Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital

Emine Nur Özdamar; İhsan Özdamar

doi:10.17826/cumj.865824

EN TR

Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital

Abstract

Purpose: The aim of the present study is to determine the frequency and severity of possible drug-drug interactions (DDIs) in the prescriptions of patients who admitted to the orthopedics and traumatology outpatient clinics. Materials and Methods: This cross-sectional, retrospective study analyzed the prescription data of patients that admitted to orthopedics and traumatology outpatient clinics of a tertiary care hospital from January 1, 2020 to February 15, 2020. The severity of DDIs was interpreted using the Lexi-comp® drug interaction database. Relationship between the presence of DDIs and the number of prescribed drugs were evaluated. Results: Out of 753 patient data evaluated, a total of 2248 drugs were prescribed. Among 669 polypharmacy patients, 293 (43.8%) patients had one or more potential DDIs. A total of 437 DDIs were detected of which 300 (68.6%) were D, 82 (18.8%) were X, 49 (11.2%) were C and 6 (1.4%) were B risk category interactions. The most common DDIs were between systemic Diclofenac and topical Diclofenac, (14.4%) The presence of potential DDIs was significantly associated with adult age and female gender. Conclusion: Although, the severity of the potential DDIs in orthopedics and traumatology outpatient clinics were generally moderate and manageable, it is crutial for physicians to be aware of the interactions between the most frequently prescribed drugs in orthopedics and traumatology outpatient clinics, monitor patients for the safe use of drugs.

Keywords

Drug interactions , polypharmacy , orthopedics

Üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin değerlendirilmesi

Öz

Amaç: Bu çalışmanın amacı, ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçetelerinde olası ilaç-ilaç etkileşimlerinin sıklığını ve şiddetini belirlemektir. Gereç ve Yöntem: Bu kesitsel retrospektif çalışma, 1 Ocak 2020- 15 Şubat 2020 tarihleri arasında üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçete verilerini analiz etti. İlaç-ilaç etkileşimlerinin şiddeti, Lexi-comp® ilaç etkileşimi veri tabanı kullanılarak yorumlandı. İlaç-ilaç etkileşimi varlığı ile reçetelenmiş ilaç sayısı arasındaki ilişki değerlendirildi. Bulgular: Değerlendirilen 753 hasta verisinde toplam 2248 ilaç reçete edildi. 669 polifarmasi hastasından, 293 (%43.8) hastanın bir veya daha fazla potansiyel ilaç- ilaç etkileşimi vardı. 300’ü (%68.6) D, 82’si (%18.8) X, 49’u (%11.2) C ve 6’sı (%1.4) B risk kategorisi etkileşimleri olmak üzere toplam 437 ilaç-ilaç etkileşimi tespit edildi. En sık ilaç- ilaç etkileşimleri sistemik diklofenak ve topical diklofenak arasındaydı (%14.4). Olası ilaç-ilaç etkileşimlerinin varlığı erişkin yaş ve kadın cinsiyet ile anlamlı olarak ilişkiliydi. Sonuç: Ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin şiddeti genel olarak orta düzeyde ve yönetilebilir olsa da, ortopedi ve travmatoloji polikliniklerinde en sık reçete edilen ilaçlar arasındaki etkileşimlerden haberdar olmak ve ilaçların güvenli kullanımı için hastaları izlemek hekimler açısından önem taşımaktadır.

Anahtar Kelimeler

İlaç etkileşimleri , polifarmasi , ortopedi

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Emine Nur Özdamar ^*
0000-0003-0612-9000
Türkiye

İhsan Özdamar Bu kişi benim
0000-0002-0685-9284
Türkiye

Yayımlanma Tarihi

30 Haziran 2021

Gönderilme Tarihi

27 Ocak 2021

Kabul Tarihi

16 Mart 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 46 Sayı: 2

DOI

https://doi.org/10.17826/cumj.865824

IZ

https://izlik.org/JA57BN79HY

MLA

Özdamar, Emine Nur, ve İhsan Özdamar. “Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital”. Cukurova Medical Journal, c. 46, sy 2, Haziran 2021, ss. 601-9, doi:10.17826/cumj.865824.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital

Abstract

Keywords

Üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin değerlendirilmesi

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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