Role of cytokine gene polymorphisms on ramipril-altered inflammatory response and myocardial injury in patients undergoing coronary artery bypass surgery

Meral Urhan Küçük; Kerem Karaca; Seyhan Şahan Fırat; Özden , Vezir; Necmiye Canacankatan; Barlas Naim Aytaçoğlu; Sema Erden; Bahar Tunçtan; Nehir Sucu

doi:10.17826/cutf.323386

TR EN

Koroner arter bypass cerrahisinde ramiprilin miyokardiyal hasar ve inflamatuvar yanıttaki etkisi üzerinde sitokin gen polimorfizmlerinin rolü

Öz

Amaç: Ramipril, inflamatuar miyokardial hasarın tedavisinde TNF-α, IL-6 ve IL-8 gibi sitokin seviyelerini azaltarak etkili olmaktadır. Çalışmamızda, ramipril tedavisinin, koroner arter bypass cerrahisi esnasında oluşan inflamatuar yanıt ve miyokardiyal hasara yönelik etkisi üzerinde, sitokin gen polimorfizmlerinin herhangi bir rolü olup olmadığını araştırdık.

Gereç ve Yöntem: Çalışmamıza, koroner arter bypass cerrahisi uygulanan hastalardan cerrahi öncesi ramipril alan 51, kontrol grubu olarak ise ramipril almayan 51 olmak üzere toplam 102 hasta dahil edildi. Her iki grupta, anestezi başlamadan hemen önce (t1), kros klemp sonrası 20. dakikada (t2), ameliyatın sonunda (t3) ve anestezinin başlangıcından 24 saat sonra (t4) alınan kan örneklerinden TNFα, IL-6, IL-8 ve TnT serum düzeyleri ELISA yöntemi ile, genotipleme ise PCR-RFLP yöntemleri ile belirlendi.

Bulgular: Her iki grupta TNF-α artışı cerrahi ile başlarken, IL-6 ve IL-8 artışı kardiyopulmoner bypass sırasında kardiyak arrestle başlayıp ameliyat sonuna kadar devam etmiştir. Postoperatif dönemde ise sadece IL-8 kontrol grubunda yüksek kalırken; çalışma grubunda TNF-α, IL-6, IL-8 düşüşe geçmektedir. t3 zaman aralığında IL-6, t4 zamanında TNFα değerlerinde anlamlı azalma gözlenmiştir.

Sonuç: Ramiprilin kardiyak arrest sonrası sitokin ve TnT düzeylerini azaltarak inflamatuar miyokardiyal hasarı önlemede yeri olabilir.

Anahtar Kelimeler

ACE inhibitörleri,sitokin,polimorfizm

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Meral Urhan Küçük

Kerem Karaca Bu kişi benim

Seyhan Şahan Fırat Bu kişi benim

Özden , Vezir Bu kişi benim

Necmiye Canacankatan Bu kişi benim

Barlas Naim Aytaçoğlu Bu kişi benim

Sema Erden Bu kişi benim

Bahar Tunçtan Bu kişi benim

Nehir Sucu Bu kişi benim

Yayımlanma Tarihi

30 Eylül 2017

Gönderilme Tarihi

20 Ağustos 2016

Kabul Tarihi

23 Eylül 2016

Yayımlandığı Sayı

Yıl 2017 Cilt: 42 Sayı: 3

DOI

https://doi.org/10.17826/cutf.323386

IZ

https://izlik.org/JA23WJ65DN

MLA

Küçük, Meral Urhan, vd. “Role of cytokine gene polymorphisms on ramipril-altered inflammatory response and myocardial injury in patients undergoing coronary artery bypass surgery”. Cukurova Medical Journal, c. 42, sy 3, Eylül 2017, ss. 436-45, doi:10.17826/cutf.323386.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Koroner arter bypass cerrahisinde ramiprilin miyokardiyal hasar ve inflamatuvar yanıttaki etkisi üzerinde sitokin gen polimorfizmlerinin rolü

Koroner arter bypass cerrahisinde ramiprilin miyokardiyal hasar ve inflamatuvar yanıttaki etkisi üzerinde sitokin gen polimorfizmlerinin rolü

Öz

Anahtar Kelimeler