Radyasyonun Lamotrijin ve Flurbiprofen Üzerine Etkisinin EPR Çalışması

Öz

Bu çalışmada gama radyasyonun Lamotrijin ve Flurbiprofen’de oluşturduğu hasarları belirlemek için Elektron Paramanyetik Rezonans Spektroskopisi kullanıldı. Örneklerde oluşan serbest radikallerin bazı alkil ve amin türü radikaller olabileceği şeklinde yorumlandı. Radikallerin g değerleri ve aşırı ince yapı sabitleri belirlendi. Örneklerin spektrum simülasyonları bilgisayar kullanılarak gerçekleştirildi. Örneklerde oluşan serbest radikallerin oda sıcaklığında iki aydan daha fazla kararlı olduğu ortaya çıktı

Anahtar Kelimeler

• EPR
• ilaç
• serbest radikal
• gama radyasyonu

Radiation Effects on Lamotrigine and Flourbiprofen: an EPR study

Öz

Electron paramagnetic resonance (EPR) spectroscopy was used to determine the gamma radiation damages in Lamotrigine and Flurbiprofen.The free radicals produced in the samples were interpreted in terms of some type of alkyl and amine radical fragments. The g values and hyperfine structure constants of the radicals were determined and the spectra were computer simulated. In this study, the free radicals were appeared to be stable at room temperature for more than two months.

Anahtar Kelimeler

• EPR
• drugs
• free radicals
• gamma irradiation

Kaynakça

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