Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi

Gönül Zişan Öncel; Nergiz Huseyinoglu; Hatice Kose Ozlece

doi:10.5798/dicletip.661358

Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi

Öz

Objective: Numerous studies investigating Vitamin D receptor (VDR) polymorphisms in different populations have been present in current literature. For this reason, we designed a study to investigate the role of three known common VDR genetic polymorphisms (Apa-I/rs7975232, Bsm-I/ rs1544410 and Taq-I/rs731236) in Turkish individuals affected by Obstructive sleep apnea syndrome (OSAS). Methods: The study was carried out on a total of 175 consecutive subjects, including 80 OSAS patients and 95 healthy participants. Single Nucleotide Polymorphism (SNP) Detection was performed with the iPLEX® Assay and the MassARRAY® System for detection of Apa-I (rs7975232), Bsm-I (rs1544410), and Taq-I (rs731236) polymorphisms. Results: Fifty-seven C alleles (71.3%) and 59 T alleles (73.8%) were detected in the group of 80 OSAS patients in terms of rs1544410 polymorphism. When the patient and control groups were evaluated statistically at allelic level, it was observed that the T allele increased the risk of disease and this increase was statistically significant (Odds Ratio (OR) = 1.549 [Confidence Interval (CI): 1.012-2.371], (p=0.043). However, there were no significant differences between other VDR polymorphisms (rs7975232 and rs731236) and OSAS clinical data (p=0.6 and p=0.9, respectively). Discussion: As a conclusion, no statistically significant relationship was found between all three VDR polymorphisms and OSAS patients' clinical features. Further studies should be performed by creating a large sampling group. Finally, population studies should be given importance considering the variability of polymorphism according to ethnic origin.

Anahtar Kelimeler

Obstructive sleep apnea syndrome,Apnea-hypopnea index

Kaynakça

1. Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013; 177: 1006-14. 2. Ragia G, Archontogeorgis K, Simmaco M, et al. Genetics of Obstructive Sleep Apnea: Vitamin D Receptor Gene Variation Affects Both Vitamin D Serum Concentration and Disease Susceptibility. OMICS. 2019; 23: 45-53. 3. Archontogeorgis K, Nena E, Papanas N, et al. Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives. Pulm Med. 2014; 2014: 930535. Öncel G.Z., Huseyinoglu N., Ozlece H.K. 780 4. Archontogeorgis K, Nena E, Papanas N, et al. The role of vitamin D in obstructive sleep apnoea syndrome. Breathe (Sheff). 2018; 14: 206-15. 5. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008; 5: 136-43. 6. Redline S, Tishler PV. The genetics of sleep apnea. Sleep Med Rev. 2000; 4: 583-602. 7. Palmer LJ, Buxbaum SG, Larkin E, et al. A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet. 2003; 72: 340-50. 8. Strohl KP, Redline S. Recognition of obstructive sleep apnea. Am J Respir Crit Care Med. 1996; 154 (2 Pt 1): 279-89. 9. Neighbors CLP, Noller MW, Song SA, et al. Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med. 2018; 43: 100-8. 10. Fernandes de Abreu DA, Eyles D, Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology. 2009; 34 Suppl 1: S265-77. 11. Haussler MR, Whitfield GK, Kaneko I, et al. Molecular mechanisms of vitamin D action. Calcif Tissue Int. 2013; 92: 77-98. 12. Uitterlinden AG, Fang Y, Van Meurs JB, et all. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004; 338: 143-56. 13. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991; 14: 540-5. 14. Ruehland WR, Rochford PD, O'Donoghue FJ, et al. The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index. Sleep. 2009; 32: 150-7. 15. Sasieni PD. From genotypes to genes: doubling the sample size. Biometrics. 1997; 53: 1253-61. 16. Alizadeh S, Djafarian K, Alizadeh H, et al. Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis. J Nutrigenet Nutrigenomics. 2017; 10: 9-18. 17. Yu F, Cui LL, Li X, et al. The genetic polymorphisms in vitamin D receptor and the risk of type 2 diabetes mellitus: an updated meta-analysis. Asia Pac J Clin Nutr. 2016; 25: 614-24. 18. Wang L, Ma J, Manson JE, et al. A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr. 2013; 52: 1771-9.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Gönül Zişan Öncel Bu kişi benim
0000-0001-6916-5688
Türkiye

Nergiz Huseyinoglu Bu kişi benim
0000-0002-4245-8381
Türkiye

Hatice Kose Ozlece Bu kişi benim
0000-0001-7806-7019
Türkiye

Yayımlanma Tarihi

15 Aralık 2019

Gönderilme Tarihi

5 Ağustos 2019

Kabul Tarihi

4 Kasım 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 46 Sayı: 4

DOI

https://doi.org/10.5798/dicletip.661358

IZ

https://izlik.org/JA79GR34SW

Kaynak Göster

RIS / Bibtex

APA

Öncel, G. Z., Huseyinoglu, N., & Kose Ozlece, H. (2019). Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. Dicle Medical Journal, 46(4), 771-780. https://doi.org/10.5798/dicletip.661358

AMA

1.Öncel GZ, Huseyinoglu N, Kose Ozlece H. Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. diclemedj. 2019;46(4):771-780. doi:10.5798/dicletip.661358

Chicago

Öncel, Gönül Zişan, Nergiz Huseyinoglu, ve Hatice Kose Ozlece. 2019. “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”. Dicle Medical Journal 46 (4): 771-80. https://doi.org/10.5798/dicletip.661358.

EndNote

Öncel GZ, Huseyinoglu N, Kose Ozlece H (01 Aralık 2019) Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. Dicle Medical Journal 46 4 771–780.

IEEE

[1]G. Z. Öncel, N. Huseyinoglu, ve H. Kose Ozlece, “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”, diclemedj, c. 46, sy 4, ss. 771–780, Ara. 2019, doi: 10.5798/dicletip.661358.

ISNAD

Öncel, Gönül Zişan - Huseyinoglu, Nergiz - Kose Ozlece, Hatice. “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”. Dicle Medical Journal 46/4 (01 Aralık 2019): 771-780. https://doi.org/10.5798/dicletip.661358.

JAMA

1.Öncel GZ, Huseyinoglu N, Kose Ozlece H. Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. diclemedj. 2019;46:771–780.

MLA

Öncel, Gönül Zişan, vd. “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”. Dicle Medical Journal, c. 46, sy 4, Aralık 2019, ss. 771-80, doi:10.5798/dicletip.661358.

Vancouver

1.Gönül Zişan Öncel, Nergiz Huseyinoglu, Hatice Kose Ozlece. Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. diclemedj. 01 Aralık 2019;46(4):771-80. doi:10.5798/dicletip.661358

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