Prevalence of BRAF Mutation in Papillary Thyroid Cancer

Shatha Dmour; Ala’a Al - Maaitah; Tunc Eren; Ozgur Ekinci; Orhan Alimoglu

doi:10.5798/diclemedj.0921.2015.01.0521

Prevalence of BRAF Mutation in Papillary Thyroid Cancer

Öz

Objectives: Papillary thyroid cancer (PTC) is the most common endocrine malignancy and the most common genetic anomaly with PTC is the BRAF V600E mutation. This mutation is linked to many clinical and pathological features and may have a diagnostic and therapeutic role especially in the era of targeted therapy. The aim of this study is to review the prevalence of BRAF V600E mutation in PTC, its distribution according to the histological subtype and geographic area and its association with the age of patients, gender, subtype and recurrence of tumors.

Methods: The Pubmed database was searched to look for articles about BRAF mutation in PTC. Outcomes of interest included prevalence, age, gender, country, subtype and recurrence.

Results: The prevalence of BRAF V600E mutation in PTC was 47%, with noticeably higher prevalence in the eastern countries. The prevalence of BRAF V600E was also higher in the tall and classic subtypes and could be associated with worse prognosis and higher risk of recurrence.

Conclusions: The BRAF mutation, which is more prevalent in the eastern countries, is determined to be an important molecular marker for PTC.

Anahtar Kelimeler

Papillary thyroid cancer,BRAF mutation

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Derleme

Yazarlar

Shatha Dmour Bu kişi benim

Ala’a Al - Maaitah Bu kişi benim

Tunc Eren Bu kişi benim

Ozgur Ekinci Bu kişi benim

Orhan Alimoglu

Yayımlanma Tarihi

25 Aralık 2016

Gönderilme Tarihi

11 Ocak 2017

Kabul Tarihi

29 Kasım 2016

Yayımlandığı Sayı

Yıl 2016 Cilt: 43 Sayı: 4

DOI

https://doi.org/10.5798/diclemedj.0921.2015.01.0521

IZ

https://izlik.org/JA96YP63UD

Kaynak Göster

RIS / Bibtex

APA

Dmour, S., Maaitah, A. A.-, Eren, T., Ekinci, O., & Alimoglu, O. (2016). Prevalence of BRAF Mutation in Papillary Thyroid Cancer. Dicle Medical Journal, 43(4), 569-575. https://doi.org/10.5798/diclemedj.0921.2015.01.0521

AMA

1.Dmour S, Maaitah AA, Eren T, Ekinci O, Alimoglu O. Prevalence of BRAF Mutation in Papillary Thyroid Cancer. diclemedj. 2016;43(4):569-575. doi:10.5798/diclemedj.0921.2015.01.0521

Chicago

Dmour, Shatha, Ala’a Al - Maaitah, Tunc Eren, Ozgur Ekinci, ve Orhan Alimoglu. 2016. “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”. Dicle Medical Journal 43 (4): 569-75. https://doi.org/10.5798/diclemedj.0921.2015.01.0521.

EndNote

Dmour S, Maaitah AA-, Eren T, Ekinci O, Alimoglu O (01 Aralık 2016) Prevalence of BRAF Mutation in Papillary Thyroid Cancer. Dicle Medical Journal 43 4 569–575.

IEEE

[1]S. Dmour, A. A.- Maaitah, T. Eren, O. Ekinci, ve O. Alimoglu, “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”, diclemedj, c. 43, sy 4, ss. 569–575, Ara. 2016, doi: 10.5798/diclemedj.0921.2015.01.0521.

ISNAD

Dmour, Shatha - Maaitah, Ala’a Al - - Eren, Tunc - Ekinci, Ozgur - Alimoglu, Orhan. “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”. Dicle Medical Journal 43/4 (01 Aralık 2016): 569-575. https://doi.org/10.5798/diclemedj.0921.2015.01.0521.

JAMA

1.Dmour S, Maaitah AA-, Eren T, Ekinci O, Alimoglu O. Prevalence of BRAF Mutation in Papillary Thyroid Cancer. diclemedj. 2016;43:569–575.

MLA

Dmour, Shatha, vd. “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”. Dicle Medical Journal, c. 43, sy 4, Aralık 2016, ss. 569-75, doi:10.5798/diclemedj.0921.2015.01.0521.

Vancouver

1.Shatha Dmour, Ala’a Al - Maaitah, Tunc Eren, Ozgur Ekinci, Orhan Alimoglu. Prevalence of BRAF Mutation in Papillary Thyroid Cancer. diclemedj. 01 Aralık 2016;43(4):569-75. doi:10.5798/diclemedj.0921.2015.01.0521