Role of the Hereditary Thrombophilic Abnormalities in Retinal Vein Occlusions
Abstract
Purpose: The aim of our study was to evaluate the relation between hereditary thrombophilic factors leading to coagulation disorders and retinal vein occlusion (RVO). Material and Methods: A total of 45 consecutive patients with RVO group and 42 healty subjects (Control group) were enrolled. The mean follow-up period was 15.2±5.5 months. The following investigations were performed in both groups: Factor V Leiden (FVL), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) enzyme mutations, antithrombin III, protein C and S activities, fibrinogen, factor VII and VIII levels, D-dimer, activated partial thromboplastin time and prothrombin time/INR, complete blood count, ESR and blood biochemistry. Results: Factor V leiden heterozygote mutation was found in four (9%) patients in RVO and one (2.4%) in Control groups. Homozygote FVL mutation and PT G20210A mutation were not found in neither of the groups. In the RVO group, 26 patients (57.8%) had MTHFR C677T heterozygote mutation and four (8.9%) had homozygote mutation. In the Control group 14 (33.3%) patients had MTHFR C677T heterozygote mutation and four (9.5%) had homozygote mutation. There was a significant difference in MTHFR C677T genotype distribution between the 2 groups (p=0,032). The serum triglyceride, glucose, fibrinogen and ESR levels were significantly higher in patients compared to the controls Conclusion: We believe that, in addition to all related systemic and ophthalmological investigations, hematological screening tests to detect hypercoagulation should be performed while investigating the etiology in patients with RVO.
Keywords
Kaynakça
- Recchia FM, Brown GC. Systemic disorders associated with retinal vascular occlusion. Curr Opin Ophthalmol. 2000;11:462-7.
- Salomon O, Moissiev J, Rosenberg N, Vidne O, Yassur I, Zivelin A, et al. Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vascular occlusion. Blood Coagul Fibrinolysis. 1998;9:617-22.
- Albisinni R, Coppola A, Loffredo M, Cerbone AM, Di Minno G, Greco GM. Retinal vein occlusion and inherited conditions predisposing to thrombophilia. Thromb Haemos. 1998;80:702-3.
- Backhouse O, Parapia L, Mahomed I, Lee D. Familial thrombophilia and retinal vein occlusion. Eye. 2000;14:13-7.
- The Eye Disease Case-Control Study Group. Risk factors for central retinal vein occlusion. Arch Ophthalmol. 1996;114:545-54.
- The Eye Disease Case-Control Study Group. Risk factors for branch retinal vein occlusion. Am J Ophthalmol. 1993;116:286-96.
- Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64-7.
- Bowen DJ, Bowley S, John M, Collins PW. Factor V Leiden (G1691A), the prothrombin 3´-untranslated region variant (G20210A) and thermolabile methylenetetrahydrofolate reductase (C677T): a single genetic test genotypes all three loci. Determination of frequencies in the S. Wales population of the UK. Thromb Haemost. 1998;79:949-54.
- Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88:3698-703.
- Rosendaal FR, Doggen CJ, Zivelin A, Arruda VR, Aiach M, Siscovick DS, et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost. 1998;79:706-8.
