Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI

Öz

Objective: Fibrinogen plasma level rises in the event of inflammatory cases. It is known that there is a powerful intercourse between fibrinogen level and plasma viscosity. Albumin plasma level dropes during the inflammatory cases. The aim of this work determine significance of fibrinogen albumin ratio (FAR) as a indicator emphases the burden of atherosclerosis. Method: The study included 83 patients diagnosed with non-ST-segment elevation myocardial infarction (NSTEMI) between January and September 2015. The definition of NSTEMI was made according to “Definition of Third Universal Myocardial Infarction” guidelines published on 2013 by European Society of Cardiology. Burden of atherosclerosis was evaluated by Syntax score (SS) and Gensini Score. Patients were seperated two groups as medium-high SS (n=23) and low SS (n=60). FAR levels were compared. Results: FAR was 80.71 ± 30.3 in low SS group and 120 ± 49.72 in the mid-high SS group respectively (p <0.001). In correlation evaluation, FAR and SS showed a poor positive correlation (r = 0.496, p <0.001). In multivariate logistic regression assesment of elements impacting the SS, prominent variable was found to be FAR [p = 0.01, 95% CI (1005-1042)]. In ROC evaluation FAR values of 85 and over demonstrated 83% sensitivity and 68% specificity in determining the burden of coronary artery disease (CAD). Conclusions: In moderate-high SS group FAR value is considerably higher than those with a low SS group. FAR value may be usefull indicator in clinical practice to determine the burden of coronary artery disease. Keywords: Fibrinogen, albumin, syntax score

Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI

Öz

Objective: Fibrinogen plasma level rises in the event of inflammatory cases. It is known that there is a powerful intercourse between fibrinogen level and plasma viscosity. Albumin plasma level dropes during the inflammatory cases. The aim of this work determine significance of fibrinogen albumin ratio (FAR) as a indicator emphases the burden of atherosclerosis. Method: The study included 83 patients diagnosed with non-ST-segment elevation myocardial infarction (NSTEMI) between January and September 2015. The definition of NSTEMI was made according to “Definition of Third Universal Myocardial Infarction” guidelines published on 2013 by European Society of Cardiology. Burden of atherosclerosis was evaluated by Syntax score (SS) and Gensini Score. Patients were seperated two groups as medium-high SS (n=23) and low SS (n=60). FAR levels were compared. Results: FAR was 80.71 ± 30.3 in low SS group and 120 ± 49.72 in the mid-high SS group respectively (p <0.001). In correlation evaluation, FAR and SS showed a poor positive correlation (r = 0.496, p <0.001). In multivariate logistic regression assesment of elements impacting the SS, prominent variable was found to be FAR [p = 0.01, 95% CI (1005-1042)]. In ROC evaluation FAR values of 85 and over demonstrated 83% sensitivity and 68% specificity in determining the burden of coronary artery disease (CAD). Conclusions: In moderate-high SS group FAR value is considerably higher than those with a low SS group. FAR value may be usefull indicator in clinical practice to determine the burden of coronary artery disease.

Anahtar Kelimeler

• Fibrinogen
• albumin
• syntax score

Kaynakça

1. 1. Ross R. Atherosclerosis an inflammatory disease.N Engl J Med. 1999; 340: 115-26.
2. 2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005; 352: 685-95.
3. 3. Kristensen SD. The platelet-vessel wall interaction in experimental atherosclerosis and ischaemic heart disease with special reference to thrombopoiesis. Dan Med Bull. 1992; 39: 110-27.