Prognostic Value of Lymph Node and Spleen Activity in [18F]FDG PET-CT in Lung Adenocarcinoma and Squamous Cell Carcinoma
Öz
Objective: We aimed to investigate the prognostic value of primary mass, spleen and lymph node metabolic activity in [18F]FDG PET-CT as well as the prognostic value of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (TLR) in patients with lung adenocarcinoma and squamous cell carcinoma.
Objective: We aimed to investigate the prognostic value of primary mass, spleen and lymph node metabolic activity in [18F]FDG PET-CT as well as the prognostic value of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (TLR) in patients with lung adenocarcinoma and squamous cell carcinoma.
Results: The SUVmax spleen/liver and SUVmax lymph node/liver ratios were significantly higher in the exitus subgroup of squamous cell carcinoma (p=0.025, p=0.043; respectively). The SUVmax lymph node/liver ratio was found to be a predictor for survival in squamous cell carcinoma (p=0.019, OR:1.282). The SUVmax spleen/liver and SUVmax lymph node/liver ratios were similar between subgroups of adenocancer.
Conclusions: The SUV ratios of the spleen were not a predictor for survival in both groups. The SUVmax lymph node/liver ratio was found to be a predictor for survival in squamous cell carcinoma. However, NLR and PLR were not found to be prognostic factors.
Anahtar Kelimeler
Kaynakça
- 1. Vansteenkiste J, Fischer BM, Dooms C, et all. Positron emission tomography in prognostic and therapeutic assessment of lung cancer: systematic review. Lancet Oncol. 2004; 5: 531-40.
- 2. de Geus-Oei LF, van Krieken JH, Aliredjo RP et all. Biological correlates of FDG uptake in non-small cell lung cancer. Lung Cancer. 2007; 55: 79-87.
- 3. chuurbiers OC, Meijer TW, Kaanders JH, et all. Glucose metabolism in NSCLC is histology-specific and diverges the prognostic potential of 18FDG-PET for adenocarcinoma and squamous cell carcinoma.. J Thorac Oncol. 2014; 9: 1485-93.
- 4. Lee HY, Lee HJ, Kim YT, et all. Value of combined interpretation of computed tomography response and positron emission tomography response for prediction of prognosis after neoadjuvant chemotherapy in non- small cell lung cancer. J Thorac Oncol. 2010; 5: 497- 503.
- 5. Nair VS, Krupitskaya Y, Gould MK. Positron emission tomography 18F fluorodeoxyglucose uptake and prognosis in patients with surgically treated, stage I non small cell lung cancer: a systematic review. J Thorac Oncol. 2009;12: 1473-9.
- 6. Lee JW, Na JO, Kang DY, Lee SY, Lee SM. Prognostic Significance of FDG Uptake of Bone Marrow on PET/CT in Patients With Non-Small-Cell Lung Cancer After Curative Surgical Resection. Clin Lung Cancer. 2017; 18: 198-206.
- 7. Prévost S, Boucher L, Larivée P, et all. Bone marrow hypermetabolism on 18F-FDG PET as a survival prognostic factor in non small cell lung cancer. 2006; 4:559-65.
- 8. Blebea JS, Houseni M, Torigian DA, et all. Structural and functional imaging of normal bone marrow and evaluation of its age-related changes. Semin Nucl Med. 2007; 37:185-94.
Ayrıntılar
Birincil Dil
İngilizce
Konular
Sağlık Kurumları Yönetimi
Bölüm
Araştırma Makalesi
Yazarlar
Halil Komek
Bu kişi benim
Türkiye
Zuhat Urakci
Bu kişi benim
Canan Can
Bu kişi benim
Serdar Altindag
Bu kişi benim
Yayımlanma Tarihi
3 Mart 2019
Gönderilme Tarihi
2 Temmuz 2018
Kabul Tarihi
-
Yayımlandığı Sayı
Yıl 2019 Cilt: 46 Sayı: 1