Premenapozal migren hastalarında aort sertliği parametrelerinin değerlendirilmesi

Yıl 2020, Cilt: 45 Sayı: 2, 511 - 517, 30.06.2020

Ertuğrul Emre Güntürk , Selçuk Doğan Ayşe Nur Topuz

https://doi.org/10.17826/cumj.701497

Öz

Amaç: Migren, ağırlıklı olarak kadınlar olmak üzere yetişkin nüfusun yaklaşık %10’unu etkileyen epizodik birincil baş ağrısı bozukluğudur. Migrende tespit edilen değişikliklere ve önceki bulgulara dayanarak, arteriyel sertliğin migren hastalarında vasküler olaylara önemli bir katkıda bulunduğu düşünülebilir. Bu çalışmanın amacı, premenapozal migren hastalarında aort sertliğinin değerlendirilmesi ile ateroskleroz ve migren arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntem: Çalışmaya migreni olan 68 premenapozal kadın hasta ve 39 sağlıklı kadın kontrol grubu olarak dahil edildi. Migren ve arteriyel sertlik arasındaki ilişkiyi ortaya çıkarmak için tüm katılımcılara ekokardiyografi uygulandı ve aort sertlikleri değerlendirildi. Katılımcıların kan basıncı ölçümleri, temel biyokimyasal testleri ve 12 derivasyon EKG kayıtları eşzamanlı alındı.
Bulgular: Temel ekokardiyografik bulgular hasta ve kontrol grubunda benzerdi. Aortun sistolik ve diastolik çapları, aort çapındaki değişim oranları her iki grupta benzerdi. Auralı ve aurasız migrenli hastalar ve kontrol grupları arasında sistolik, diastolik ve nabız basınçları açısından anlamlı farklılık tespit edilmedi.
Sonuç: Aterosklerozun bir belirteci olarak aort sertliği parametreleri Migren hastaları ile kontrol grubu arasında farklı değildir.

Anahtar Kelimeler

Migraine, Arterial stiffness

Destekleyen Kurum

yok

Evaluation of aortic stiffness parameters in premenopausal migraine patients

Öz

Purpose: Migraine is an episodic primary headache disorder, which affects approximately 10% of the adult population, predominantly females. Based on the changes detected in migraine and previous findings, arterial stiffness can be considered to be an important contributor to vascular events in patients with migraine. The aim of this study was to investigate the associations between atherosclerosis and migraine through the evaluation of aortic stiffness in premenopausal migraine patients.
Materials and Methods: The study included 68 female patients with migraine, and a control group of 39 healthy females. To reveal the association between migraine and arterial stiffness, echocardiography was applied and aortic stiffness was evaluated. Blood pressure measurements, basic biochemical tests and the 12 derivation-ECG recordings of each patient were taken simultaneously.
Results: Basic echocardiographic findings were similar in patients and the control group. Systolic and diastolic diameters of the aorta, and the change in aortic diameter were also similar in both groups. Aortic distensibility, aortic strain and beta indices were also similar in both groups. No significant differences were determined between patients with and without aura migraine and the control group in respect of systolic blood pressure, diastolic blood pressure and pulse pressure.
Conclusion: As a marker of atherosclerosis, the aortic stiffness parameters didn’t differ between migraine and control group.

Anahtar Kelimeler

Migraine, arterial stiffness

Kaynakça

• References 1. Stovner Lj, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, Steiner T, Zwart JA: The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27, 193-210 (2007) 2. Leroux E, Ducros A: Cluster headache. Orphanet J Rare Dis 3, 20 (2008) 3. Olesen J and Leonardi M: The burden of brain diseases in Europe. Eur J Neurol 10, 471–477 (2003) 4. Celentano DP, Stewart WF, Linet MS: The reationship of headachesymptoms with severty and duration of attacks. J Clin Epidemiol 1, 113 (1990) 5. Hamed SA: The vascular risk associations with migraine:relation to migraine susceptibility and progression. Atherosclerosis 205, 15-22 (2009) 6. Goadsby PJ, Lipton RB , Ferrari MD: Migraine – current understanding and treatment . N Engl J Med 346, 257-270 (2002) 7. Vlachopoulos C, Aznaouridis K , Stefanadis C: Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis . J Am Coll Cardiol 55, 1318-1327 (2010) 8. Zieman SJ , Melenovsky V , Kass D A: Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 25, 932-943 (2005) 9. Laurent S, Boutouyrie P: Recent advances in arterial stiffness and wave reflection in human hypertension. Hypertension 49, 1202-1206 (2007) 10. Safar ME , Levy BI, Struijker-Boudier H: Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation 107, 2864-2869 (2003) 11. Tietjen GE: Migraine as a systemic vasculopathy. Cephalalgia 2, 989-996 (2009) 12. Silberstein SD: Migraine pathophysiology and its clinical implications. Cephalalgia 24 Suppl 2, 2-7 (2004) 13. de Hoon JN , Willigers JM , Troost J, Struijker-Boudier HA, van Bortel LM: Cranial and peripheral interictal vascular changes in migraine patients . Cephalalgia 23, 96-104 (2003). 14. Nagai T, Tabara Y , Igase M , Nakura J, Miki T, Kohara K: Migraine is associated with enhanced arterial stiffness. Hypertens Res 30, 577-583 (2007) 15. Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB: Migraine and cardiovascular disease: a population-based study. Neurology 74, 628-635 (2010) 16. Schurks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T: Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 339, b3914 (2009) 17. Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S: Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med 123, 612-624 (2010) 18. Akazawa Y, Motoki N, Tada A, Yamazaki S, Hachiya A, Matsuzaki S, Kamiya M, Nakamura T, Kosho T, Inaba Y: Decreased Aortic Elasticity in Children With Marfan Syndrome or Loeys-Dietz Syndrome. Circ J 80, 2369-2375 (2016) 19. Çekiç EG, Başaran Ö, Filiz Başaran N, Elmas O, Doğan V, Mert GÖ, Mert KU, Altun I, Akın F, Biteker M: Cutaneous microvascular reactivity and aortic elasticity in coronary artery disease: Comparison of the laser Doppler flowmetry and echocardiography. Microvasc Res 109, 19-25 (2017) 20. Jia CF, Jiang YN, Yang ZQ, Sun XX, Yu Y, Wang H, Lu Y, Chen AJ, Wang ZQ: Ascending Aortic Elasticity and Related Risk Factors Study on Prehypertension Patients. Am J Hypertens 30, 61-66 (2017) 21. Aslan AN, Sarı C, Özer Sarı S, Tayfur Yürekli Ö, Baştuğ S, Sivri S, Ersoy O, Bozkurt E: Association between aortic stiffness and left ventricular function in inflammatory bowel disease. Cardiol J 23, 202-210 (2016) 22. Wang W, Guo W, Liu XP, Jia X, Zhang HP, Zhang MH, Du X: Study of ascending aortic elasticity in the Chinese population with a high risk of aortic diseases. Int J Clin Exp Med 8, 3381-3390 (2015) 23. Akturk F, Erturk M, Topcular B, Altinkaya A, Behrem N, Gul G, Orten M, Yalcin AA, Uzun F: Impaired aortic elastic properties in young females with migraine. Ideggyogy Sz 67, 201-204 (2014) 24. Yetkin E , Ozisik H, Ozcan C, Aksoy Y, Turhan H: Decreased endothelium-dependent vasodilatation in patients with migraine: a new aspect to vascular pathophysiology of migraine. Coron Artery Dis 17, 29-33 (2006) 25. Yetkin E , Ozisik H, Ozcan C, Aksoy Y, Turhan H: Increased dilator response to nitrate and decreased fl ow-mediated dilatation in migraineurs. Headache 47, 104 -110 (2007) 26. Scher AI, Terwindt GM, Picavet HS , V erschuren WM , Ferrari MD , Launer LJ: Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64, 614-620 (2005) 27. Tomiyama H, Yamashina A: Non-invasive vascular function tests: Their pathophysiological background and clinical application. Circ J 74, 24-33 (2010) 28. Kalil GZ, Recober A, Hoang-Tienor A, Bridget Zimmerman M, Haynes WG, Pierce GL: Higher augmentation index is associated with tension type headache and migraine in middle aged/older humans with obesity. Obesity (Silver Spring) 24, 865-870 (2016). 29. Schillaci G, Sarchielli P, Corbelli I, Pucci G, Settimi L, Mannarino MR, Calabresi P, Mannarino E: Aortic stiffness and pulse wave reflection in young subjects with migraine: a case-control study. Neurology 75, 960-966 (2010). 30. Dogan A, Orscelik O, Kocyigit M, Elcik D, Baran O, Cerit N, Inanc MT, Kalay N, Ismailogullari S, Saka T, Ozdogru I, Oguzhan A, Eryol NK: The effect of prophylactic migraine treatment on arterial stiffness. Blood Press 24, 222-229 (2015) 31. Ikeda K, Hirayama T, Iwamoto K, Takazawa T, Kawase Y, Yoshii Y, Kano O, Kawabe K, Tamura M, Iwasaki Y: Pulse wave velocity study in middle-aged migraineurs at low cardiovascular disease risk. Headache 51, 1239-1244 (2011)