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Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens

Yıl 2024, Cilt: 12 Sayı: 3, 1461 - 1478, 31.07.2024

Gökçe Gürün , Funda Karbancıoğlu Güler

https://doi.org/10.29130/dubited.1365178

Öz

Changes in agricultural practices, individual diversity, the considerable size of the global food trade, immigrant and tourist circulation, with microorganism transformations have led to the formation of microorganisms that are resistant to chemicals and implementations used, especially antibiotics. Antimicrobial photodynamic therapy (aPDT) is an approach based on the interaction of a natural/synthetic photosensitizer, a suitable light source, and molecular oxygen, and the cytotoxic effect of reactive oxygen species resulting from this interaction on the target microorganism. The benefits of this method, which has found its place in medical terms by treating oral biofilms, superficial lesions, and chronic sinusitis, are limited by problems of low cell/tissue penetration, poor selectivity, non-thermal effect, and off-target damage. Despite similar practical problems in food science, developing technology is expected to encourage new studies on pathogen inactivation in food matrices, reducing the microbial load to safe levels, extending shelf life, and preventing quality loss.

Anahtar Kelimeler

Photodynamic Therapy Photosensitizers Free Radicals Foodborne Pathogens

Kaynakça

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Antimikrobiyal Fotodinamik Terapi: Gıda Kaynaklı Patojenler için Yeni Konsept

Yıl 2024, Cilt: 12 Sayı: 3, 1461 - 1478, 31.07.2024

Gökçe Gürün , Funda Karbancıoğlu Güler

https://doi.org/10.29130/dubited.1365178

Öz

Tarımsal uygulamalardaki değişiklikler, bireysel çeşitlilik, küresel gıda ticaretinin hatırı sayılır büyüklüğü, göçmen ve turist dolaşımı, mikroorganizma dönüşümleri ile başta antibiyotikler olmak üzere kimyasallara ve kullanılan uygulamalara karşı dirençli mikroorganizmaların oluşmasına yol açmıştır. Antimikrobiyal fotodinamik tedavi (aPDT), doğal/sentetik bir ışığa duyarlılaştırıcı, uygun bir ışık kaynağı ve moleküler oksijenin etkileşimi ile bu etkileşim sonucu ortaya çıkan reaktif oksijen türlerinin hedef mikroorganizma üzerinde sitotoksik etkisine dayanan bir yaklaşımdır. Oral biyofilmleri, yüzeysel lezyonları ve kronik sinüziti tedavi ederek tıbbi anlamda kendine yer bulan bu yöntemin faydaları, düşük hücre/doku penetrasyonu, zayıf seçicilik, termal olmayan etki ve hedef dışı hasar sorunları nedeniyle sınırlıdır. Gıda bilimindeki benzer uygulamaya yönelik sorunlara rağmen gelişen teknolojinin, gıda matrislerinde patojen inaktivasyonu, mikrobiyal yükün güvenli seviyelere indirilmesi, raf ömrünün uzatılması ve kalite kaybının önlenmesi konularında yeni çalışmaları teşvik etmesi beklenmektedir.

Anahtar Kelimeler

Fotodinamik tedavi Işığa duyarlılaştırıcılar Serbest radikaller Gıda patojenleri

Kaynakça

  • [1] M. Q. Mesquita, Cristina Barrocas Dias, Maria, A. Almeida, and Maria, “Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy,” Molecules, vol. 23, no. 10, pp. 2424–2424, Sep. 2018, doi: https://doi.org/10.3390/molecules23102424.
  • [2] T. Dubey and S. Chinnathambi, “Photodynamic sensitizers modulate cytoskeleton structural dynamics in neuronal cells,” Cytoskeleton, vol. 78, no. 6, Mar. 2021, doi: https://doi.org/10.1002/cm.21655.
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  • [4] I. R. Calori, W. Caetano, A. C. Tedesco, and N. Hioka, “Self-aggregation of verteporfin in glioblastoma multiforme cells: a static and time-resolved fluorescence study,” Dyes and Pigments, vol. 182, pp. 108598, Nov. 2020, doi: https://doi.org/10.1016/j.dyepig.2020.108598.
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  • [6] E. Polat and K. Kang, “Natural Photosensitizers in Antimicrobial Photodynamic Therapy,” Biomedicines, vol. 9, no. 6, pp. 584, May 2021, doi: https://doi.org/10.3390/biomedicines9060584.
  • [7] I. J. Macdonald and T. J. Dougherty, “Basic principles of photodynamic therapy,” Journal of Porphyrins and Phthalocyanines (JPP), vol. 05, no. 02, pp. 105–129, Feb. 2001, doi: https://doi.org/10.1002/jpp.328.
  • [8] L. do Prado-Silva, G. T. P. Brancini, G. Ú. L. Braga, X. Liao, T. Ding, and A. S. Sant’Ana, “Antimicrobial photodynamic treatment (aPDT) as an innovative technology to control spoilage and pathogenic microorganisms in agri-food products: An updated review,” Food Control, vol. 132, pp. 108527, Feb. 2022, doi: https://doi.org/10.1016/j.foodcont.2021.108527.
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  • [43] Y. Gao et al., “Curcumin-mediated photodynamic inactivation (PDI) against DH5α contaminated in oysters and cellular toxicological evaluation of PDI-treated oysters,” Photodiagnosis and Photodynamic Therapy, vol. 26, pp. 244–251, Jun. 2019, doi: https://doi.org/10.1016/j.pdpdt.2019.04.002.
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Toplam 65 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Ziraat Mühendisliği (Diğer)
Bölüm Makaleler
Yazarlar

Gökçe Gürün 0000-0003-4737-597X

Funda Karbancıoğlu Güler 0000-0001-6576-0084

Yayımlanma Tarihi 31 Temmuz 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 12 Sayı: 3

Kaynak Göster

APA Gürün, G., & Karbancıoğlu Güler, F. (2024). Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi, 12(3), 1461-1478. https://doi.org/10.29130/dubited.1365178
AMA Gürün G, Karbancıoğlu Güler F. Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens. DÜBİTED. Temmuz 2024;12(3):1461-1478. doi:10.29130/dubited.1365178
Chicago Gürün, Gökçe, ve Funda Karbancıoğlu Güler. “Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens”. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi 12, sy. 3 (Temmuz 2024): 1461-78. https://doi.org/10.29130/dubited.1365178.
EndNote Gürün G, Karbancıoğlu Güler F (01 Temmuz 2024) Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens. Düzce Üniversitesi Bilim ve Teknoloji Dergisi 12 3 1461–1478.
IEEE G. Gürün ve F. Karbancıoğlu Güler, “Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens”, DÜBİTED, c. 12, sy. 3, ss. 1461–1478, 2024, doi: 10.29130/dubited.1365178.
ISNAD Gürün, Gökçe - Karbancıoğlu Güler, Funda. “Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens”. Düzce Üniversitesi Bilim ve Teknoloji Dergisi 12/3 (Temmuz 2024), 1461-1478. https://doi.org/10.29130/dubited.1365178.
JAMA Gürün G, Karbancıoğlu Güler F. Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens. DÜBİTED. 2024;12:1461–1478.
MLA Gürün, Gökçe ve Funda Karbancıoğlu Güler. “Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens”. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi, c. 12, sy. 3, 2024, ss. 1461-78, doi:10.29130/dubited.1365178.
Vancouver Gürün G, Karbancıoğlu Güler F. Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens. DÜBİTED. 2024;12(3):1461-78.
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