Aromatik Schiff Bazları ve Co(II), Ni(II) ve Cu(II) Komplekslerinin Sentezi: Antimikrobiyal Aktivitelerinin İncelenmesi

Yıl 2022, , 1049 - 1070, 30.09.2022

Serhan Uruş

https://doi.org/10.31202/ecjse.1099521

Öz

N,N-dietil-p-fenilendiamin ile salisilaldehit ve 2,4-dihidroksibenzaldehit ayrı ayrı reaksiyona sokulup, iki farklı türde Schiff bazı ligantları sentezlenmiştir. Elde edilen ligandların, Co(II), Cu(II) ve Ni(II) kompleksleri sentezlenmiş ve sentezlenen ligand ve metal komplekslerinin yapıları, FT-IR, UV.-Vis., ICP-OES, TG/DTA/DTG, 1H ve 13C NMR ve elemental analiz (C, H, N ve metal içeriği) teknikleri kullanılarak karakterize edilmiştir. Çalışmada elde edilen ligandların ve metal komplekslerin gram pozitif; Staphylococcus aureus Rosenbach ATCC-6538, Bacillus cereus ATCC 7064, gram negatif; Escherichia coli ATCC-8739, Salmonella typhimurium ve Candida albicans ATCC-90028 maya suşuna karşı biyolojik aktiviteleri incelenmiştir. L1 ligand ve komplekslerinin mikroorganizmalara karşı 8,15-12,99 mm, L2 ve komplekslerinin mikroorganizmalara karşı 7,66-13,88 mm çapında inhibisyon zonları gösterdiği belirlenmiştir. Elde edilen bu kompleks yapıların gram negatif ve gram pozitif suşlara karşı olumlu etkisi bulunduğundan hayatımızda yoğun olarak kullanılan antibiyotiklere alternatif olması mümkündür.

Anahtar Kelimeler

Metal kompleksi, Antimikrobiyal Aktivite, Schiff Bazı

Destekleyen Kurum

Kahramanmaraş Sütçü İmam Üniversitesi

Proje Numarası

2021/2-7 YLS, 2019/2-17 YLS

Synthesis of Aromatic Schiff Bases and Co(II), Ni(II) and Cu(II) Complexes: Investigation of Antımicrobial Activities

Öz

Two types of Schiff base ligands were synthesized with the reaction of N,N-diethyl-p-phenylenediamine and salicylaldehyde , 2,4-dihydroxybenzaldehyde separately. Co(II), Cu(II), Ni(II) complexes of the obtained ligants were synthesized and characterized using FT-IR, UV.-Vis., ICP-OES, TG/DTA/DTG, 1H and 13C NMR) and elemental analyses (C, H, N and metal contents analyses). The ligands and metal complexes obtained in the study were gram positive; Staphylococcus aureus Rosenbach ATCC-6538, Bacillus cereus ATCC 7064, gram negative; Escherichia coli ATCC-8739, Salmonella typhimurium and Candida albicans ATCC-90028 yeast strain biological activities against were investigated. It was determined that the L1 ligand and its complexes showed 8.15-12.99 mm diameter inhibition zones against microorganisms, and the L2 and complexes showed 7.66-13.88 mm diameter inhibition zones against microorganisms. Since these complex structures have positive effects against gram-negative and gram-positive strains, it is possible to be an alternative to antibiotics that are used extensively in our lives.

Anahtar Kelimeler

Schiff Base, Metal Complex, Antimicrobial

Proje Numarası

2021/2-7 YLS, 2019/2-17 YLS

Kaynakça

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