlich acid mouse solid tumor model. Biotechnic & Histochemistry, 93 (4), 301-308.
  • Meydan, S., Esrefoglu, M., Selek, S., Akbas Tosunoglu, E., Ozturk, O., Kurbetli, N. and Meral, I. 2019. Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity. Biotechnic & Histochemistry, 94(4), 277-282.
  • Mezza, G.N., Borgarello, A.V., Grosso, N.R., Fernandez, H., Pramparo, M.C. and Gayol, M.F. 2018. Antioxidant activity of rosemary essential oil fractions obtained by molecular distillation and their effect on oxidative stability of sunflower oil. Food Chemistry, 242, 9-15.
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  • Özdemir, N., Kantekin-Erdogan, M.N., Tat, T. and Tekin, A. 2018. Effect of black cumin oil on the oxidative stability and sensory characteristics of mayonnaise. Journal of Food Science and Technology, 55 (4), 1562-1568.
  • Passos, R.B.D., Bazzo, G.C., Almeida, A.D.R. and Noronha, C.M. 2019. Evaluation of oxidative stability of mayonnaise containing poly ε-caprolactone nanoparticles loaded with thyme essential oil. Brazilian Journal of Pharmaceutical Sciences, 55, e18177, 1-6.
  • Ponnampalam, E.N., Plozza, T., Kerr, M.G., Linden, N., Mitchell, M., Bekhit, A.E.D.A. And Hopkins, D.L. 2017. Interaction of diet and long ageing period on lipid oxidation and colour stability of lamb meat. Meat Science, 129, 43-49. Porter, N.A., Caldwell, S.E. and Mills, K.A. 1995. Mechanisms of free radical oxidation of unsaturated lipids. Lipids, 30 (4), 277-290.
  • Ramadan, M.F. and Mörsel, J.T. 2004. Oxidative stability of black cumin (Nigella sativa L.), coriander (Coriandrum sativum L.) and niger (Guizotia abyssinica Cass.) crude seed oils upon stripping. European Journal of Lipid Science and Technology, 106 (1), 35-43.
  • Ramadan, M.F. and Wahdan, K.M.M. 2012. Blending of corn oil with black cumin (Nigella sativa) and coriander (Coriandrum sativum) seed oils: Impact on functionality, stability and radical scavenging activity. Food Chemistry, 132 (2), 873-879.
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  • Rossi, M., Alamprese, C. and Ratti, S. 2007. Tocopherols and tocotrienols as free radical-scavengers in refined vegetable oils and their stability during deep-fat frying. Food Chemistry, 102 (3), 812-817.
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  • Sanati, A.R., Farkhondeh, T. and Samarghandian, S. 2018. Antidotal effects of thymoquinone against neurotoxic agents. Interdisciplinary Toxicology, 11 (2), 122-128.
  • Sangi, S.M.A., Sulaiman, M.I., El-Wahab, M.F.A., Ahmedani, E.I. and Ali, S.S. 2015. Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals. Pharmacognosy Magazine, 11 (Suppl 2), S251-257.
  • Saoudi, S., Chammem, N., Sifaoui, I., Jiménez, I.A., Lorenzo‐Morales, J., Piñero, J.E. and L Bazzocchi, I. 2017. Combined effect of carnosol, rosmarinic acid and thymol on the oxidative stability of soybean oil using a simplex centroid mixture design. Journal of the Science of Food and Agriculture, 97 (10), 3300-3311.
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Toplam 101 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Gıda Mühendisliği
Bölüm Derleme
Yazarlar

Şeyma Yıldız Bu kişi benim 0000-0002-7323-7741

Semra Turan 0000-0002-1005-3590

Yayımlanma Tarihi 1 Aralık 2020
Gönderilme Tarihi 21 Kasım 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 34 Sayı: 2

Kaynak Göster

APA Yıldız, Ş., & Turan, S. (2020). Fenolik Bileşiklerin Lipit Oksidasyonunu Önleme Aktiviteleri ve Timokinonun Terapötik Özellikleri. Bursa Uludağ Üniversitesi Ziraat Fakültesi Dergisi, 34(2), 397-416.
 Kapak Resmi İndir

TR Dizin kriterleri gereği dergimize gönderilecek olan makalelerin mutlaka aşağıda belirtilen hususlara uyması gerekmektedir.

Tüm bilim dallarında yapılan, ve etik kurul kararı gerektiren klinik ve deneysel insan ve hayvanlar üzerindeki çalışmalar için ayrı ayrı etik kurul onayı alınmış olmalı, bu onay makalede belirtilmeli ve belgelendirilmelidir.
Makalelerde Araştırma ve Yayın Etiğine uyulduğuna dair ifadeye yer verilmelidir.
Etik kurul izni gerektiren çalışmalarda, izinle ilgili bilgiler (kurul adı, tarih ve sayı no) yöntem bölümünde ve ayrıca makale ilk/son sayfasında yer verilmelidir.
Kullanılan fikir ve sanat eserleri için telif hakları düzenlemelerine riayet edilmesi gerekmektedir.
Makale sonunda; Araştırmacıların Katkı Oranı beyanı, varsa Destek ve Teşekkür Beyanı, Çatışma Beyanı verilmesi.
Etik Kurul izni gerektiren araştırmalar aşağıdaki gibidir.
- Anket, mülakat, odak grup çalışması, gözlem, deney, görüşme teknikleri kullanılarak katılımcılardan veri toplanmasını gerektiren nitel ya da nicel yaklaşımlarla yürütülen her türlü araştırmalar
- İnsan ve hayvanların (materyal/veriler dahil) deneysel ya da diğer bilimsel amaçlarla kullanılması,
- İnsanlar üzerinde yapılan klinik araştırmalar,
- Hayvanlar üzerinde yapılan araştırmalar,
- Kişisel verilerin korunması kanunu gereğince retrospektif çalışmalar,
Ayrıca;
- Olgu sunumlarında “Aydınlatılmış onam formu”nun alındığının belirtilmesi,
- Başkalarına ait ölçek, anket, fotoğrafların kullanımı için sahiplerinden izin alınması ve belirtilmesi,
- Kullanılan fikir ve sanat eserleri için telif hakları düzenlemelerine uyulduğunun belirtilmesi.



Makale başvurusunda;

(1) Tam metin makale, Dergi yazım kurallarına uygun olmalı, Makalenin ilk sayfasında ve teşekkür bilgi notu kısmında Araştırma ve Yayın Etiğine uyulduğuna ve Etik kurul izni gerektirmediğine dair ifadeye yer verilmelidir. Etik kurul izni gerektiren çalışmalarda, izinle ilgili bilgiler (kurul adı, tarih ve sayı no) yöntem bölümünde ve ayrıca makale ilk/son sayfasında yer verilmeli ve sisteme belgenin yüklenmesi gerekmektedir. (Dergiye gönderilen makalelerde; konu ile ilgili olarak derginin daha önceki sayılarında yayımlanan en az bir yayına atıf yapılması önem arz etmektedir. Dergiye yapılan atıflarda “Bursa Uludag Üniv. Ziraat Fak. Derg.” kısaltması kullanılmalıdır.)

(2) Tam metin makalenin taratıldığını gösteren benzerlik raporu (Ithenticate, intihal.net) (% 20’nin altında olmalıdır),

(3) İmzalanmış ve taratılmış başvuru formu, Dergi web sayfasında yer alan başvuru formunun başvuran tarafından İmzalanıp, taratılarak yüklenmesi , (Ön yazı yerine)

(4) Tüm yazarlar tarafından imzalanmış telif hakkı devir formunun taranmış kopyası,

(5) Araştırmacıların Katkı Oranı beyanı, Çıkar Çatışması beyanı verilmesi Makale sonunda; Araştırmacıların Katkı Oranı beyanı, varsa Destek ve Teşekkür Beyanı, Çatışma Beyanı verilmesi ve sisteme belgenin (Tüm yazarlar tarafından imzalanmış bir yazı) yüklenmesi gerekmektedir.

Belgelerin elektronik formatta DergiPark sistemine https://dergipark.org.tr/tr/login adresinden kayıt olunarak başvuru sırasında yüklenmesi mümkündür. 


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Journal of Agricultural Faculty of Bursa Uludag University is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.