Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study

Reyhan Gündüz; Mete Gurol Ugur; Neslihan Bayramoğlu Tepe; Hüseyin Çağlayan Özcan; Özcan Balat; Sevgi Sari Demir; Seyithan Taysi

doi:10.5798/dicletip.706022

Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study

Öz

Objective: This study was aimed to evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels in patients with first trimester miscarriage. Methods: This prospective cohort study included 35 women, who were diagnosed with miscarriage (patient group) and 35 healthy pregnant women below 14 weeks of gestation (control group), who did not report any complaints. 8-OHdG levels were measured with a competitive ELISA (Enzyme-Linked ImmunoSorbent Assay) high sensitivity kit and MDA levels were also measured in both groups. Results: There wasn’t difference in terms of complete blood count, thyroid-stimulating hormone (TSH), homocysteine values, parity, age, body mass index (BMI) and gestational age between the groups. Serum 8-OHdG and MDA levels were significantly higher in the patient group (p=0.001). A moderate positive significant correlation between the gestational week and MDA values and a weak but significant positive correlation between 8-OHdG values and gestational week were detected in the patient group. Conclusion: 8-OHdG and MDA could play a role in the etiopathogenesis of first-trimester miscarriage. However, this role must be further delineated in large-scaled studies for early diagnosis and management of this condition.

Anahtar Kelimeler

Oxidative Stress,malondialdehyde,8-hydroxy-2-deoxyguanosine,miscarriage

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Reyhan Gündüz ^* Bu kişi benim
Türkiye

Mete Gurol Ugur Bu kişi benim
Türkiye

Neslihan Bayramoğlu Tepe Bu kişi benim
Türkiye

Hüseyin Çağlayan Özcan Bu kişi benim
Türkiye

Özcan Balat Bu kişi benim
Türkiye

Sevgi Sari Demir Bu kişi benim
Türkiye

Seyithan Taysi Bu kişi benim
Andorra

Yayımlanma Tarihi

17 Mart 2020

Gönderilme Tarihi

24 Ekim 2019

Kabul Tarihi

22 Ocak 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 47 Sayı: 1

DOI

https://doi.org/10.5798/dicletip.706022

IZ

https://izlik.org/JA46JU84XK

Kaynak Göster

RIS / Bibtex

APA

Gündüz, R., Ugur, M. G., Tepe, N. B., Özcan, H. Ç., Balat, Ö., Demir, S. S., & Taysi, S. (2020). Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Medical Journal, 47(1), 74-81. https://doi.org/10.5798/dicletip.706022

AMA

1.Gündüz R, Ugur MG, Tepe NB, vd. Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. diclemedj. 2020;47(1):74-81. doi:10.5798/dicletip.706022

Chicago

Gündüz, Reyhan, Mete Gurol Ugur, Neslihan Bayramoğlu Tepe, vd. 2020. “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”. Dicle Medical Journal 47 (1): 74-81. https://doi.org/10.5798/dicletip.706022.

EndNote

Gündüz R, Ugur MG, Tepe NB, Özcan HÇ, Balat Ö, Demir SS, Taysi S (01 Mart 2020) Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Medical Journal 47 1 74–81.

IEEE

[1]R. Gündüz vd., “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”, diclemedj, c. 47, sy 1, ss. 74–81, Mar. 2020, doi: 10.5798/dicletip.706022.

ISNAD

Gündüz, Reyhan - Ugur, Mete Gurol - Tepe, Neslihan Bayramoğlu - Özcan, Hüseyin Çağlayan - Balat, Özcan - Demir, Sevgi Sari - Taysi, Seyithan. “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”. Dicle Medical Journal 47/1 (01 Mart 2020): 74-81. https://doi.org/10.5798/dicletip.706022.

JAMA

1.Gündüz R, Ugur MG, Tepe NB, Özcan HÇ, Balat Ö, Demir SS, Taysi S. Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. diclemedj. 2020;47:74–81.

MLA

Gündüz, Reyhan, vd. “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”. Dicle Medical Journal, c. 47, sy 1, Mart 2020, ss. 74-81, doi:10.5798/dicletip.706022.

Vancouver

1.Reyhan Gündüz, Mete Gurol Ugur, Neslihan Bayramoğlu Tepe, Hüseyin Çağlayan Özcan, Özcan Balat, Sevgi Sari Demir, Seyithan Taysi. Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. diclemedj. 01 Mart 2020;47(1):74-81. doi:10.5798/dicletip.706022

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