Subklinik hipotroidi hasta serumlarında homosistein ve irisin seviyelerinin tanısal öneminin belirlenmesi

Yıl 2019, Cilt: 46 Sayı: 4, 751 - 756, 15.12.2019

Diler Us Altay , Ozlem Ozdemır Tevfik Noyan Sefa Yuksel Burhanettin Sertaç Ayhan

https://doi.org/10.5798/dicletip.661286

Öz

Amaç: Bu çalışmanın amacı, subklinik hipotiroidi (SH) hastalarının serumlarında irisin ve homosistein (Hcy) düzeylerinin tanısal önemini belirlemektir.
Yöntemler: Çalışmada 80 kişi değerlendirildi. Hasta grubuna, SH tanısı konmuş 40 hasta ve kontrol grubuna 40 sağlıklı birey dahil edildi. Kan örnekleri toplandı ve enzim bağlı immünosorbent testi (ELISA) kullanılarak serum irisin ve Hcy düzeyleri belirlendi. Tiroid uyarıcı hormon (TSH), serbest triiyodotironin (fT3), serbest tiroksin (fT4) düzeyleri Cobas e 601 otoanalizörü kullanılarak kemilüminesans yöntemiyle ölçüldü.
Bulgular: SH hastalarında Irisin, Hcy, TSH düzeyleri kontrol grubuna göre anlamlı olarak yüksek bulundu (sırasıyla p = 0.0001, p = 0.0001, p = 0.0001). Ayrıca, İrisin ve Hcy seviyeleri TSH seviyeleri kadar spesifik ve sensitifti. SH için en iyi kesme noktaları, İrisin için > 14.43 ng / mL, Hcy için > 13.53 nmol / ml ve TSH için > 4.11 uUI / mL idi.
Sonuç: Irisin, Hcy SH için tanısal bir biyobelirteç olarak kullanılabilir.

Anahtar Kelimeler

irisin, homosistein, subklinik hipotiroidi

Kaynakça

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