The effect of thiol/disulfide homeostasis on chronic obstructive pulmonary disease-related mortality
Öz
Purpose: Our study investigates the correlation between thiol/disulfide homeostasis and mortality among chronic obstructive pulmonary disease (COPD) patients with hypercapnic respiratory failure (HRF).
Materials and Methods: This cross-sectional prospective study comprises a total of 104 subjects, including 64 HRF patients admitted to the Emergency service due to respiratory failure and 40 healthy controls. HRF patients were further divided into two subgroups as those in whom mortality occured after 1 month (n=14), and those who survied (n=50). Thiol/disulfide homeostasis was evaluated using a novel and automated assay developed by Erel and Neselioglu.
Results: The total thiol (TT) and native thiol (NT) levels were significantly lower in the HRF group than the control group, whereas the mean disulfide (Ds)/TT and Ds/NT values were significantly higher. The Ds levels were not significantly different between the groups. On the other hand, Ds, Ds/TT, and Ds/NT values of surviving HRF patients were significantly lower than those of the HRF patients who died. In this article we found that Ds may be an indicator of mortality in COPD (sensitivity: 85.7%, specificity: 70%, AUC: 0.793, 95% CI: 0.673-0.884, p<0.001).
Conclusion: Thiol/disulfide parameters may be used in emergency service and hospitals in the diagnosis of HRF, and for the prediction and improvement of prognosis.
Anahtar Kelimeler
Emergency service, hypercapnic respiratory failure, oxidative stress, thiol
Destekleyen Kurum
Yok
Proje Numarası
Proje değil
Teşekkür
Dr Yusuf Dursun'a katkılarından dolayı teşekkür ediyoruz
Kaynakça
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