Medulloblastoma in children: 84 patients from a single institution
Abstract
Purpose: Medulloblastoma is the most common malignant brain tumor in children. Current treatment strategy for medulloblastoma includes surgery, followed by radiotherapy and chemotherapy. In the present study, we analyze the clinical features, risk categories, treatment, and outcome of the patients with medulloblastoma treated in our institution in the last 15 years.
Materials and Methods: 84 patients with a diagnosis of medulloblastoma at our institution between January 2004 and December 2018 were included in the sudy. Hospital files of the patients were investigated and clinical and epidemiological characteristics, histopathology, treatment modalities, prognostic criteria and survival rates of patients were noted in data form.
Results: There were 45 males and 39 females with a median age of 8 years at the time of diagnosis. Approximately 12% of the patients were Syrian refugees. 54 patients were included in average-risk group and 30 in high-risk group based on the age at the time of diagnosis, extent of the residual tumor after surgery and Chang staging system. Five-year overall survival and event-free survival rates were 58.1% and 57.6% respectively. The prognostic factors having a statistically significant influence on survival were histopathological group, type of surgery and risk group. Only the risk group was found to have an impact on survival in multivariate analysis.
Conclusion: Risk group, utilizing the age of the patient, degree of surgical resection and metastatic disease, is the most important parameter having an impact on survival of patients with medulloblastoma.
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