Trigliserit-glukoz aterojenik prediktör indeksi ile santral retinal arter oklüzyonu arasındaki ilişki

Yıl 2024, Cilt: 49 Sayı: 3, 696 - 702, 30.09.2024

Zeynep Katipoğlu , Meydan Turan

https://doi.org/10.17826/cumj.1492273

Öz

Amaç: Santral retinal arter tıkanıklığı (CRAO), ciddi görme kaybına neden olan akut bir iskemik olaydır ve daha ileri serebrovasküler ve kardiyovasküler olayların habercisidir. Trigliserid-glikoz indeksi (TyG), sağlıklı bireylerde insülin direncini gösterir. Çok sayıda araştırma, TyG indeksini metabolik sendrom, hipertansiyon ve yeni başlayan diyabetle ilişkilendirir. Son araştırmalar ayrıca, kardiyovasküler hastalıklarda ateroskleroz belirtisi olarak rolünü ve vasküler hasarı değerlendirmede potansiyel klinik önemi olduğunu ileri sürmektedir. Bu çalışmada, CRAO ve TyG indeksi arasındaki ilişki değerlendirilmiştir.
Gereç ve Yöntem: Bu vaka kontrol çalışmasına Ocak 2018'den Mart 2023'e kadar hastanemizde 116 yetişkin (50 CRAO hastası ve kronik göz hastalığı olmayan 66 kontrol deneği) katılmıştır. TyG indeksi ln[açlık TG (mg/dL) × açlık plazma glikozu (mg/dL)/2] olarak formüle edilmiştir.
Bulgular: CRAO grubunun ortalama yaşı 65,0±14,7 yıldı ve 27 (%55,1 54) kadın vardı. Kontrol grubunun ortalama yaşı 61,2±12,1 yıldı ve 32 (%48,5) kadın vardı. Ortalama TyG indeksi CRAO grubunda 9,05±0,7 ve kontrollerde 8,7±0,7 idi ve istatistiksel olarak anlamlı bir farktı. Tek değişkenli regresyon analizi, TyG indeksi ve CRAO arasında bir ilişki olduğunu gösterdi (OR=2,04; CI: 1,11-3,73). Bu ilişki, çok değişkenli lojistik regresyon analizinde anlamlılığını korudu (OR=1,88; CI: 1,01-3,50).
Sonuç: Bu çalışma, aterojenik bir gösterge olan TyG indeksinin CRAO hastalarında kontrollerle karşılaştırıldığında anlamlı derecede daha yüksek olduğunu saptadık.

Anahtar Kelimeler

Santral retinal arter tıkanıklığı, retina, trigliserid-glukoz indeksi, vaskuler hastalık

The association between triglyceride-glucose atherogenic predictor index and central retinal artery occlusion

Öz

Purpose: Central retinal artery occlusion (CRAO) is an acute ischemic event causing severe visual loss and is a precursor to further cerebrovascular and cardiovascular events. The triglyceride-glucose index (TyG) indicates insulin resistance in healthy individuals. Numerous research links the TyG index to metabolic syndrome, hypertension, and new-onset diabetes. Recent research also suggests its role as a sign of atherosclerosis in cardiovascular diseases, with potential clinical significance in assessing vascular damage. In this study, the relationship between CRAO and TyG index was evaluated.
Materials and Methods: This case-control study involved 116 adults (50 CRAO patients and 66 control subjects without chronic eye diseases) at our hospital from January 2018 to March 2023. The TyG index was formulated as ln[fasting TG (mg/dL) × fasting plasma glucose (mg/dL)/2].
Results: The CRAO group had a mean age of 65.0±14.7 years, with 27 (55.1 % 54) females. The control group had a mean age of 61.2±12.1 years, with 32 (48.5) females. The mean TyG index was 9.05±0.7 in the CRAO group and 8.7±0.7 in controls, a statistically significant difference. Univariate regression analysis showed an association between the TyG index and CRAO (OR=2.04; CI: 1.11-3.73). This association remained significant in multivariate logistic regression analysis (OR=1.88; CI: 1.01-3.50).
Conclusion: This study found a significantly higher mean TyG index, an atherogenic indicator, in CRAO patients compared to controls.

Anahtar Kelimeler

Atherosclerosis, Central retinal artery occlusion, Retina, Triglyceride-glucose index, Vascular disease

Kaynakça

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