Anxiety sensitivity in bipolar disorder and schizophrenia

Year 2020, Volume: 45 Issue: 2, 721 - 730, 30.06.2020

Zeynep Namlı , Lut Tamam , Mehmet Emin Demirkol , Soner Çakmak

https://doi.org/10.17826/cumj.723876

Abstract

Purpose: This study investigated the relationship between the clinical and sociodemographic characteristics of patients with bipolar disorder and schizophrenia and the levels of anxiety sensitivity.
Materials and Methods: Fifty-nine patients (33 females, 26 males) with bipolar disorder in the euthymic period without any comorbid mental disorders between the ages of 18-65 and 65 (28 females, 37 males) clinically stable patients with schizophrenia, and 88 (47 females, 41 males) healthy volunteer consist the sample group of the study. Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS) were applied for patients with bipolar disorder, Positive and Negative Syndrome Scale (PANSS) for patients with schizophrenia and Anxiety Sensitivity Index-3 (ASI-3) to the whole sample group.
Results: ASI-3 total, cognitive, and social subscale scores were significantly higher in patients with bipolar disorder and schizophrenia compared to the control group. Patients with bipolar disorder who had previous suicide attempts had significantly higher ASI-3 physical and total scores than those who did not attempt suicide. There was a significant linear correlation between physical, cognitive, and total scores of ASI-3 and PANSS positive scores of patients with schizophrenia.
Conclusion: Anxiety sensitivity is higher in patients diagnosed with bipolar disorder and schizophrenia compared to healthy individuals. This study revealed that anxiety sensitivity is a predictor of previous suicide attempts in bipolar disorder, and in schizophrenia, it is associated with disorder severity, particularly with positive psychotic symptoms.

Keywords

nxiety sensitivity, bipolar disorder, schizophrenia

Project Number

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Bipolar bozukluk ve şizofrenide anksiyete duyarlılığı

Abstract

Amaç: Bu çalışmada bipolar bozukluk ve şizofreni tanılı hastaların klinik ve sosyodemografik özelliklerinin anksiyete duyarlılığı ile ilişkisi incelenmiştir.

Gereç ve Yöntem: Çalışmanın örneklem grubunu 18-65 yaş aralığında, komorbid ruhsal hastalığı bulunmayan ötimik dönemde olan 59 (33 kadın, 26 erkek) bipolar bozukluk ve klinik olarak stabil 65 (28 kadın, 37 erkek) şizofreni tanılı hasta, 88 (47 kadın, 41 erkek) sağlıklı gönüllü oluşturmaktadır. Bipolar bozukluk tanılı hastalara Young Mani Derecelendirme Ölçeği (YMDÖ), Hamilton Depresyon Derecelendirme Ölçeği (HAM-D), şizofreni tanılı hastalara Pozitif ve Negatif Sendrom Ölçeği (PANSS) ve tüm örneklem grubuna Anksiyete Duyarlılığı İndeksi-3 (ADİ-3) uygulanmıştır.

Bulgular: ADİ-3 toplam, bilişsel ve sosyal alt boyut puanı bipolar bozukluk ve şizofreni tanılı hastalarda kontrol grubuna göre anlamlı ölçüde yüksek saptanmıştır. Geçmişte özkıyım girişiminde bulunan bipolar bozukluk tanılı hastaların ADİ-3 fiziksel ve toplam puanlarının özkıyım girişiminde bulunmayanlara göre anlamlı düzeyde yüksek olduğu belirlenmiştir. Şizofreni tanılı hastaların ADİ-3 fiziksel, bilişsel ve toplam puanları ile PANSS pozitif puanları arasında anlamlı düzeyde doğrusal bir ilişki saptanmıştır.

Sonuç: Anksiyete duyarlılığı bipolar bozukluk ve şizofreni tanılı hastalarda sağlıklı kişilere göre yüksektir. Çalışma verilerinden anksiyete duyarlılığının bipolar bozuklukta geçmiş özkıyım girişimleri için yordayıcı olduğu, şizofrenide ise hastalık şiddetiyle özellikle pozitif psikotik belirtilerle ilişkili olduğu sonucuna varılabilir.

Keywords

bipolar bozukluk, şizofreni, anksiyete duyarlılığı, özkıyım

Supporting Institution

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Project Number

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Thanks

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