The importance of background correction during calculation of the major salivary gland function in salivary gland scintigraphy

Yıl 2015, Cilt: 42 Sayı: 4, 459 - 466, 08.01.2016

Bekir Taşdemir , Zeki Dostbil İlhan Sezgin

Öz

Objective: The aim of this study was to compare the parotid (P) and submandibular (SM) glands uptake and excretion ratios of 99mTc-pertechnetate, which were calculated by using the backgrounds drawn on five different areas.

Methods: Ninety-eight P and 98 SM glands of totally 48 patients were included in the study. 99mTc-pertechnetate salivary gland scintigraphy was performed in all patients. Oral stimulation with lemon juice was made at 15th minute of the imaging. The 99mTc-pertechnetate uptake and excretion ratios of the P and SM glands were calculated separately without using any background, and by using the backgrounds drawn on wide frontal, narrow frontal, temporal, cervical and shoulder regions. These values were statistically compared with each other in pairwise manner.

Results: The radioactivity uptake and excretion ratios of the P and SM glands calculated without using any background correction were statistically different from that calculated by using any background correction. In addition, the radioactivity uptake and excretion ratios of the P and SM glands calculated by using the backgrounds drawn on five different areas were mostly found statistically different from each other (p<0.05).

Conclusion: Background correction is important during the calculation of the uptake and excretion ratios of P and SM glands. This study demonstrates that calculated uptake and excretion ratios of P and SM glands may differ according to the used background area.

Key words: Salivary gland scintigraphy, parotid gland, submandibular gland, salivary gland function, background correction

Anahtar Kelimeler

Tükürük bezi sintigrafisi, parotis bezi, submandibuler bez, tükürük bezi fonksiyonu, geri plan düzeltme

Kaynakça

• Anjos DA, Etchebehere EC, Santos AO, et al. Normal values of [99mTc] pertechnetate uptake and excretion fraction by major salivary glands. Nucl Med Commun 2006;27:395-403.
• Yousem DM, Kraut MA, Chalian AA. Major salivary gland imaging. Radiology 2000;216:19-29.
• Afzelius P, Nielsen MY, Ewertsen C, Bloch KP. Imaging of the major salivary glands. Clin Physiol Funct Imaging 2014 Oct 16. doi: 10.1111/cpf.12199. [Epub ahead of print]
• Cheng SC, Wu VW, Kwong DL, Ying MT. Assessment of post-radiotherapy salivary glands. Br J Radiol.2011;84:393-402.
• Hays MT, Berman M. Pertechnetate distribution in man after
• intravenous infusion: a compartmental model. J Nucl Med
• ;18:898–904.
• de Rossi G, Focacci C. A computer-assisted method for semiquantitative assessment of salivary gland diseases. Eur J
• Nucl Med 1980;5:499–503.
• Klutmann S, Bohuslavizki KH, Kroger S, et al. Quantitative salivary gland scintigraphy. J Nucl Med Technol. 1999;27:20–26.
• Bohuslavizki KH, Brenner H, Klutmann S, et al. Implementation
• and indications for quantitative sialoscintigraphy. aryngorhinootologie
• ;76:614–624.
• Wu CB, Xi H, Zhou Q, Zhang LM. The diagnostic value of technetium 99m pertechnetate salivary gland scintigraphy in patients with certain salivary gland diseases. J Oral Maxillofac Surg 2015;73:443-450.
• Malpani BL, Jaiswar RK, Samuel AM. Noninvasive scintigraphic
• method to quantify unstimulated secretions from individual salivary glands. Auris Nasus Larynx. 1999;26:453-456.
• Loutfi I, Nair MK, Ebrahim AK. Salivary gland scintigraphy:the use of semiquantitative analysis for uptake and clearance. J Nucl Med Technol 2003;31:81-85.
• Anjos DA, Etchebehere EC, Santos AO, et al. Normal values of [99mTc]pertechnetate uptake and excretion fraction by major salivary glands. Nucl Med Commun. 2006;27:395-403.
• Senthilkumar B, Sathasivasubramanian S. The role of salivary
• gland scintigraphy in the evaluation of salivary gland dysfunction in uncontrolled Type II diabetic patients. World J Nucl Med. 2013;12:94-100.
• Fallahi B, Beiki D, Abedi SM, et al. Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? Nucl Med Commun 2013;34:777-786.
• Zou Q, Jiao J, Zou MH, et al. Semi-quantitative evaluation of salivary gland function in Sjögren’s syndrome using salivary gland scintigraphy. Clin Rheumatol 2012;31:1699-1705.
• Shimizu H, Matsushima S, Kinosada Y, et al. Evaluation of parotid gland function using equivalent cross-relaxation rate imaging applied magnetization transfer effect. J Radiat Res 2012;53:138-144.
• Kang JY, Jang SJ, Lee WW, et al. Evaluation of salivary gland dysfunction using salivary gland scintigraphy in Sjögren’s Syndrome patients and in thyroid cancer patients after radioactive iodine therapy. Nucl Med Mol Imaging 2011;45:161-168.
• Güne S, Yilmaz S, Karalezli A, Aktaş A. Quantitative and visual evaluation of salivary and thyroid glands in patients with primary Sjögren’s syndrome using salivary gland scintigraphy:relationship with clinicopathological features of salivary, lacrimal and thyroid glands. Nucl Med Commun 2010;31:666-672.
• Baek CH, Chung MK, Choi JY, et al. Role of salivary function in patients with globus pharyngeus. Head Neck 2010;32:244-252.
• Salaffi F, Carotti M, Iagnocco A, et al. Ultrasonography of salivary glands in primary Sjögren’s syndrome: a comparison with contrast sialography and scintigraphy. Rheumatology (Oxford) 2008;47:1244-1249.
• Tenhunen M, Collan J, Kouri M, et al. Scintigraphy in prediction
• of the salivary gland function after gland-sparing intensity odulated radiation therapy for head and neck cancer. Radiother Oncol 2008;87:260-267.
• Middleton ML, Strober MD. Planar scintigraphic imaging of the gastrointestinal tract in clinical practice. Semin Nucl Med 2012;42:33-40.