-

Öz

Objective: To investigate the troponin I (cTnI) levels in preeclamptic women, compare with the values of healthy pregnant women and also to evaluate whether the association between troponin I levels with severity of preeclampsia.Methods: This study was performed with 83 preeclamptic pregnant women and 40 pregnant women control group having no medical problems who has admitted to the Obstetrics and Gynecology Clinics of Dicle University Medical Faculty between February 2009 and July 2009. Serum troponin I levels were measured and compared between two groups.Results: There was no correlation between serum cTnI levels with hemoglobin, hematocrit age, BMI, platelet count, systolic blood pressure, diastolic blood pressure, ALT, AST, LDH, urea and creatinine. There was no significant differences between the groups in preeclampsia and healthy pregnant women when compared in terms of Troponin I levels (p = 0.501) Conclusion: Preeclampsia was not associated with troponin I levels in our study. So patients with preeclampsia and elevated troponin levels should have further cardiac investigations and close cardiovascular follow-up

Anahtar Kelimeler

• Troponin I, preeclampsia, pregnancy

Preeklampside serum Troponin I düzeyinin değerlendirilmesi

Öz

Amaç: Preeklamptik gebelerde troponin I (cTnI) düzeylerini araştırmak, sağlıklı gebelerin değerleri ile karşılaştırmak ve ayrıca preeklampsinin şiddeti ile troponin I düzeyleri arasında ilişki olup olmadığını değerlendirmek amaçlanmıştır.

Yöntemler: Bu çalışmada, Şubat 2009 ile Temmuz 2009 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı’na başvuran, ardışık 83 preeklamptik gebe ile medikal problemi olmayan kontrol grubu olarak alınan 40 gebede serum troponin I düzeyleri ölçülmüş ve karşılaştırılmıştır.

Bulgular: Serum cTnI seviyesi ile yaş, VKİ, trombosit sayısı, sistolik kan basıncı, diastolik kan basıncı ALT, AST, LDH, üre, kreatinin, hematokrit hemoglobin değerleri arasında ilişki saptanmamıştır. Preeklampsi ve sağlıklı gebelerdeki Troponin I düzeyleri karşılaştırıldığında gruplar arasında anlamlı farklılık saptanmamıştır (p=0,501)

Sonuç: Preeklampsi ile troponin I seviyeleri arasında ilişki bulunamadı. Yüksek troponin I düzeyi saptanan preeklamptik gebelerde ileri kardiyolojik tetkik yapılmasının gerekli olduğu değerlendirildi.

Anahtar kelimeler: Troponin I, preeklampsi, gebelik

Anahtar Kelimeler

• Troponin I, preeklampsi, gebelik

Kaynakça

1. Hallak M. James DK, Steer PJ, Weiner CP, et al. High Risk
2. Pregnancy Management Options Hypertension in pregnancy .W.B.Saunders, second edition. Philadelphia 2006:772-797.
3. Scott R: Danforth Obstetrics and Gynecology, 9th edition.
4. Hypertensive Disorders of Pregnancy J.B. Lippincott company. Philadelphia 2003:257-271.
5. Durukan T. Kişnişçi HA, Göksin E,et al. Temel Kadın Hastalıkları ve Doğum Bilgisi. Gebelikte hipertansiyon, preeklampsi-eklampsi. Güneş Kitabevi, Ankara 1996:1647-1651.
6. Dekker GA, Sibai BM. Pathogenesis and etiology of preeclampsia. Am J Obstet Gynecol 1998;179:1359.
7. Jonel S, Lockwood CJ, Berkowitz SG, et al. Risk factors for
8. severe preeclampsia. Obstet Gynaecol 1994;83:357–361.

9. Paulson RJ, Boostanfar R, Saadat P, et al. Pregnancy in the
10. sixth decade of life: obstetric outcomes in women of advanced reproductive age. JAMA 2002;288:2320–2323.
11. Roth A, Elkayam U. Acute myocardial infarction associated
12. with pregnancy an update. Ann Intern Med 1996;125:751–762.
13. Adams JE, Bodor GS, Davilla-Roman VG, et al. Cardiac
14. troponin I. A marker with high specifity for cardiac injury.
15. Circulation 1994;89:1447-1448.
16. Ebell MH, Flewelling D, Flynn CA. A systematic review of
17. Troponin T and I for diagnosing acute myocardial infarction. J Fam Practice 2000;49:550-556.
18. Lestin M, Hergert M, Lestin HG, ve ark. Evaluation of the
19. chemiluminescence immunoassays for the measurement of
20. troponin I, myoglobin and CK-MB using the IMMULITE
21. system in comparison to other measuring systems. Clin Lab
22. ;48:211-221.220.
23. Panteghini M, Pagani F, Kiang-Teck JY, ve ark. Comparative study of cardiac Troponin I and T measurements in a routine extra-cardiological clinical setting. J Clin Lab Analy Evaluation 2004;15:210-214.
24. Shivvers SA, Wians FH, Keffer JH, et al. Maternal cardiac
25. troponin I levels during normal labor and delivery. Am J
26. Obstet Gynecol 1999;180:122-127.
27. Yang X, Wang H, Wang Z, et al. Alteration and significance
28. of serum cardiac troponin I and cystatin C in preeclampsia.
29. Clin Chim Acta 2006;374:168-169.
30. Kale A, Ecer S,Kale E. Preeklampside Kardiyak Troponin I, CK-MB ve Myoglobin Değerleri Dicle Tıp Dergisi 2005;32:109-112.
31. Atalay C, Erden G, Turhan T,et al. The effect of magnesium sulfate treatment on serum cardiac troponin I levels in preeclamptic women. Acta Obstet Gynecol Scand 2005;84:617–621.
32. Engin Y, Ustun Y, Kurtay G. Cardiac troponin I levels in
33. umbilical cord blood. Int J Gynaecol Obstet 2002;77:239-241.
34. Becerikli F,Çağlar G, GüngörT, et al. Preeklampsi ve gestasyonel hipertansiyonda kardiyak troponin T ,CK-MB ve
35. myoglobulin değerleri, T Klin Jinekol Obst 2004, 14.
36. Shelton SD, Fouse BL, Holleman CM, et al. Cardiac troponin T levels in umbilical cord blood. Am J Obstet Gynecol 1999;181:1259-1262.
37. Massey D. Commentary: Clinical diagnostic use of cystatin
38. C. J Clin Lab Anal 2004;18:55–60.
39. Babay Z, Al-Wakeel J, Addar M, et al. Serum cystatin C in
40. pregnant values, reliable and superior diagnostic accuracy.
41. Clin Exp Obstet Gynecol 2005;32:175–179.
42. Joyal D, Leya F, Koh M, et al. Troponin I Levels in Patients
43. with Preeclampsia, Am J Med 2007;120:13-14.
44. Sprawka N, Timmins A, Sangi-Haghpeykar H, et al. Coonrod Troponin I levels in severe and mild preeclampsia Am J
45. Obstet Gynecol 2008;199:6,174.