Siringaldehit Bazlı Yeni 2,4,6-Triarilpiridin Türevlerinin Antioksidan Aktiviteleri ve Teorik Profili

Yıl 2024, Cilt: 12 Sayı: 2, 981 - 999, 29.04.2024

Esra Nur Albayrak , Samed Şimşek , Ahmad Badreddin Musatat , Zeynep Akşit , Hüseyin Akşit , Alparslan Atahan

https://doi.org/10.29130/dubited.1320385

Öz

Siringaldehitten türetilen sekiz adet yeni 2,4,6-triarilpiridin tasarlandı ve tek basamaklı multi-komponent yöntemle sentezlendi. Bu bileşiklerin antioksidan aktiviteleri bilinen referans bileşiklerle kıyaslanarak değerlendirildi. Daha sonra, B3LYP teorisi ve SVP, TVZP temel setleri kullanılarak, sentezlenen bileşikler için kapsamlı bir teorik kuantum hesaplama yaklaşımı oluşturuldu ve radikal yakalama potansiyelini tanımlayan Fukui indeksleri adlı elektronik yapı tanımlayıcı parametreler belirlendi. Son olarak, teorik ve deneysel sonuçlar karşılaştırılarak yapı-etkinlik ilişkisi ortaya konuldu. Sonuç olarak, elde edilen bileşiklerin antioksidan aktivite potansiyeli teorik bir yaklaşımla da desteklendi.

Anahtar Kelimeler

Triarilpiridin, Siringaldehit, Antioksidan, DFT, Fukui indexi

Kaynakça

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