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Yıl 2022, Cilt: 32 Sayı: 2, 181 - 184, 17.04.2022
https://doi.org/10.17567/ataunidfd.933154

Öz

Kaynakça

  • 1. Atik A, Gümüş T. Propolisin gıda endüstrisinde kullanım olanakları. Akademik Gıda. 2017;15(1):60-65. [Crossref]
  • 2. Kasiotis K.M, Anastasiadou P, Papadopoulos A, Machera K. Revisiting Greek propolis: chromatographic analysis and antioxidant activity study. PloS One. 2017;12(1):e0170077. [Crossref]
  • 3. Abd-El-Rhman AMM. Antagonism of Aeromonas hydrophila by propolis and its effect on the performance of Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunol. 2009;27(3):454-459. [Crossref]
  • 4. Ghisalberti E. Propolis: A review. Bee World. 1979;60:59-84. [Crossref]
  • 5. Tezcan C. Propolisin kimyasal fiziksel ve biyolojik özellikleri tıpta kullanım alanları. Yüksek Lisans Tezi, Trakya Üniversitesi Fen Bilimleri Enstitüsü, Tekirdağ, 2000.
  • 6. Schmidt J.O. Bee products, chemical composition and application. In: Mirzahi A. Lensky Y. Bee products, properties, applications and apitherapy. New York; Plenum Press, 1996; 15: 16-21. [Crossref]
  • 7. Bankova V, Decastro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie. 2001;31(1):3-15. [Crossref]
  • 8. Cirasino L, Pisati A, Fasani F. Contact dermatitis from propolis. Contact Dermatitis. 1987;16(2):110-111. [Crossref]
  • 9. Monti M, Berti E, Carminati G, Cusini M. Occupational and cosmetic dermatitis from propolis. Contact Dermatitis. 1983;9(2):163. [Crossref]
  • 10. Libério SA, Pereira AL, Araújo MJ, et al. The potential use of propolis as a cariostatic agent and its actions on mutans group streptococci. J Ethnopharmacol. 2009;125(1):1-9. [Crossref]
  • 11. Ozan F, Sümer Z, Polat ZA, Er K, Ozan U, Deger O. Effect of mouth rinse containing propolis on oral microorganisms and human gingival fibroblast. Eur J Dent. 2007;1(4):195-201. [Crossref]
  • 12. Seidel V, Peyfoon E, Watson DG, Fearnley J. Comparative study of the antibacterial activity of propolis from different geographical and climatic zones. Phytother Res. 2008;22(9):1256-1263. [Crossref]
  • 13. Ferreres FMC, García-Viguera C, Bankova VS, De Castro SL, Dantas AP. Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol. 2001;74(2):105-112. [Crossref]
  • 14. Cook NC, Samman S. Flavonoids-Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem. 1996;7:66-76. [Crossref]
  • 15. Burdock G.A. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 1998;36(4):347-363. [Crossref]
  • 16. Çakıroğlu, T.N. Çeşitli çözücülerde Türk propolisinin çözünürlüğünün incelenmesi. Yüksek Lisans Tezi. Karadeniz Teknik Üniversitesi, Sağlık Bilimleri Enstitüsü, Trabzon 2010.
  • 17. Takeuchi TM, Pereira CG, Braga MEM, Marostica MR, Leal PF, Meireles MAA. Low pressure solvent extraction, microwave assisted, and ultrasound from condimentary plant. In: Extracting Bioactive Compounds for Food Products. CRC Press 2008;137-218. [Crossref]
  • 18. Marcucci MC. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie. 1995;26(2):83-99. [Crossref]
  • 19. Castaldo S, Capasso F. Propolis, an old remedy used in modern medicine. Fitoterapia. 2002;73(Suppl 1):S1-S6. [Crossref]
  • 20. Saarnio AS, Julkenen TR. Phenolic compounds of propolisfrom the boreal coniferous zone. J Apicult Sci. 2012;56(1):13-22. [Crossref]
  • 21. Nirala SK, Bhadauria M. Propolis reverses acetaminophen induced acute hepatorenal alterations: A biochemical and histopathological approach. Arch Pharm Res. 2008;31(4):451-461. [Crossref]
  • 22. Tatefuji T, Izumi N, Ohta T, Arai S, Ikeda M, Kurimoto M. Isolation and identification of compounds from Brazilian propolis which enhance macrophage spreading and mobility. Biol Pharm Bull. 1996;19(7):966-970. [Crossref]
  • 23. Wade C, Friedrich JA, New Canaan CT. Keats; Propolis power plus: the health-promoting properties of the amazing beehive energizer 1996.
  • 24. Koo H, Gomes BP, Rosalen PL, Ambrosano GM, Park YK, Cury JA. In vitro antimicrobial activity of propolis and Arnica Montana against oral pathogens. Arch Oral Biol. 2000;45(2):141-148. [Crossref]
  • 25. Madarova L. Antibacterial properties of propolis. Ceskoslovenska Stomatologie. 1980;80:304-307.
  • 26. Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol. 1999;64(3):235-240. [Crossref]
  • 27. Ferreira FB, Torres SA, Rosa OP, Ferreira CM, Garcia RB, Marcucci MC, Antimicrobial effect of propolis and other substances against selected endodontic pathogens. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(5):709-716. [Crossref]
  • 28. Kuştarcı Y, Sümer P, Kaya A. In vitro antimicrobial activity of propolis samples from three different regions of Anatolia. Curr Res Dent Sci. 2011;21(2):82-87.
  • 29. Ikeno K, Ikeno T, Miyazawa C. Effects of propolis on dental caries in rats. Caries Res. 1991;25(5):347-351. [Crossref]
  • 30. Koru O, Toksoy F, Acikel CH, et al. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. Anaerobe. 2007;13(3):140-145. [Crossref]
  • 31. Duarte S, Rosalen PL, Hayacibara MF, et al. The influence of a novel propolis on mutans streptococci biofilms and caries development in rats. Arch Oral Biol. 2006;51(1):15-22. [Crossref]
  • 32. Cardoso JG, Iorio NLP, Rodrigues LF, et al. Influence of a Brazilian wild green propolis on the enamel mineral loss and Streptococcus mutans’ count in dental biofilm. Arch Oral Biol. 2016;65:77-81. [Crossref]
  • 33. Nam S, Choi Y, Jang S, Shim Y, Han G. Antimicrobial activity of propolis on different oral bacteria. Indian J Sci Tech. 2016;9:1-4. [Crossref]
  • 34. Lin P, Cheng Y, Chu C, Chien K, Lin C, Tu Y. In-office treatment for dentin hypersensitivity: A systematic review and network meta-analysis. J Clin Periodontol. 2013;40(1):53-64. [Crossref]
  • 35. Sales-Peres SH, Carvalho FN, Marsicano JA. Effect of propolis gel on the in vitro reduction of dentin permeability. J Appl Oral Sci. 2011;19(4):318-323. [Crossref]
  • 36. Hussain RA, Dannan A, Al-Ahmad M. Propolis treatment for dental sensitivity after tooth bleaching. Imperial J Interdisciplinary Res. 2017;2:1436-1439.
  • 37. Toker H, Özan F, Özdemir H, Değer O. Dentin hassasiyetinin tedavisinde propolisin etkisi. Gazi Üni Diş Hek Fak Derg. 2008;25(3):1-6.
  • 38. Madhavan S, Nayak M, Shenoy A, Shetty R, Prasad K. Dentinal hypersensitivity: A comparative clinical evaluation of CPP-ACP F, sodium fluoride, propolis, and placebo. J Concerv Dent. 2012;15(4):315-318. [Crossref]
  • 39. Park YK, Alencar SM, Aguiar CL. Botanical origin and chemical composition of Brazilian propolis. J Agric Food Chem. 2002;50(9):2502-2506. [Crossref]
  • 40. Sabir A. The healing actions of propolis on direct pulp capping treatment: A review. J Dentomax Sci. 2016;1:186. [Crossref]
  • 41. Ramos A, Miranda J. Propolis: A review of its antiinflammatory and healing actions. J Ven Animal Toxins Inc Trop Dis. 2007;13(4):697-710. [Crossref]
  • 42. Coutinho A. Honeybee propolis extract in periodontal treatment: A clinical and microbiological study of propolis in periodontal treatment. Indian J Dent Res. 2012;23(2):294. [Crossref]
  • 43. Parolia A, Thomas M.S, Kundabala M, Mohan M. Propolis and its potential uses in oral health. Int J Med Med Sci. 2010;2:210-5.
  • 44. Feres M, Figueiredo LC, Barreto IM, Coelho MH, Araujo MW, Cortelli SC. In vitro antimicrobial activity of plant extracts and propolis in saliva samples of healthy and periodontally-involved subjects. J Int Acad Periodontol. 2005;7(3):90-96.
  • 45. Gebaraa EC, Pustiglioni AN, de Lima LA, Mayer MP. Propolis extract as an adjuvant to periodontal treatment. Oral Health Prev Dent. 2003;1(1):29-35.
  • 46. Koo H, Cury JA, Rosalen PL, Ambrosano GM, Ikegaki M, Park YK. Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation. Caries Res. 2002;36(6):445-448. [Crossref]
  • 47. Murray MC, Worthington HV, Blinkhorn AS. A study to investigate the effect of a propolis-containing mouthrinse on the inhibition of de novo plaque formation. J Clin Periodontol. 1997;24(11):796-798. [Crossref]
  • 48. Stojko A, Scheller S, Szwarnowiecka I, Tustanowski J, Ostach H, Obuszko Z. Biological properties and clinical application of propolis. VIII. Experimental observation on the influence of ethanol extract of propolis (EEP) on the regeneration of bone tissue. Arzneimittelforschung. 1978;28(1):35-37.
  • 49. Natarajan K, Singh S, Burke TR, Jr., Grunberger D, Aggarwal B.B. Caffeic acid phenethylester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA. 1996;93(17):9090-9095. [Crossref]
  • 50. Gjertsen AW, Stothz KA, Neiva KG, Pileggi R. Effect of propolis on proliferation and apoptosis of periodontal ligament fibroblasts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(6):843-848. [Crossref]

PROPOLISIN DIŞ HEKIMLIĞINDE KULLANIMI

Yıl 2022, Cilt: 32 Sayı: 2, 181 - 184, 17.04.2022
https://doi.org/10.17567/ataunidfd.933154

Öz

Propolis, arıların farklı bitkisel salgılardan ürettikleri reçinemsi bir maddedir. İçeriğindeki başlıca polifenolleri; fenolik asit ve esterleri, fenolik aldehidler, ketonlar ile birlikte flavonoidler oluşturmaktadır. Propolisdeki fenolik bileşikler hücrelerin oksidatif stresi nötralize etme kapasitesini artırır, antienflamatuar ve antioksidan etkileriyle hücre ölümlerini engellemeye yardımcı olur. Propolisin diş hekimliğinde kullanımı birçok çalışmada yer almıştır. Diş çürüğünü önlemede, kuafaj tedavilerinde pulpa inflamasyonunu önlemede, kanal medikamenti olarak kanal tedavilerinde, avulse dişler için periodontal ligament hücrelerinin canlılığının devamlılığını sağlamak amacıyla saklama ortamı olarak, plak eliminasyonu ve antimikrobiyal ajan olarak propolis çözeltisi ağız gargarası olarak kullanılmaktadır. Bu derlemede propolisin diş hekimliğindeki kullanım alanları tartışılmıştır.
Anahtar Kelimeler: Propolis, flavonoid, antienflamatuar, diş hekimliği

Abstract
Propolis is a sesinous substance that was produced by bees from different herbal secretions. The main polyphenols which propolis contains are made by phenolic acid and its esters, phenolic aldehydes and ketones and flavonoids. The phenolic compounds in propolis increases the capacity of cells to neutralize oxidative stress and help prevent cell death with their antiinflammatory and antioxidant effects. The use of propolis in dentistry has been included in many studies. To prevent tooth caries, preventing pulp inflammation in direct pulp capping, in canal treatments as canal medicament, as a storage medium for avulsion teeth to ensure the continuity of the vitality of periodontal ligament cells and as a plaque elimination and antimicrobial agent, propolis solution is used as mouthwash to prevent tooth caries and pulp inflammation. In this review, the usage areas of propolis in dentistry are discussed.
Keywords: Propolis, flavonoid, antiinflammatory, dentistry

Kaynakça

  • 1. Atik A, Gümüş T. Propolisin gıda endüstrisinde kullanım olanakları. Akademik Gıda. 2017;15(1):60-65. [Crossref]
  • 2. Kasiotis K.M, Anastasiadou P, Papadopoulos A, Machera K. Revisiting Greek propolis: chromatographic analysis and antioxidant activity study. PloS One. 2017;12(1):e0170077. [Crossref]
  • 3. Abd-El-Rhman AMM. Antagonism of Aeromonas hydrophila by propolis and its effect on the performance of Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunol. 2009;27(3):454-459. [Crossref]
  • 4. Ghisalberti E. Propolis: A review. Bee World. 1979;60:59-84. [Crossref]
  • 5. Tezcan C. Propolisin kimyasal fiziksel ve biyolojik özellikleri tıpta kullanım alanları. Yüksek Lisans Tezi, Trakya Üniversitesi Fen Bilimleri Enstitüsü, Tekirdağ, 2000.
  • 6. Schmidt J.O. Bee products, chemical composition and application. In: Mirzahi A. Lensky Y. Bee products, properties, applications and apitherapy. New York; Plenum Press, 1996; 15: 16-21. [Crossref]
  • 7. Bankova V, Decastro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie. 2001;31(1):3-15. [Crossref]
  • 8. Cirasino L, Pisati A, Fasani F. Contact dermatitis from propolis. Contact Dermatitis. 1987;16(2):110-111. [Crossref]
  • 9. Monti M, Berti E, Carminati G, Cusini M. Occupational and cosmetic dermatitis from propolis. Contact Dermatitis. 1983;9(2):163. [Crossref]
  • 10. Libério SA, Pereira AL, Araújo MJ, et al. The potential use of propolis as a cariostatic agent and its actions on mutans group streptococci. J Ethnopharmacol. 2009;125(1):1-9. [Crossref]
  • 11. Ozan F, Sümer Z, Polat ZA, Er K, Ozan U, Deger O. Effect of mouth rinse containing propolis on oral microorganisms and human gingival fibroblast. Eur J Dent. 2007;1(4):195-201. [Crossref]
  • 12. Seidel V, Peyfoon E, Watson DG, Fearnley J. Comparative study of the antibacterial activity of propolis from different geographical and climatic zones. Phytother Res. 2008;22(9):1256-1263. [Crossref]
  • 13. Ferreres FMC, García-Viguera C, Bankova VS, De Castro SL, Dantas AP. Phenolic compounds from Brazilian propolis with pharmacological activities. J Ethnopharmacol. 2001;74(2):105-112. [Crossref]
  • 14. Cook NC, Samman S. Flavonoids-Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem. 1996;7:66-76. [Crossref]
  • 15. Burdock G.A. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 1998;36(4):347-363. [Crossref]
  • 16. Çakıroğlu, T.N. Çeşitli çözücülerde Türk propolisinin çözünürlüğünün incelenmesi. Yüksek Lisans Tezi. Karadeniz Teknik Üniversitesi, Sağlık Bilimleri Enstitüsü, Trabzon 2010.
  • 17. Takeuchi TM, Pereira CG, Braga MEM, Marostica MR, Leal PF, Meireles MAA. Low pressure solvent extraction, microwave assisted, and ultrasound from condimentary plant. In: Extracting Bioactive Compounds for Food Products. CRC Press 2008;137-218. [Crossref]
  • 18. Marcucci MC. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie. 1995;26(2):83-99. [Crossref]
  • 19. Castaldo S, Capasso F. Propolis, an old remedy used in modern medicine. Fitoterapia. 2002;73(Suppl 1):S1-S6. [Crossref]
  • 20. Saarnio AS, Julkenen TR. Phenolic compounds of propolisfrom the boreal coniferous zone. J Apicult Sci. 2012;56(1):13-22. [Crossref]
  • 21. Nirala SK, Bhadauria M. Propolis reverses acetaminophen induced acute hepatorenal alterations: A biochemical and histopathological approach. Arch Pharm Res. 2008;31(4):451-461. [Crossref]
  • 22. Tatefuji T, Izumi N, Ohta T, Arai S, Ikeda M, Kurimoto M. Isolation and identification of compounds from Brazilian propolis which enhance macrophage spreading and mobility. Biol Pharm Bull. 1996;19(7):966-970. [Crossref]
  • 23. Wade C, Friedrich JA, New Canaan CT. Keats; Propolis power plus: the health-promoting properties of the amazing beehive energizer 1996.
  • 24. Koo H, Gomes BP, Rosalen PL, Ambrosano GM, Park YK, Cury JA. In vitro antimicrobial activity of propolis and Arnica Montana against oral pathogens. Arch Oral Biol. 2000;45(2):141-148. [Crossref]
  • 25. Madarova L. Antibacterial properties of propolis. Ceskoslovenska Stomatologie. 1980;80:304-307.
  • 26. Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol. 1999;64(3):235-240. [Crossref]
  • 27. Ferreira FB, Torres SA, Rosa OP, Ferreira CM, Garcia RB, Marcucci MC, Antimicrobial effect of propolis and other substances against selected endodontic pathogens. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(5):709-716. [Crossref]
  • 28. Kuştarcı Y, Sümer P, Kaya A. In vitro antimicrobial activity of propolis samples from three different regions of Anatolia. Curr Res Dent Sci. 2011;21(2):82-87.
  • 29. Ikeno K, Ikeno T, Miyazawa C. Effects of propolis on dental caries in rats. Caries Res. 1991;25(5):347-351. [Crossref]
  • 30. Koru O, Toksoy F, Acikel CH, et al. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. Anaerobe. 2007;13(3):140-145. [Crossref]
  • 31. Duarte S, Rosalen PL, Hayacibara MF, et al. The influence of a novel propolis on mutans streptococci biofilms and caries development in rats. Arch Oral Biol. 2006;51(1):15-22. [Crossref]
  • 32. Cardoso JG, Iorio NLP, Rodrigues LF, et al. Influence of a Brazilian wild green propolis on the enamel mineral loss and Streptococcus mutans’ count in dental biofilm. Arch Oral Biol. 2016;65:77-81. [Crossref]
  • 33. Nam S, Choi Y, Jang S, Shim Y, Han G. Antimicrobial activity of propolis on different oral bacteria. Indian J Sci Tech. 2016;9:1-4. [Crossref]
  • 34. Lin P, Cheng Y, Chu C, Chien K, Lin C, Tu Y. In-office treatment for dentin hypersensitivity: A systematic review and network meta-analysis. J Clin Periodontol. 2013;40(1):53-64. [Crossref]
  • 35. Sales-Peres SH, Carvalho FN, Marsicano JA. Effect of propolis gel on the in vitro reduction of dentin permeability. J Appl Oral Sci. 2011;19(4):318-323. [Crossref]
  • 36. Hussain RA, Dannan A, Al-Ahmad M. Propolis treatment for dental sensitivity after tooth bleaching. Imperial J Interdisciplinary Res. 2017;2:1436-1439.
  • 37. Toker H, Özan F, Özdemir H, Değer O. Dentin hassasiyetinin tedavisinde propolisin etkisi. Gazi Üni Diş Hek Fak Derg. 2008;25(3):1-6.
  • 38. Madhavan S, Nayak M, Shenoy A, Shetty R, Prasad K. Dentinal hypersensitivity: A comparative clinical evaluation of CPP-ACP F, sodium fluoride, propolis, and placebo. J Concerv Dent. 2012;15(4):315-318. [Crossref]
  • 39. Park YK, Alencar SM, Aguiar CL. Botanical origin and chemical composition of Brazilian propolis. J Agric Food Chem. 2002;50(9):2502-2506. [Crossref]
  • 40. Sabir A. The healing actions of propolis on direct pulp capping treatment: A review. J Dentomax Sci. 2016;1:186. [Crossref]
  • 41. Ramos A, Miranda J. Propolis: A review of its antiinflammatory and healing actions. J Ven Animal Toxins Inc Trop Dis. 2007;13(4):697-710. [Crossref]
  • 42. Coutinho A. Honeybee propolis extract in periodontal treatment: A clinical and microbiological study of propolis in periodontal treatment. Indian J Dent Res. 2012;23(2):294. [Crossref]
  • 43. Parolia A, Thomas M.S, Kundabala M, Mohan M. Propolis and its potential uses in oral health. Int J Med Med Sci. 2010;2:210-5.
  • 44. Feres M, Figueiredo LC, Barreto IM, Coelho MH, Araujo MW, Cortelli SC. In vitro antimicrobial activity of plant extracts and propolis in saliva samples of healthy and periodontally-involved subjects. J Int Acad Periodontol. 2005;7(3):90-96.
  • 45. Gebaraa EC, Pustiglioni AN, de Lima LA, Mayer MP. Propolis extract as an adjuvant to periodontal treatment. Oral Health Prev Dent. 2003;1(1):29-35.
  • 46. Koo H, Cury JA, Rosalen PL, Ambrosano GM, Ikegaki M, Park YK. Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation. Caries Res. 2002;36(6):445-448. [Crossref]
  • 47. Murray MC, Worthington HV, Blinkhorn AS. A study to investigate the effect of a propolis-containing mouthrinse on the inhibition of de novo plaque formation. J Clin Periodontol. 1997;24(11):796-798. [Crossref]
  • 48. Stojko A, Scheller S, Szwarnowiecka I, Tustanowski J, Ostach H, Obuszko Z. Biological properties and clinical application of propolis. VIII. Experimental observation on the influence of ethanol extract of propolis (EEP) on the regeneration of bone tissue. Arzneimittelforschung. 1978;28(1):35-37.
  • 49. Natarajan K, Singh S, Burke TR, Jr., Grunberger D, Aggarwal B.B. Caffeic acid phenethylester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA. 1996;93(17):9090-9095. [Crossref]
  • 50. Gjertsen AW, Stothz KA, Neiva KG, Pileggi R. Effect of propolis on proliferation and apoptosis of periodontal ligament fibroblasts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(6):843-848. [Crossref]
Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Diş Hekimliği
Bölüm Derlemeler
Yazarlar

Atanur Sarıoğlu Bu kişi benim

Ersin Ülker Bu kişi benim

Tuğrul Kırtıloğlu Bu kişi benim

Yayımlanma Tarihi 17 Nisan 2022
Gönderilme Tarihi 17 Ağustos 2020
Yayımlandığı Sayı Yıl 2022 Cilt: 32 Sayı: 2

Kaynak Göster

AMA Sarıoğlu A, Ülker E, Kırtıloğlu T. PROPOLISIN DIŞ HEKIMLIĞINDE KULLANIMI. Curr Res Dent Sci. Nisan 2022;32(2):181-184. doi:10.17567/ataunidfd.933154

Current Research in Dental Sciences is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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