Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats

Yıl 2020, Cilt: 45 Sayı: 1, 251 - 256, 31.03.2020

Neslihan Pınar , Yusuf Karataş Yusuf Kenan Dağlıoğlu Gülfiliz Gönlüşen

https://doi.org/10.17826/cumj.648050

Cited By: 2

Öz

Purpose: We investigated the effects of Quercetin and Coenzyme Q10 antioxidant, on gentamicin-induced renal failure in rats.
Materials and Methods: The rats were given gentamicin (100 mg/kg/day, i.m., once a day), gentamicin (100 mg/kg/day, i.m.once a day) + Quercetin (15 mg/kg i.p. once a day) and gentamicin (100 mg/kg/day, i.m.) + Coenzyme Q10 (8 mg/kg i.m. once a day).
Results: In control the BUN value was 26.8 ± 0.8 (mg/100 mL); whereas, it was 117.3 ± 15.4 in gentamicin group. Renal histopathologic examination confirmed acute tubular necrosis in this group. In rats treated with gentamicin + Quercetin and gentamicin + Coenzyme Q10, a partial improvement in biochemical and histologic parameters was observed. BUN values were 117.3 ± 15.4, 44.0 ± 8.3, 47.8 ± 13.8 in gentamicin, gentamicin plus Quercetin and gentamicin plus Coenzyme Q10 treated groups, respectively. Creatinine values were 4.3 ± 0.6, 0.8 ± 0.1, 1.5 ± 0.4 in gentamicin, gentamicin plus Quercetin and gentamicin plus Coenzyme Q10 treated groups, respectively.
Conclusion: These results suggest that the administration of Quercetin and Coenzyme Q10 may have a protective effect on gentamicin-induced nephrotoxicity in rats.

Destekleyen Kurum

Çukurova Üniversitesi

Proje Numarası

2006/BAP 31

Teşekkür

Acknowledgements: Çukurova University Research Foundation TF/2006/BAP 31

Quercetin ve Koenzim Q10'un sıçanlarda gentamisin kaynaklı nefrotoksisite üzerine etkileri

Öz

Purpose: We investigated the effects of Quercetin and Coenzyme Q10 antioxidant, on gentamicin-induced renal failure in rats.
Amaç: Gentamisinle böbrek yetmezliği oluşturulan sıçanlarda Quercetin ve CoQ10 nun antioksidan etkilerini araştırmak amaçlanmıştır.
Gereç ve Yöntem: Sıçanlara gentamicin (100 mg/kg/day, i.m., günde 1 kez), gentamicin (100 mg/kg/day, i.m.) + Quercetin (15 mg/kg i.p. günde 1 kez) and gentamicin (100 mg/kg/day, i.m.) + CoQ10 (8 mg/kg i.m. günde 1 kez) uygulandı.
Bulgular: Kontrol grubundaki BUN değeri 26.8 ± 0.8 (mg/100 mL); buna karşın gentamisin grubunda 117.3 ± 15.4 bulunmuştur. Böbrek histopatolojik inceleme, bu grupta akut tübüler nekrozu doğruladı. Gentamicin + Quercetin ve gentamicin + CoQ10 uygulanan sıçanlarda biyokimyasal ve histolojik parametrelerde kısmi iyileşme gözlemlenmiştir. BUN değerleri gentamisin, gentamisin + Quercetin and gentamisin + CoQ10 gruplarında sırasıyla 117.3 ± 15.4, 44.0 ± 8.3, 47.8 ± 13.8 bulunmuştur. Gentamisin ile aralarında anlamlı farklılık bulunmuştur. Kreatinin değerleri gentamisin, gentamisin + Quercetin ve gentamisin + Koenzim Q10 ile tedavi edilen gruplarda sırasıyla 4.3 ± 0.6, 0.8 ± 0.1, 1.5 ± 0.4 idi.
Sonuç: Bu sonuçlar Quercetin ve CoQ10 uygulanmasının gentamisinle nefrotoksisite oluşturulan sıçanlarda koruyucu etkisi olduğunu göstermiştir. 

Anahtar Kelimeler

Gentamicin, nephrotoxicity, Coenzyme Q10

Proje Numarası

2006/BAP 31

Kaynakça

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