The Effects of Silicon Addition to Bioceramic Composition on the Osteoconductive and Osteoinductive Properties

Öz

Bone replacing Ca–phosphate based materials with strong bioactive and osteoconductive properties are being used in many medical and dental applications as coating materials on implant surfaces and as scaffold for the regeneration of bone and dentin. It is possible to produce materials with enhanced biological or physico–chemical properties by doping different suitable ions into hydroxyapatite (HA) structure. Silicon (Si) is the most found element in Earth crust and has many effective properties in living bodies. The main aim of the present study is to supply the current knowledge about apatite materials which contain Si ions. After defining bone, the factors affecting new bone formation, osteoconductivity and osteoinductivity properties, the effect of Si doping into HA structure on osteoconductivite and osteoinductivite features will be mentioned.

Anahtar Kelimeler

• Articifial bone,biomaterial,osteoconductivity,osteoinductivity,silicon,doping,effect

Biyo–Seramik Bileşimine Silisyum Katkısının Osteokondüktif ve Osteoindüktif Özelliklere Etkisi

Öz

Güçlü biyo–aktif ve osteokondüktif özelliklere sahip, kalsiyum fosfat esaslı kemik ikame malzemeleri birçok tıp ve diş uygulamasında implant yüzeyinde çimento veya kaplama malzemesi, kemik ve dentinin yeniden oluşumu (rejenerasyonu) için de iskele olarak kullanılırlar. Kısmi iyon ikamesi için hidroksiapatit (HA) kapasitesinden yararlanılarak HA yapısına farklı iyonlar dâhil edilip gelişmiş biyolojik veya fiziko–kimyasal özellikli malzemeler üretilebilir. Yeryüzünde en fazla bulunan element olan silisyum (Si), canlı vücudunda da pek çok etkin özelliğe sahiptir. Bu çalışmanın amacı Si iyonları ile ikame edilmiş apatit malzemeleri hakkındaki güncel bilgileri sunmaktadır. Kemik, yeni kemik oluşumunu etkileyen parametreler, osteokondüktivite ve osteoindüktivite özellikleri tanımlandıktan sonra HA yapısında kısmi Si iyonu katkısının osteokondüktif ve osteoindüktif özellikleri nasıl etkilediğine dair güncel bilgiler verilmiştir.

Anahtar Kelimeler

• Yapay kemik,biyo-malzeme,osteokondüktivite,osteoindüktivite,silisyum,katkı,etki

Kaynakça

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