Pregnancy outcomes of patients with rheumatoid arthritis

Yıl 2020, Cilt: 45 Sayı: 2, 518 - 525, 30.06.2020

Erdem Fadıloğlu Canan Unal Atakan Tanacan M.sinan Beksac

https://doi.org/10.17826/cumj.664235

Öz

Purpose: The aim of this studywas to evaluate the obstetric outcomes of women with rheumatoid arthritis (RA)
Materials and Methods: This retrospective study consisted of 39 women with RA. Patients were evaluated in terms of seropositivity, having disease >5 years or not and use of any medication.
Results: Rate of preterm delivery and intrauterine growth retardation was 33.3% and 21.2%, respectively. Comparisons between seropositive and seronegative women did not show any significant difference. Having disease more or less than 5 years did not show any significant difference in terms of obstetric outcomes. Women with a coexisting disease had a similar rate of miscarriage rate compared to remainders (16.6% vs 14.8%). Women followed up without any medication has also higher rates of miscarriage despite lack of statistical significance.
Conclusion: Pregnancies of women with RA must be considered as high risk due to increased rates of adverse pregnancy outcomes such as preterm delivery and intrauterine growth retardation. 

Anahtar Kelimeler

Pregnancy, rheumatoid arthritis, obstetric outcome, miscarriage, preterm delivery, intrauterine growth retardation, seropositivity

Romatoid artrit hastalarının gebelik sonuçları

Öz

Amaç: Bu çalışmanın amacı romatoid Artrit (RA) hastalarının gebelik sonuçlarını değerlendirmektir.
Gereç ve Yöntem: Retrospektif planlanan çalışmamız 39 hastadan oluşmaktadır. Hastalar seropozitivite, hastalık süresinin 5 yıldan uzun olması ve ilaç kullanımı açısından değerlendirildiler.
Bulgular: Preterm doğum ve intrauterin gelişme geriliği oranı sırasıyla 33.3% ve 21.2% olarak bulundu. Seropozitif ve seronegatif hastalara ilişkin yapılan karşılaştırmalarda anlamlı fark izlenmedi. Hastalığın 5 yıldan uzun süredir olması ya da olmamasının da gebelik sonuçlarına etki etmediği görüldü. Ek bir hastalığı olanlarda ise diğer hastalarda benzer oranda düşük izlendi (%16.6, %14.8). İlaçsız olarak izlenen hastalarda ise istatistiksel farklılık olmamasına rağmen daha yüksek oranda düşük izlendi.
Sonuç: RA tanısı olan gebeliklerin preterm doğum ya da intrauterin gelişme geriliği gibi komplikasyonların daha sık izlenmesi nedeniyle yüksek riskli gebelikler olarak değerlendirilmesi gerekmektedir.

Anahtar Kelimeler

romatoid artrit, gebelik, obstetrik sonuç, düşük, preterm doğum, intrauterin gelişme geriliği, seropozitivite

Kaynakça

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