Investigation of the Association Between Motor Functions with Quality of Life and Daily Living Activities in Children with Acute Lymphoblastic Leukemia

Yıl 2021, Cilt: 8 Sayı: 3, 426 - 430, 30.09.2021

Vesile Yıldız Kabak , Fulya İpek Şule Ünal Songul Atasavun Uysal , Tülin Düger

https://doi.org/10.34087/cbusbed.839071

Öz

Objective: The aim of the present study was to investigate association between motor functions and quality of life level and activities of daily living (ADL) in children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy.
Materials and Methods: The present study conducted at Hacettepe University Children Hospital. Children diagnosed with ALL and continue to maintenance chemotherapy, between the age of 4 to 15 years were included. Motor functions were assessed using The Bruininks-Oseretsky Test of Motor Proficiency-Second Edition Short Form, grip strength, the 9-Hole Peg Test, and the 30-second Sit to Stand Test. The Pediatric Quality of Life Questionnaire (PedsQL)-Cancer Module was used to determine quality of life level. The functional independent measure for children (WeeFIM) was used to determine ADL.
Results: A total of 32 (Girl: 15/Boy: 17) children were included in the present study. The mean age of the children was 8.64±3.38 years. According to the correlation analysis, the 30-second Sit to Stand Test score and bilateral coordination score were moderately correlated with the PedsQL-Cancer Module (p˂0.05). The WeeFIM score was moderate to highly associated with The Bruininks-Oseretsky Test of Motor Proficiency-Second Edition Short Form total score, grip strength, and the 9-Hole Peg Test score (p˂0.05).
Conclusion: Increase in gross and fine motor functions provide to improve in functionality in daily life and quality of life level in children with ALL when receiving chemotherapy. For this reason, children diagnosed with ALL should be followed in terms of motor functions.

Anahtar Kelimeler

Acute lymphoblastic leukemia, Children, Functional performance, Quality of life.

Akut Lenfoblastik Lösemili Çocuklarda Motor Fonksiyonlar ile Yaşam Kalitesi ve Günlük Yaşam Aktiviteleri Arasındaki İlişkinin Araştırılması

Öz

Giriş ve Amaç: Çalışmamızın amacı, idame kemoterapisi alan akut lenfoblastik lösemili (ALL) çocuklarda motor fonksiyonlar ile yaşam kalitesi ve günlük yaşam aktiviteleri (GYA) arasındaki ilişkinin araştırılmasıydı.
Gereç ve Yöntemler: Çalışmamız, Hacettepe Üniversitesi Çocuk Hastanesi’nde gerçekleştirildi. Çalışmaya ALL tanısı alan ve idame kemoterapisine devam eden, 4 ve 15 yaşları arasındaki çocuklar dahil edildi. Motor fonksiyonlar, Bruininks-Oseretsky Motor Yeterlik Testi-2. Versiyon Kısa Formu, kavrama kuvveti, 9-Delikli Peg Testi ve 30-saniye Otur-Kalk Testi ile değerlendirildi. Çocuklar İçin Yaşam Kalitesi Ölçeği (ÇİYKÖ)-Kanser Modülü yaşam kalitesi düzeyini belirlemede kullanıldı. Çocuklar İçin Fonksiyonel Bağımsızlık Ölçeği (WeeFIM) GYA düzeyini değerlendirmede kullanıldı.
Bulgular: Çalışmamıza toplam 32 çocuk (Kız: 15/Erkek: 17) dahil edildi. Çocukların ortalama yaşı 8,64±3,38 yıldı. Korelasyon analizlerine göre, 30-saniye Otur-Kalk Testi ve bilateral koordinasyon skoru, ÇİYKÖ-Kanser Modülü skoruyla orta derecede koreleydi (p˂0,05). WeeFIM toplam puanı ise Bruininks-Oseretsky Motor Yeterlik Testi-2. Versiyon Kısa Formu toplam puanı, kavrama kuvveti ve 9-Delikli Peg Testi skoru ile orta-yüksek derecede ilişkili bulundu (p˂0,05).
Sonuç: ALL’li çocukların kemoterapi aldıkları dönemde motor becerilerindeki artış, günlük hayattaki fonksiyonelliğin ve yaşam kalitelerinin gelişmesi ile ilişkilidir. Bu sebeple, ALL tanısı almış çocuklar motor beceriler açısından dikkatli takip edilmelidir.

Anahtar Kelimeler

Akut lenfoblastik lösemi, çocuk, fonksiyonel performans, yaşam kalitesi

Kaynakça

• Johnston, W.T, Erdmann, F, Newton, R, Steliarova-Foucher, E, Schuz, J, Roman,, E, Childhood cancer: Estimating regional and global incidence, Cancer Epidemiology, 2020, 101662.
• Hunger, S.P, Loh, M.L, Whitlock, J.A, Winick, N.J, Carroll, W.L, Devidas, M, Raetz, E.A, Children's Oncology Group's 2013 blueprint for research: acute lymphoblastic leukemia, Pediatric Blood & Cancer, 2013, 60, 957-63.
• Gatta, G, Botta,, L, Rossi S, Aareleid, T, Bielska-Lasota, M, Clavel, J, Dimitrova N, etal., Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5--a population-based study, The Lancet Oncology, 2014, 15, 35-47.
• Hanna, S, Elshennawy, S, El-Ayadi, M, Abdelazeim, F, Investigating fine motor deficits during maintenance therapy in children with acute lymphoblastic leukemia, Pediatric Blood & Cancer, 2020, 67, e28385.
• Ness, K.K, Hudson, M.M, Pui, C.H, Green, D.M, Krull, K.R, Huang, T.T, Robison, L.L, Morris, E.B, Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses, Cancer, 2012, 118, 828-38.
• Pui, C.H, Relling, M.V, Sandlund, J.T, Downing, J.R, Campana, D, Evans WE, Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia, Annals of Hematology, 2004, 83, 124-6.
• Reinders-Messelink, H, Schoemaker, M, Snijders, T, Goeken, L, van Den Briel, M, Bokkerink, J, Kamps, W, Motor performance of children during treatment for acute lymphoblastic leukemia, Medical Pediatric Oncology, 1999, 33, 545-50.
• Söntgerath, R, Eckert, K, Impairments of Lower Extremity Muscle Strength and Balance in Childhood Cancer Patients and Survivors: A Systematic Review, Pediatric Hematology and Oncology, 2015, 32, 585-612.
• Yildiz Kabak, V, Calders, P, Duger, T, Mohammed, J, van Breda, E, Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review, Supportive Care in Cancer, 2019, 27, 69-86.
• Rueegg, C.S, Michel, G, Wengenroth, L, von der Weid, N.X, Bergstraesser, E, Kuehni, C.E, Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings, PloS one, 2012, 7, e47944.
• Punyko, J.A, Gurney, J.G, Scott Baker, K, Hayashi, R.J, Hudson, M.M, Liu, Y, Robison, L.L, Mertens, A.C, Physical impairment and social adaptation in adult survivors of childhood and adolescent rhabdomyosarcoma: A report from the Childhood Cancer Survivors Study, Psycho-oncology, 2007, 16, 26-37.
• Götte, M, Kesting, S.V, Winter, C.C, Rosenbaum, D, Boos, J, Motor performance in children and adolescents with cancer at the end of acute treatment phase, European Journal of Pediatrics, 2015, 174, 791-9.
• Wind, A.E, Takken, T, Helders, P,J, Engelbert, R.H, Is grip strength a predictor for total muscle strength in healthy children, adolescents, and young adults? European Journal of Pediatrics, 2010, 169, 281-287.
• Deitz, J.C, Kartin, D, Kopp, K, Review of the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2), Physical & Occupational Therapy in Pediatrics, 2007, 27, 87-102.
• Wang, Y.C, Magasi, S.R, Bohannon, R.W, Reuben, D.B, McCreath, H.E, Bubela, D.J, Gershon, R.C, Rymer, W.Z, Assessing dexterity function: a comparison of two alternatives for the NIH Toolbox, Journal of Hand Therapy, 2011, 24, 313-20.
• Smith, Y.A, Hong E, Presson C, Normative and validation studies of the Nine-hole Peg Test with children, Perceptual and Motor Skills, 2000, 90, 823-43.
• Jones, C.J, Rikli, R.E, Beam, W.C, A 30-s chair-stand test as a measure of lower body strength in community-residing older adults, Research Quarterly for Exercise and Sport, 1999, 70, 113-9.
• Voll, R, Krumm, B, Schweisthal, B, Functional independence measure (FIM) assessing outcome in medical rehabilitation of neurologically ill adolescents, International Journal of Rehabilitation Research, 2001, 24, 123-31.
• Küçükdeveci, A.A, Yavuzer, G, Elhan, A.H, Sonel, B, Tennant, A, Adaptation of the Functional Independence Measure for use in Turkey, Clinical Rehabilitation, 2001, 15, 311-9.
• Varni, J.W, Burwinkle, T.M, Katz, E.R, Meeske, K, Dickinson, P, The PedsQL in pediatric cancer: reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module, Cancer, 2002, 94, 2090-106.
• Yıldız Kabak, V, Yakut, Y, Çetin, M, Düger, T, Reliability and Validity of the Turkish Version of the PedsQL 3.0 Cancer Module for 2- to 7-Year-Old and the PedsQL 4.0 Generic Core Scales for 5- to 7-Year-Old: The Hacettepe University Experience, Turkish Journal of Haematology, 2016, 33, 236-43.
• Tan, S.Y, Poh, B.K, Chong, H.X, Ismail, M.N, Rahman, J, Zarina, A.L, Juraida AR, Tahir A, Ruzita AT, Roslee R, Shanita SN, et al., Physical activity of pediatric patients with acute leukemia undergoing induction or consolidation chemotherapy, Leukemia Research, 2013, 37, 14-20.
• Green, J.L, Knight, S.J, McCarthy, M, De Luca, C.R, Motor functioning during and following treatment with chemotherapy for pediatric acute lymphoblastic leukemia, Pediatric Blood & Cancer, 2013, 60, 1261-6.
• Ness, K.K, Kaste, S.C, Zhu, L, Pui, C.H, Jeha, S, Nathan, P.C, et al., Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia, Leukemia Lymphoma, 2015, 56, 1004-11.
• Akbaş, A.N, Uysal, M.F, Özengin, N, Akut lenfoblastik lenfomalı çocuklarda hospitalizasyon sürecinde kas iskelet sisteminin durumu, uyku ve yaşam kalitesi: tanımlayıcı pilot çalışma, Adnan Menderes Universitesi Sağlık Bilimleri Fakültesi Dergisi, 2018, 2, 31-38.
• Yildiz Kabak, V, Duger, T, Uckan Cetinkaya, D, Investigation of the Effects of an Exercise Program on Physical Functions and Activities of Daily Life in Pediatric Hematopoietic Stem Cell Transplantation, Pediatric Blood & Cancer, 2016, 63, 1643-8.
• Deisenroth, A, Söntgerath,, R, Schuster A.J, von Busch, C, Huber, G, Eckert, K, Kulozik, A.E, Wiskemann, J, Muscle strength and quality of life in patients with childhood cancer at early phase of primary treatment, Pediatric Hematology and Oncology, 2016, 33, 393-407.