The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus

Erdal Kaydu; İbrahim Erbağcı; Seydi Okumuş; Ümit Aksoy

doi:10.5798/diclemedj.0921.2016.01.0640

The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus

Öz

Objective: To evaluate the results of corneal cross-linking with UV-A/riboflavin in patients with progressive keratoconus.
Methods: Forty-seven eyes of 30 patients with progressive keratoconus (16 female, 14 male) were included in the study. Uncorrected and the best corrected distance visual acuities, biomicroscopic findings, intraocular pressure measurements, fundoscopic findings, pachymetric measurements and corneal topography parameters were recorded for each patient.
Results: The mean age of the patients was 18.3±5.34 (range: 8-31) years and the mean follow-up duration was 7±2.4 (range: 3-12) months. Following the procedure, the mean decrease in K1, K2, Kav, spherical and cylindrical values were 0.77 D, 0.85 D, 0.80 D, 0.50 D and 0.74 D, respectively (p<0.05). There were no cases with decrease in visual acuity and significant complication during or after the treatment.
Conclusion: Cross-linking with riboflavin/UV-A in patients with progressive keratoconus is an effective procedure. In addition, the preservation of visual acuity and not seen a significant complication indicate that a safe metod. However, large prospective randomized controlled studies are needed to evaluate the long-term effects of this treatment.
Key words: corneal cross-linking, keratoconus, corneal topography

Anahtar Kelimeler

korneal çapraz bağlama, keratokonus, korneal topografi

Kaynakça

Kennedy RH, Bourne WM, Dyer JA. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol 1986;101:267-273.
Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998;42:297-319.
Krachmer JH, Feder RS, Belin MW. Keratoconus and related non-inflammatory corneal thinning disorders. Surv Ophthalmol 1984;28:293-322.
Wollensak G. Crosslinking treatment of progressive keratoconus:
new hope. Curr Opin Ophthalmol 2006;17:356-360.
Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-ainduced
collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
Spoerl E, Mrochen M, Sliney D, et al. Safety of UVA riboflavin cross-linking of the cornea. Cornea 2007;26:385-389.

Wollensak G, Wilsch M, Spoerl E, Seiler T. Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA. Cornea 2004;23:503-507.
Agrawal VB. Corneal collagen cross-linking with riboflavin and ultraviolet - a light for keratoconus: results in Indian eyes. Indian J Ophthalmol. 2009;57:111-114.
Grewal DS, Brar GS, Jain R, et al. Corneal collagen crosslinking
using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg 2009;35:425-432.
Caporossi A, Baiocchi S, Mazzotta C, et al. Parasurgical
therapy for keratoconus byriboflavin-ultraviolet type A rays
induced cross-linking of corneal collagen: preliminary refractive
results in an Italian study. J Cataract Refract Surg 2006;32:837-845.
Derakhshan A, Shandiz JH, Ahadi M, et al. Short-term outcomes of collagen crosslinking for early keratoconus. J Ophthalmic Vis Res 2011;6:155-159.
Gümüş K, Mirza E, Erkılıç K. ve ark. İlerleyici tip keratokonus
olgularinda riboflavin/UV-A ile çapraz bağlama tedavisinin erken dönem sonuçlari. TOD Derg 2010;40:18-24.
Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 2008;34:796-801.
Coşkunseven E, Jankov MR, Hafezi F. Contralateral eye study of corneal collagen cross-linking with riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg 2009;25:371-376.
Caporossi A, Mazzotta C, Baiocchi S, Caporossi T. Longterm results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 2010;149:585-593.
Mazzotta C, Balestrazzi A, Traversi C. et al. Treatment of progressive keratoconus by riboflavin-UVA-induced crosslinking of corneal collagen.Ultrastructural analysis by Heidelberg Retinal Tomography II invivo confocal microscopy in humans. Cornea 2007;26:390-397.
Kymionis GD, Diakonis VF, Kalyvianaki M. et al. Oneyear follow-up of corneal confocal microscopy after corneal cross-linking in patients with post laser in situ keratosmileusis ectasia and keratoconus. Am J Ophthalmol 2009;147:774-778.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Erdal Kaydu Bu kişi benim

İbrahim Erbağcı Bu kişi benim

Seydi Okumuş Bu kişi benim

Ümit Aksoy Bu kişi benim

Yayımlanma Tarihi

1 Mart 2016

Gönderilme Tarihi

29 Mart 2016

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2016 Cilt: 43 Sayı: 1

DOI

https://doi.org/10.5798/diclemedj.0921.2016.01.0640

IZ

https://izlik.org/JA54EJ48AE

Kaynak Göster

RIS / Bibtex

APA

Kaydu, E., Erbağcı, İ., Okumuş, S., & Aksoy, Ü. (2016). The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus. Dicle Medical Journal, 43(1), 67-72. https://doi.org/10.5798/diclemedj.0921.2016.01.0640

AMA

1.Kaydu E, Erbağcı İ, Okumuş S, Aksoy Ü. The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus. diclemedj. 2016;43(1):67-72. doi:10.5798/diclemedj.0921.2016.01.0640

Chicago

Kaydu, Erdal, İbrahim Erbağcı, Seydi Okumuş, ve Ümit Aksoy. 2016. “The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus”. Dicle Medical Journal 43 (1): 67-72. https://doi.org/10.5798/diclemedj.0921.2016.01.0640.

EndNote

Kaydu E, Erbağcı İ, Okumuş S, Aksoy Ü (01 Mart 2016) The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus. Dicle Medical Journal 43 1 67–72.

IEEE

[1]E. Kaydu, İ. Erbağcı, S. Okumuş, ve Ü. Aksoy, “The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus”, diclemedj, c. 43, sy 1, ss. 67–72, Mar. 2016, doi: 10.5798/diclemedj.0921.2016.01.0640.

ISNAD

Kaydu, Erdal - Erbağcı, İbrahim - Okumuş, Seydi - Aksoy, Ümit. “The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus”. Dicle Medical Journal 43/1 (01 Mart 2016): 67-72. https://doi.org/10.5798/diclemedj.0921.2016.01.0640.

JAMA

1.Kaydu E, Erbağcı İ, Okumuş S, Aksoy Ü. The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus. diclemedj. 2016;43:67–72.

MLA

Kaydu, Erdal, vd. “The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus”. Dicle Medical Journal, c. 43, sy 1, Mart 2016, ss. 67-72, doi:10.5798/diclemedj.0921.2016.01.0640.

Vancouver

1.Erdal Kaydu, İbrahim Erbağcı, Seydi Okumuş, Ümit Aksoy. The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus. diclemedj. 01 Mart 2016;43(1):67-72. doi:10.5798/diclemedj.0921.2016.01.0640