Investigation of effects of PALB2 genetic variations on breast cancer predisposition

Müge Yüksel Bilen; Mehmet Berköz; Ali Erdinç Yalın; Züleyha Çalıkuşu; Pelin Eroğlu; Ülkü Çömelekoğlu; Serap Yalın

doi:10.17826/cumj.634598

TR EN

Investigation of effects of PALB2 genetic variations on breast cancer predisposition

Abstract

Purpose: In this study, the effects of three different single nucleotide polymorphisms (rs249954, rs249935, and rs16940342) of partner and localizer of breast cancer gene 2 (PALB2) on breast cancer predisposition have been investigated.
Materials and Methods: For this purpose, 150 patients diagnosed to have breast cancer and 150 healthy individuals have been included. By using real time polymerase chain reaction (PCR) method isolated deoxyribonucleic acid (DNA) from each case has been investigated for the PALB2 genetic variations.
Results: The distribution of homozygote wild type (AA) and heterozygote (AG) genotypes at rs16940342 polymorphism has been observed to be 44.7% and 55.3% in breast cancer group and 32.7% and 67.3% in control group. The homozygote polymorphic (GG) genotype was not observed in both groups. The discrepancy between the groups in terms of genotype distribution regarding rs16940342 polymorphism has been found statistically significant. However, there was no significant difference in the frequencies of rs249954 and rs249935 polymorphisms comparing both groups.
Conclusion: These results show that rs16940342 polymorphism may be an important determinant in terms of breast cancer predisposition in the Turkish population.

Keywords

Breast cancer,genetic polymorphism,breast cancer gene 2

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Biyokimya ve Hücre Biyolojisi (Diğer)

Bölüm

Araştırma Makalesi

Yazarlar

Müge Yüksel Bilen Bu kişi benim
0000-0003-1840-8007
Türkiye

Mehmet Berköz
0000-0003-4219-8054

Ali Erdinç Yalın
0000-0002-3351-6885

Züleyha Çalıkuşu Bu kişi benim
0000-0003-0875-1485

Pelin Eroğlu Bu kişi benim
0000-0002-6462-6841

Ülkü Çömelekoğlu
0000-0001-8060-6333

Serap Yalın ^*
0000-0002-1286-2172

Yayımlanma Tarihi

31 Mart 2020

Gönderilme Tarihi

18 Ekim 2019

Kabul Tarihi

1 Ocak 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 45 Sayı: 1

DOI

https://doi.org/10.17826/cumj.634598

IZ

https://izlik.org/JA47CP47CF

MLA

Yüksel Bilen, Müge, vd. “Investigation of effects of PALB2 genetic variations on breast cancer predisposition”. Cukurova Medical Journal, c. 45, sy 1, Mart 2020, ss. 186-94, doi:10.17826/cumj.634598.

Cited By

Investigation of the germline PALB2 variants in cancer patients using the next-generation sequencing in Türkiye

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

https://doi.org/10.30569/adiyamansaglik.1378620

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Investigation of effects of PALB2 genetic variations on breast cancer predisposition

PALB2 genetik varyasyonlarının meme kanseri yatkınlığı üzerindeki etkilerinin araştırılması

Öz

Anahtar Kelimeler

Investigation of effects of PALB2 genetic variations on breast cancer predisposition

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Investigation of the germline PALB2 variants in cancer patients using the next-generation sequencing in Türkiye